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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05554naa a2200913 4500 | |
| 001 | oai:gup.ub.gu.se/227810 | |
| 003 | SwePub | |
| 008 | 240528s2015 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2278102 URI |
| 024 | 7 | a https://doi.org/10.1002/eji.2014450582 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Akeus, Paulinau Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xfaspa |
| 245 | 1 0 | a Treg-cell depletion promotes chemokine production and accumulation of CXCR3(+) conventional T cells in intestinal tumors. |
| 264 | c 2015-04-14 | |
| 264 | 1 | b Wiley,c 2015 |
| 520 | a Colorectal cancer (CRC) is one of the most prevalent tumor types worldwide and tumor-infiltrating T cells are crucial for anti-tumor immunity. We previously demonstrated that Treg cells from CRC patients inhibit transendothelial migration of conventional T cells. However, it remains unclear if local Treg cells affect lymphocyte migration into colonic tumors. By breeding APC(Min/+) mice with depletion of regulatory T cells mice, expressing the diphtheria toxin receptor under the control of the FoxP3 promoter, we were able to selectively deplete Treg cells in tumor-bearing mice, and investigate the impact of these cells on the infiltration of conventional T cells into intestinal tumors. Short-term Treg-cell depletion led to a substantial increase in the frequencies of T cells in the tumors, attributed by both increased infiltration and proliferation of T cells in the Treg-cell-depleted tumors. We also demonstrate a selective increase of the chemokines CXCL9 and CXCL10 in Treg-cell-depleted tumors, which were accompanied by accumulation of CXCR3(+) T cells, and increased IFN-γ mRNA expression. In conclusion, Treg-cell depletion increases the accumulation of conventional T cells in intestinal tumors, and targeting Treg cells could be a possible anti-tumor immunotherapy, which not only affects T-cell effector functions, but also their recruitment to tumors. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
| 653 | a Adenomatous Polyposis Coli Protein | |
| 653 | a metabolism | |
| 653 | a Animals | |
| 653 | a Cell Adhesion Molecules | |
| 653 | a metabolism | |
| 653 | a Chemokines | |
| 653 | a biosynthesis | |
| 653 | a Chemotaxis | |
| 653 | a immunology | |
| 653 | a Colorectal Neoplasms | |
| 653 | a immunology | |
| 653 | a metabolism | |
| 653 | a Cytokines | |
| 653 | a biosynthesis | |
| 653 | a Disease Models | |
| 653 | a Animal | |
| 653 | a Female | |
| 653 | a Intestinal Mucosa | |
| 653 | a immunology | |
| 653 | a metabolism | |
| 653 | a Lymphocyte Activation | |
| 653 | a immunology | |
| 653 | a Lymphocyte Depletion | |
| 653 | a Lymphocytes | |
| 653 | a Tumor-Infiltrating | |
| 653 | a immunology | |
| 653 | a metabolism | |
| 653 | a Mice | |
| 653 | a Phenotype | |
| 653 | a Receptors | |
| 653 | a CXCR3 | |
| 653 | a metabolism | |
| 653 | a Receptors | |
| 653 | a Chemokine | |
| 653 | a metabolism | |
| 653 | a T-Lymphocyte Subsets | |
| 653 | a immunology | |
| 653 | a metabolism | |
| 653 | a T-Lymphocytes | |
| 653 | a Regulatory | |
| 653 | a immunology | |
| 653 | a Th1 Cells | |
| 653 | a immunology | |
| 653 | a metabolism | |
| 653 | a Vascular Cell Adhesion Molecule-1 | |
| 653 | a metabolism | |
| 700 | 1 | a Langenes, Veronicau Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut |
| 700 | 1 | a Kristensen, Jonasu Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut |
| 700 | 1 | a von Mentzer, Astrid,d 1983u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xvoast |
| 700 | 1 | a Sparwasser, Tim4 aut |
| 700 | 1 | a Raghavan, Sukanya,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xragsu |
| 700 | 1 | a Quiding-Järbrink, Marianne,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xquima |
| 710 | 2 | a Göteborgs universitetb Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi4 org |
| 773 | 0 | t European journal of immunologyd : Wileyg 45:6, s. 1654-66q 45:6<1654-66x 1521-4141x 0014-2980 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.201445058 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/227810 |
| 856 | 4 8 | u https://doi.org/10.1002/eji.201445058 |
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