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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006002naa a2201033 4500
001oai:gup.ub.gu.se/273390
003SwePub
008240528s2012 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:4382f9cf-43de-4e7b-b564-25e29382efb8
009oai:prod.swepub.kib.ki.se:124340793
009oai:DiVA.org:umu-55296
0247 a https://gup.ub.gu.se/publication/2733902 URI
0247 a https://doi.org/10.1002/ijc.262442 DOI
0247 a https://lup.lub.lu.se/record/25873992 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1243407932 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-552962 URI
040 a (SwePub)gud (SwePub)lud (SwePub)kid (SwePub)umu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Grote, Verena A.4 aut
2451 0a The association of circulating adiponectin levels with pancreatic cancer risk: A study within the prospective EPIC cohort
264 c 2011-09-17
264 1b Wiley,c 2012
520 a Excess body weight and type 2 diabetes mellitus, risk factors of pancreatic cancer, are characterized by decreased levels of adiponectin. In addition to anti-inflammatory and anti-proliferative actions, adiponectin has an important role in regulating glucose metabolism, i.e., decreasing circulating blood glucose levels. Prospectively, hyperglycemia has been associated with risk of pancreatic cancer. The aim of this study was to investigate the association of pre-diagnostic adiponectin levels with pancreatic cancer risk. We conducted a case-control study nested within European Prospective Investigation into Cancer and Nutrition. Blood samples of 452 pancreatic cancer cases and 452 individually matched controls were analyzed by immunoassays. Multivariate conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Overall, adiponectin showed no association with pancreas cancer risk; however, among never smokers, higher circulating levels of adiponectin were associated with a reduction in pancreatic cancer risk (OR = 0.44 [95% CI 0.23-0.82] for highest vs. lowest quartile), whereas among current smokers there was no significant association (OR = 1.59 [95% CI 0.67-3.76] for highest vs. lowest quartile; p-trend = 0.530; p-interaction = 0.309). In our study, lower adiponectin concentrations may be associated with the development of pancreatic cancer among never smokers, whereas the only other prospective study being conducted so far showed a decrease in risk among male smokers. Therefore, further studies are needed to clarify the role of adiponectin in pancreatic cancer development. © 2011 UICC.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a adiponectin
653 a cohort study
653 a EPIC
653 a pancreatic cancer
653 a adiponectin
7001 a Rohrmann, Sabine4 aut
7001 a Dossus, Laure4 aut
7001 a Nieters, Alexandra4 aut
7001 a Halkjær, Jytte4 aut
7001 a Tjønneland, Anne4 aut
7001 a Overvad, Kim4 aut
7001 a Stegger, Jakob4 aut
7001 a Chabbert-Buffet, Nathalie4 aut
7001 a Boutron-Ruault, Marie Christine4 aut
7001 a Clavel-Chapelon, Françoise4 aut
7001 a Teucher, Birgit4 aut
7001 a Becker, Susen4 aut
7001 a Montonen, Jukka4 aut
7001 a Boeing, Heiner4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Lagiou, Pagona4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Palli, Domenico4 aut
7001 a Sieri, Sabina4 aut
7001 a Tumino, Rosario4 aut
7001 a Vineis, Paolo4 aut
7001 a Mattiello, Amalia4 aut
7001 a Argüelles, Marcial4 aut
7001 a Duell, Eric J.4 aut
7001 a Molina-Montes, Esther4 aut
7001 a Larrañaga, Nerea4 aut
7001 a Chirlaque, María Dolores4 aut
7001 a Gurrea, Aurelio Barricarte4 aut
7001 a Jeurnink, Suzanne M.4 aut
7001 a Peeters, Petra H.M.4 aut
7001 a Ye, Weiminu Karolinska Institutet4 aut
7001 a Sund, Malinu Umeå universitet,Kirurgi,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)masu0021
7001 a Lindkvist, Björnu Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xlibjo
7001 a Johansen, Dortheu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kirm-djo
7001 a Khaw, Kay Tee4 aut
7001 a Wareham, Nick4 aut
7001 a Crowe, Francesca L.4 aut
7001 a Romieu, Isabelle4 aut
7001 a Rinaldi, Sabina4 aut
7001 a Jenab, Mazda4 aut
7001 a Romaguera, Dora4 aut
7001 a Michaud, Dominique S.4 aut
7001 a Riboli, Elio4 aut
7001 a Bas Bueno-De-Mesquita, H.4 aut
7001 a Kaaks, Rudolf4 aut
7102 a Karolinska Institutetb Kirurgi4 org
7730 t International Journal of Cancerd : Wileyg 130, s. 2428-2437q 130<2428-2437x 0020-7136x 1097-0215
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.26244
8564 u http://dx.doi.org/10.1002/ijc.26244y FULLTEXT
8564 8u https://gup.ub.gu.se/publication/273390
8564 8u https://doi.org/10.1002/ijc.26244
8564 8u https://lup.lub.lu.se/record/2587399
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:124340793
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-55296

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