Sökning: onr:"swepub:oai:gup.ub.gu.se/261213" > Association of Poly...
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000 | 09017naa a2201681 4500 | |
001 | oai:gup.ub.gu.se/261213 | |
003 | SwePub | |
008 | 240910s2018 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:137400510 | |
024 | 7 | a https://gup.ub.gu.se/publication/2612132 URI |
024 | 7 | a https://doi.org/10.1001/jamapsychiatry.2017.34332 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1374005102 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Amare, Azmeraw T4 aut |
245 | 1 0 | a Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. |
264 | c 2017-11-09 | |
264 | 1 | b American Medical Association (AMA),c 2018 |
520 | a Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ).To test whether a polygenic score for SCZ is associated with treatment response to lithium in BPAD and to explore the potential molecular underpinnings of this association.A total of 2586 patients with BPAD who had undergone lithium treatment were genotyped and assessed for long-term response to treatment between 2008 and 2013. Weighted SCZ polygenic scores were computed at different P value thresholds using summary statistics from an international multicenter genome-wide association study (GWAS) of 36989 individuals with SCZ and genotype data from patients with BPAD from the Consortium on Lithium Genetics. For functional exploration, a cross-trait meta-GWAS and pathway analysis was performed, combining GWAS summary statistics on SCZ and response to treatment with lithium. Data analysis was performed from September 2016 to February 2017.Treatment response to lithium was defined on both the categorical and continuous scales using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. The effect measures include odds ratios and the proportion of variance explained.Of the 2586 patients in the study (mean [SD] age, 47.2 [13.9] years), 1478 were women and 1108 were men. The polygenic score for SCZ was inversely associated with lithium treatment response in the categorical outcome, at a threshold P<5×10-2. Patients with BPAD who had a low polygenic load for SCZ responded better to lithium, with odds ratios for lithium response ranging from 3.46 (95% CI, 1.42-8.41) at the first decile to 2.03 (95% CI, 0.86-4.81) at the ninth decile, compared with the patients in the 10th decile of SCZ risk. In the cross-trait meta-GWAS, 15 genetic loci that may have overlapping effects on lithium treatment response and susceptibility to SCZ were identified. Functional pathway and network analysis of these loci point to the HLA antigen complex and inflammatory cytokines.This study provides evidence for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPAD. These results suggest the potential for translational research aimed at personalized prescribing of lithium. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
700 | 1 | a Schubert, Klaus Oliver4 aut |
700 | 1 | a Hou, Liping4 aut |
700 | 1 | a Clark, Scott R4 aut |
700 | 1 | a Papiol, Sergi4 aut |
700 | 1 | a Heilbronner, Urs4 aut |
700 | 1 | a Degenhardt, Franziska4 aut |
700 | 1 | a Tekola-Ayele, Fasil4 aut |
700 | 1 | a Hsu, Yi-Hsiang4 aut |
700 | 1 | a Shekhtman, Tatyana4 aut |
700 | 1 | a Adli, Mazda4 aut |
700 | 1 | a Akula, Nirmala4 aut |
700 | 1 | a Akiyama, Kazufumi4 aut |
700 | 1 | a Ardau, Raffaella4 aut |
700 | 1 | a Arias, Bárbara4 aut |
700 | 1 | a Aubry, Jean-Michel4 aut |
700 | 1 | a Backlund, Lenau Karolinska Institutet4 aut |
700 | 1 | a Bhattacharjee, Abesh Kumar4 aut |
700 | 1 | a Bellivier, Frank4 aut |
700 | 1 | a Benabarre, Antonio4 aut |
700 | 1 | a Bengesser, Susanne4 aut |
700 | 1 | a Biernacka, Joanna M4 aut |
700 | 1 | a Birner, Armin4 aut |
700 | 1 | a Brichant-Petitjean, Clara4 aut |
