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The multitalented M...
The multitalented Mediator complex
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- Carlsten, Jonas O P (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Zhu, Xuefeng (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Gustafsson, Claes M, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Trends in Biochemical Sciences. - : Elsevier BV. - 0968-0004. ; 38:11, s. 531-537
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Abstract
Subject headings
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- The Mediator complex is needed for regulated transcription of RNA polymerase II (Pol II)-dependent genes. Initially, Mediator was only seen as a protein bridge that conveyed regulatory information from enhancers to the promoter. Later studies have added many other functions to the Mediator repertoire. Indeed, recent findings show that Mediator influences nearly all stages of transcription and coordinates these events with concomitant changes in chromatin organization. We review the multitude of activities associated with Mediator and discuss how this complex coordinates transcription with other cellular events. We also discuss the inherent difficulties associated with in vivo characterization of a coactivator complex that can indirectly affect diverse cellular processes via changes in gene transcription.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Mediator
- cohesin
- chromatin looping
- RNA polymerase II
- CDK8
- non-coding RNA
- RNA-POLYMERASE-II
- FISSION YEAST CENTROMERES
- TRANSCRIPTIONAL
- REGULATION
- IN-VIVO
- CHROMATIN ARCHITECTURE
- COACTIVATOR COMPLEX
- MODULE
- ASSOCIATION
- INTERACTION DOMAIN
- GENE-EXPRESSION
- NONCODING RNAS
Publication and Content Type
- ref (subject category)
- art (subject category)
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