Sökning: onr:"swepub:oai:gup.ub.gu.se/249811" > FBXO31 protects aga...
Fältnamn | Indikatorer | Metadata |
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000 | 03239naa a2200385 4500 | |
001 | oai:gup.ub.gu.se/249811 | |
003 | SwePub | |
008 | 240910s2017 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2498112 URI |
024 | 7 | a https://doi.org/10.1038/onc.2016.2682 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Jeffery, J M4 aut |
245 | 1 0 | a FBXO31 protects against genomic instability by capping FOXM1 levels at the G2/M transition. |
264 | c 2016-08-29 | |
264 | 1 | b Springer Science and Business Media LLC,c 2017 |
520 | a F-box proteins in conjunction with Skp1, Cul1 and Rbx1 generate SCF complexes that are responsible for the ubiquitination of proteins, leading to their activation or degradation. Here we show that the F-box protein FBXO31 is required for normal mitotic progression and genome stability due to its role in regulating FOXM1 levels during the G2/M transition. FBXO31-depleted cells undergo a transient delay in mitosis due to an activated spindle checkpoint concomitant with an increase in lagging chromosomes and anaphase bridges. FBXO31 regulates mitosis in part by controlling the levels of FOXM1, a transcription factor and master regulator of mitosis. FBXO31 specifically interacts with FOXM1 during the G2/M transition, resulting in FOXM1 ubiquitination and degradation. FBXO31 depletion results in increased expression of FOXM1 transcriptional targets and mimics the FOXM1 overexpression. In contrast, co-depletion of FBXO31 and FOXM1 restores the genomic instability phenotype but not the delay in mitosis, indicating that FBXO31 probably has additional mitotic substrates. Thus, FBXO31 is the first described negative regulator of FOXM1 during the G2/M transition. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
700 | 1 | a Kalimutho, M4 aut |
700 | 1 | a Johansson, Pegah,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine4 aut0 (Swepub:gu)xjopeg |
700 | 1 | a Cardenas, D G4 aut |
700 | 1 | a Kumar, R4 aut |
700 | 1 | a Khanna, K K4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin4 org |
773 | 0 | t Oncogened : Springer Science and Business Media LLCg 36, s. 1012-1022q 36<1012-1022x 1476-5594x 0950-9232 |
856 | 4 8 | u https://gup.ub.gu.se/publication/249811 |
856 | 4 8 | u https://doi.org/10.1038/onc.2016.268 |
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