Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry.

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Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry.

Lehmann, S (author): Karolinska Institutet,Karolinska University Hospital

Ravn, A (author): Karolinska Institutet,Karolinska University Hospital

Carlsson, L (author): Karolinska University Hospital

Antunovic, Petar (author): Linköpings universitet,Hälsouniversitetet,Kirurgi

Deneberg, S (author): Karolinska Institutet,Karolinska University Hospital,Sahlgrens University Hospital

Möllgård, L (author): Karolinska Institutet,Karolinska University Hospital

Derolf, A Rangert (author): Karolinska University Hospital

Stockelberg, Dick, 1950 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine

Tidefelt, Ulf, 1951- (author): Örebro universitet,Institutionen för hälsovetenskap och medicin,Orebro University Hospital

Wahlin, Anders (author): Umeå universitet,Institutionen för strålningsvetenskaper,Umea University

Wennström, Lovisa (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,Sahlgrens University Hospital

Höglund, M (author): Uppsala universitet,Medicin,Hematologi,Acad Hospital, Uppsala

Juliusson, Gunnar (author): Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skane University Hospital

Ravn, S (author)

Högberg, M (author)

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(creator_code:org_t)

2011-04-19
2011
English.
In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 25:7, s. 1128-34

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Journal article (peer-reviewed)

Abstract Subject headings

Our knowledge about acute promyelocytic leukemia (APL) patients is mainly based on data from clinical trials, whereas population-based information is scarce. We studied APL patients diagnosed between 1997 and 2006 in the population-based Swedish Adult Acute Leukemia Registry. Of a total of 3897 acute leukemia cases, 3205 (82%) had non-APL acute myeloid leukemia (AML) and 105 (2.7%) had APL. The incidence of APL was 0.145 per 100,000 inhabitants per year. The median age at the time of diagnosis was 54 years; 62% were female and 38% male. Among younger APL patients, female sex predominated (89% of patients <40 years). Of the 105 APL patients, 30 (29%) died within 30 days (that is, early death (ED)) (median 4 days) and 28 (26%) within 14 days from diagnosis. In all, 41% of the EDs were due to hemorrhage; 35% of ED patients never received all-trans-retinoic acid treatment. ED rates increased with age but more clearly with poor performance status. ED was also associated with high white blood cells, lactate dehydrogenase, creatinine, C-reactive protein and low platelet count. Of non-ED patients, 97% achieved complete remission of which 16% subsequently relapsed. In total, 62% are still alive at 6.4 years median follow-up. We conclude that ED rates remain very high in an unselected APL population.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

Adolescent
Adult
Age Distribution
Aged
Aged
80 and over
Antineoplastic Combined Chemotherapy Protocols
therapeutic use
Cause of Death
Female
Hemorrhage
etiology
mortality
Humans
Incidence
Kaplan-Meier Estimate
Leukemia
Promyelocytic
Acute
blood
complications
diagnosis
drug therapy
mortality
Male
Middle Aged
Mortality
trends
Prognosis
Registries
Risk Factors
Sex Distribution
Sweden
epidemiology
Time Factors
Young Adult
acute promyelocytic leukemia; incidence; early mortality; hemorrhagic death; population based
acute promyelocytic leukemia
incidence
early mortality
hemorrhagic
death
population based
MEDICINE

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art (subject category)

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By the author/editor: Lehmann, S; Ravn, A; Carlsson, L; Antunovic, Petar; Deneberg, S; Möllgård, L; show more...; Derolf, A Ranger ...; Stockelberg, Dic ...; Tidefelt, Ulf, 1 ...; Wahlin, Anders; Wennström, Lovis ...; Höglund, M; Juliusson, Gunna ...; Ravn, S; Högberg, M; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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