Sökning: onr:"swepub:oai:gup.ub.gu.se/190418" > A genome-wide searc...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05377naa a2200685 4500 | |
001 | oai:gup.ub.gu.se/190418 | |
003 | SwePub | |
008 | 240910s1999 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/1904182 URI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Samuelsson, Lena,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics4 aut0 (Swepub:gu)xsamle |
245 | 1 0 | a A genome-wide search for genes predisposing to familial psoriasis by using a stratification approach |
264 | 1 | c 1999 |
520 | a We have performed a genome scan, using markers spaced by 10 cM, in the search for psoriasis-susceptibility loci. The family material of 134 affected sibling pairs was ascertained on the basis of a population genetic study in which 65% of the probands had two healthy parents. Genotyping results were analyzed for non-random excessive allele-sharing between sib pairs by using GENEHUNTER ver 1.1. A stratification approach was applied to increase the homogeneity of the material by means of an operational definition of joint complaints among affected individuals. Significant linkage to the human leukocyte antigen region on chromosome 6p in a cohort including 42 families without joint complaints (nonparametric linkage score of 2.83, P=0.002) strongly supported the validity of this operational definition as it replicated results from an earlier linkage report with similar stratification criteria. New candidate regions on chromosomes 3 and 15 were identified. The highest non-parametric linkage values in this study, 2.96 (P=0.0017) and 2.89 (P=0.0020), were reached on chromosome 15 in a subgroup with joint complaints and on chromosome 3 in a subgroup without joint complaints. In addition, confirmation of previously reported loci was established on chromosomes 4q, 6p, and 17q. This study indicates that distinct disease loci might be involved in psoriasis etiology for various phenotypes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskap0 (SwePub)3052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciences0 (SwePub)3052 hsv//eng |
653 | a Arthritis | |
653 | a Psoriatic/*genetics | |
653 | a Chromosomes | |
653 | a Human | |
653 | a Pair 15 | |
653 | a Chromosomes | |
653 | a Human | |
653 | a Pair 17 | |
653 | a Chromosomes | |
653 | a Human | |
653 | a Pair 3 | |
653 | a Chromosomes | |
653 | a Human | |
653 | a Pair 4 | |
653 | a Chromosomes | |
653 | a Human | |
653 | a Pair 6 | |
653 | a Female | |
653 | a *Genetic Predisposition to Disease | |
653 | a *Genome | |
653 | a Human | |
653 | a Genotype | |
653 | a HLA Antigens/genetics | |
653 | a Humans | |
653 | a *Linkage (Genetics) | |
653 | a Male | |
653 | a Questionnaires | |
653 | a Statistics | |
653 | a Nonparametric | |
700 | 1 | a Enlund, Fredrik,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics4 aut0 (Swepub:gu)xenluf |
700 | 1 | a Torinsson Naluai, Åsa,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa,Institute for the Health of Women and Children4 aut0 (Swepub:gu)xnalas |
700 | 1 | a Yhr, Maria,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa,Institute for the Health of Women and Children4 aut0 (Swepub:gu)xyhrma |
700 | 1 | a Inerot, Annica,d 1949u Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology4 aut0 (Swepub:gu)xinean |
700 | 1 | a Enerbäck, Charlotta,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology4 aut0 (Swepub:gu)xenech |
700 | 1 | a Wahlström, Jan,d 1939u Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics4 aut0 (Swepub:gu)xwahja |
700 | 1 | a Swanbeck, Gunnar,d 1934u Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology4 aut |
700 | 1 | a Martinsson, Tommy,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics4 aut0 (Swepub:gu)xmarto |
710 | 2 | a Göteborgs universitetb Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik4 org |
773 | 0 | t Hum Genetg 105:6, s. 523-9q 105:6<523-9x 0340-6717x 0340-6717 |
856 | 4 8 | u https://gup.ub.gu.se/publication/190418 |
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