Search: onr:"swepub:oai:gup.ub.gu.se/258243" >
Sox5 regulates beta...
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
-
- Axelsson, Annika (author)
- University of Gothenburg,Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Diabetes - öcellsexocytos,Diabetes - Islet Cell Exocytosis,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Sage Bionetworks
-
- Mahdi, T (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Hawler Medical University
-
Nenonen, H. A. (author)
-
show more...
-
- Singh, Tania (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
-
- Hänzelmann, S (author)
- RWTH Aachen University
-
Wendt, A. (author)
-
- Bagge, Annika (author)
- Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups
-
Reinbothe, T. M. (author)
-
- Millstein, J. (author)
- Sage Bionetworks
-
- Yang, X (author)
- University of California, Los Angeles,Sage Bionetworks
-
- Zhang, B. (author)
- Sage Bionetworks,Icahn School of Medicine at Mount Sinai
-
- Gusmao, E. G. (author)
- RWTH Aachen University
-
- Shu, L. (author)
- University of California, Los Angeles
-
- Szabat, M. (author)
- University of British Columbia
-
- Tang, Y (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Tianjin Medical University
-
- Wang, Jinling (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Xiamen University
-
- Salö, S. (author)
- Lund University
-
- Eliasson, L (author)
- Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups
-
- Artner, I (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
-
- Fex, M (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Diabetes - molekylär metabolism,Celiac Disease and Diabetes Unit,Lund University Research Groups,Diabetes - Molecular Metabolism
-
- Johnson, J D (author)
- University of British Columbia
-
- Wollheim, C B (author)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University Medical Center, Geneva
-
Derry, J. M. J. (author)
-
- Mecham, B. (author)
- Trialomics
-
- Spégel, P (author)
- Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Diabetes - Molecular Metabolism,Lund University Research Groups,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
-
- Mulder, H (author)
- Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups
-
- Costa, I. G. (author)
- RWTH Aachen University
-
- Zhang, E (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
-
- Rosengren, Anders H., 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
-
show less...
-
(creator_code:org_t)
- 2017-06-06
- 2017
- English.
-
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
- Related links:
-
https://www.nature.c...
-
show more...
-
http://dx.doi.org/10... (free)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
show less...
Abstract
Subject headings
Close
- Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for genes with islet-selective open chromatin, is associated with T2D. These genes are perturbed in T2D and have a similar expression pattern to that of dedifferentiated islets. We identify Sox5 as a regulator of the module. Sox5 knockdown induces gene expression changes similar to those observed in T2D and diabetic animals and has profound effects on insulin secretion, including reduced depolarization-evoked Ca 2+-influx and β-cell exocytosis. SOX5 overexpression reverses the expression perturbations observed in a mouse model of T2D, increases the expression of key β-cell genes and improves glucose-stimulated insulin secretion in human islets from donors with T2D. We suggest that human islets in T2D display changes reminiscent of dedifferentiation and highlight SOX5 as a regulator of β-cell phenotype and function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Animalia
- Journal Article
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Axelsson, Annika
-
Mahdi, T
-
Nenonen, H. A.
-
Singh, Tania
-
Hänzelmann, S
-
Wendt, A.
-
show more...
-
Bagge, Annika
-
Reinbothe, T. M.
-
Millstein, J.
-
Yang, X
-
Zhang, B.
-
Gusmao, E. G.
-
Shu, L.
-
Szabat, M.
-
Tang, Y
-
Wang, Jinling
-
Salö, S.
-
Eliasson, L
-
Artner, I
-
Fex, M
-
Johnson, J D
-
Wollheim, C B
-
Derry, J. M. J.
-
Mecham, B.
-
Spégel, P
-
Mulder, H
-
Costa, I. G.
-
Zhang, E
-
Rosengren, Ander ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Nature Communica ...
- By the university
-
University of Gothenburg
-
Lund University