onr:"swepub:oai:gup.ub.gu.se/254987"
Sökning: onr:"swepub:oai:gup.ub.gu.se/254987" > Cerebrospinal fluid...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Cerebrospinal fluid monoamine metabolite profiles in bipolar disorder, ADHD, and controls.
-
- Pålsson, Erik, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
-
- Sellgren, Carl (författare)
- Karolinska Institutet
- Rydén, Eleonore (författare)
- visa fler...
- Kizza, Ruth (författare)
- Pelanis, Aurimantas (författare)
- visa färre...
- (creator_code:org_t)
- 2017-06-27
- 2017
- Engelska.
- Ingår i: Journal of neural transmission (Vienna, Austria : 1996). - : Springer Science and Business Media LLC. - 1435-1463 .- 0300-9564. ; 124:9
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Alterations in monoaminergic signaling are suggested as key aspects of the pathophysiology in bipolar disorder and ADHD, but it is not known if the monoamine metabolic profile differs between these disorders. One method to study monoaminergic systems in humans is to measure monoamine end-point metabolite concentrations in cerebrospinal fluid (CSF). Here, we analyzed CSF monoamine metabolite concentrations in 103 adults with bipolar disorder, 72 adults with ADHD, and 113 controls. Individuals with bipolar disorder had significantly higher homovanillic acid (HVA, 264±112nmol/L, p<0.001) and 5-hydroxyindoleacetic acid (5-HIAA, 116±42nmol/L, p=0.001) concentration, but lower 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG, 38±8nmol/L, p<0.001) concentrations than controls (HVA, 206±70nmol/L; 5-HIAA, 98±31nmol/L; and MHPG, 42±7nmol/L). Higher HVA concentrations were associated with a history of psychosis in the bipolar disorder sample. Subjects with ADHD had higher HVA (240±94nmol/L, p<0.001) concentrations compared with controls. In addition, SSRI treatment was associated with lower 5-HIAA concentrations in both patient groups. A power analysis indicated that for within-group comparisons, only large effects would be reliably detectable. Thus, there may be moderate-to-small effects caused by medication that were not detected due to the limited size of the sub-groups in these analyses. In conclusion, the present study suggests disorder-specific alterations of CSF monoamine metabolite concentrations in patients with bipolar disorder and ADHD compared with controls; these differences were independent of acute symptoms and medication effects.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
- Journal of neural transmission (Vienna, Austria : 1996) (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Pålsson, Erik, 1 ...
- Sellgren, Carl
- Rydén, Eleonore
- Kizza, Ruth
- Pelanis, Auriman ...
- Zetterberg, Henr ...
- visa fler...
- Blennow, Kaj, 19 ...
- Landén, Mikael, ...
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Psykiatri
- Artiklar i publikationen
- Journal of neura ...
- Av lärosätet
- Göteborgs universitet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