700 | 1 | a Cervantes, Pablo4 aut |
700 | 1 | a Chen, Hsi-Chung4 aut |
700 | 1 | a Chillotti, Caterinau Karolinska Institutet4 aut |
700 | 1 | a Cichon, Sven4 aut |
700 | 1 | a Cruceanu, Cristiana4 aut |
700 | 1 | a Czerski, Piotr M4 aut |
700 | 1 | a Dalkner, Nina4 aut |
700 | 1 | a Dayer, Alexandre4 aut |
700 | 1 | a Del Zompo, Maria4 aut |
700 | 1 | a DePaulo, J Raymond4 aut |
700 | 1 | a Étain, Bruno4 aut |
700 | 1 | a Falkai, Peter4 aut |
700 | 1 | a Forstner, Andreas J4 aut |
700 | 1 | a Frisen, Louiseu Karolinska Institutet4 aut |
700 | 1 | a Frye, Mark A4 aut |
700 | 1 | a Fullerton, Janice M4 aut |
700 | 1 | a Gard, Sébastien4 aut |
700 | 1 | a Garnham, Julie S4 aut |
700 | 1 | a Goes, Fernando S4 aut |
700 | 1 | a Grigoroiu-Serbanescu, Maria4 aut |
700 | 1 | a Grof, Paul4 aut |
700 | 1 | a Hashimoto, Ryota4 aut |
700 | 1 | a Hauser, Joanna4 aut |
700 | 1 | a Herms, Stefan4 aut |
700 | 1 | a Hoffmann, Per4 aut |
700 | 1 | a Hofmann, Andrea4 aut |
700 | 1 | a Jamain, Stephane4 aut |
700 | 1 | a Jiménez, Esther4 aut |
700 | 1 | a Kahn, Jean-Pierre4 aut |
700 | 1 | a Kassem, Layla4 aut |
700 | 1 | a Kuo, Po-Hsiu4 aut |
700 | 1 | a Kato, Tadafumi4 aut |
700 | 1 | a Kelsoe, John4 aut |
700 | 1 | a Kittel-Schneider, Sarah4 aut |
700 | 1 | a Kliwicki, Sebastian4 aut |
700 | 1 | a König, Barbara4 aut |
700 | 1 | a Kusumi, Ichiro4 aut |
700 | 1 | a Laje, Gonzalo4 aut |
700 | 1 | a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
700 | 1 | a Lavebratt, Catharina4 aut |
700 | 1 | a Leboyer, Marion4 aut |
700 | 1 | a Leckband, Susan G4 aut |
700 | 1 | a Tortorella, Alfonso4 aut |
700 | 1 | a Manchia, Mirkou Karolinska Institutet4 aut |
700 | 1 | a Martinsson, Linau Karolinska Institutet4 aut |
700 | 1 | a McCarthy, Michael J4 aut |
700 | 1 | a McElroy, Susan4 aut |
700 | 1 | a Colom, Francesc4 aut |
700 | 1 | a Mitjans, Marina4 aut |
700 | 1 | a Mondimore, Francis M4 aut |
700 | 1 | a Monteleone, Palmiero4 aut |
700 | 1 | a Nievergelt, Caroline M4 aut |
700 | 1 | a Nöthen, Markus M4 aut |
700 | 1 | a Novák, Tomas4 aut |
700 | 1 | a O'Donovan, Claire4 aut |
700 | 1 | a Ozaki, Norio4 aut |
700 | 1 | a Ösby, Urban4 aut |
700 | 1 | a Pfennig, Andrea4 aut |
700 | 1 | a Potash, James B4 aut |
700 | 1 | a Reif, Andreas4 aut |
700 | 1 | a Reininghaus, Eva4 aut |
700 | 1 | a Rouleau, Guy A4 aut |
700 | 1 | a Rybakowski, Janusz K4 aut |
700 | 1 | a Schalling, Martin4 aut |
700 | 1 | a Schofield, Peter R4 aut |
700 | 1 | a Schweizer, Barbara W4 aut |
700 | 1 | a Severino, Giovanni4 aut |
700 | 1 | a Shilling, Paul D4 aut |
700 | 1 | a Shimoda, Katzutaka4 aut |
700 | 1 | a Simhandl, Christian4 aut |
700 | 1 | a Slaney, Claire M4 aut |
700 | 1 | a Squassina, Alessio4 aut |
700 | 1 | a Stamm, Thomas4 aut |
700 | 1 | a Stopkova, Pavla4 aut |
700 | 1 | a Maj, Mario4 aut |
700 | 1 | a Turecki, Gustavo4 aut |
700 | 1 | a Vieta, Eduard4 aut |
700 | 1 | a Volkert, Julia4 aut |
700 | 1 | a Witt, Stephanie4 aut |
700 | 1 | a Wright, Adam4 aut |
700 | 1 | a Zandi, Peter P4 aut |
700 | 1 | a Mitchell, Philip B4 aut |
700 | 1 | a Bauer, Michael4 aut |
700 | 1 | a Alda, Martin4 aut |
700 | 1 | a Rietschel, Marcella4 aut |
700 | 1 | a McMahon, Francis J4 aut |
700 | 1 | a Schulze, Thomas G4 aut |
700 | 1 | a Baune, Bernhard T4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t JAMA psychiatryd : American Medical Association (AMA)g 75:1, s. 65-74q 75:1<65-74x 2168-6238x 2168-622X |
856 | 4 | u https://jamanetwork.com/journals/jamapsychiatry/articlepdf/2663274/jamapsychiatry_amare_2017_oi_170082.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/261213 |
856 | 4 8 | u https://doi.org/10.1001/jamapsychiatry.2017.3433 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:137400510 |
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