Sökning: onr:"swepub:oai:gup.ub.gu.se/279316" > Gordon Smith Katherine > Contribution of Rar...
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000 | 05089naa a2200853 4500 | |
001 | oai:gup.ub.gu.se/279316 | |
003 | SwePub | |
008 | 240910s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:141238385 | |
024 | 7 | a https://gup.ub.gu.se/publication/2793162 URI |
024 | 7 | a https://doi.org/10.1016/j.biopsych.2018.12.0092 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1412383852 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Charney, Alexander W4 aut |
245 | 1 0 | a Contribution of Rare Copy Number Variants toBipolar Disorder Risk Is Limited to Schizoaffective Cases. |
264 | 1 | b Elsevier BV,c 2019 |
520 | a Genetic risk for bipolar disorder (BD) is conferred through many common alleles, while a role for rare copy number variants (CNVs) is less clear. Subtypes of BD including schizoaffective disorder bipolar type (SAB), bipolar I disorder (BD I), and bipolar II disorder (BD II) differ according to the prominence and timing of psychosis, mania, and depression. The genetic factors contributing to the combination of symptoms among these subtypes are poorly understood.Rare large CNVs were analyzed in 6353 BD cases (3833 BD I [2676 with psychosis, 850 without psychosis, and 307 with unknown psychosis history], 1436 BD II, 579 SAB, and 505 BD not otherwise specified) and 8656 controls. CNV burden and a polygenic risk score (PRS) for schizophrenia were used to evaluate the relative contributions of rare and common variants to risk of BD, BD subtypes, and psychosis.CNV burden did not differ between BD and controls when treated as a single diagnostic entity. However, burden in SAB was increased relative to controls (p= .001), BD I (p= .0003), and BD II (p= .0007). Burden and schizophrenia PRSs were increased in SAB compared with BD I with psychosis (CNV p= .0007, PRS p= .004), and BD I without psychosis (CNV p= .0004, PRS p= 3.9× 10-5). Within BD I, psychosis was associated with increased schizophrenia PRSs (p= .005) but not CNV burden.CNV burden in BD is limited to SAB. Rare and common genetic variants may contribute differently to risk for psychosis and perhaps other classes of psychiatric symptoms. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
700 | 1 | a Stahl, Eli A4 aut |
700 | 1 | a Green, Elaine K4 aut |
700 | 1 | a Chen, Chia-Yen4 aut |
700 | 1 | a Moran, Jennifer Lu Karolinska Institutet4 aut |
700 | 1 | a Chambert, Kimberly4 aut |
700 | 1 | a Belliveau, Richard A4 aut |
700 | 1 | a Forty, Liz4 aut |
700 | 1 | a Gordon-Smith, Katherine4 aut |
700 | 1 | a Lee, Phil H4 aut |
700 | 1 | a Bromet, Evelyn J4 aut |
700 | 1 | a Buckley, Peter F4 aut |
700 | 1 | a Escamilla, Michael A4 aut |
700 | 1 | a Fanous, Ayman H4 aut |
700 | 1 | a Fochtmann, Laura J4 aut |
700 | 1 | a Lehrer, Douglas S4 aut |
700 | 1 | a Malaspina, Dolores4 aut |
700 | 1 | a Marder, Stephen R4 aut |
700 | 1 | a Morley, Christopher P4 aut |
700 | 1 | a Nicolini, Humberto4 aut |
700 | 1 | a Perkins, Diana O4 aut |
700 | 1 | a Rakofsky, Jeffrey J4 aut |
700 | 1 | a Rapaport, Mark H4 aut |
700 | 1 | a Medeiros, Helena4 aut |
700 | 1 | a Sobell, Janet L4 aut |
700 | 1 | a Backlund, Lenau Karolinska Institutet4 aut |
700 | 1 | a Bergen, Sarah Eu Karolinska Institutet4 aut |
700 | 1 | a Juréus, Anders4 aut |
700 | 1 | a Schalling, Martinu Karolinska Institutet4 aut |
700 | 1 | a Lichtenstein, Paulu Karolinska Institutet4 aut |
700 | 1 | a Knowles, James A4 aut |
700 | 1 | a Burdick, Katherine E4 aut |
700 | 1 | a Jones, Ian4 aut |
700 | 1 | a Jones, Lisa A4 aut |
700 | 1 | a Hultman, Christina Mu Karolinska Institutet4 aut |
700 | 1 | a Perlis, Roy4 aut |
700 | 1 | a Purcell, Shaun M4 aut |
700 | 1 | a McCarroll, Steven A4 aut |
700 | 1 | a Pato, Carlos N4 aut |
700 | 1 | a Pato, Michele T4 aut |
700 | 1 | a Di Florio, Ariana4 aut |
700 | 1 | a Craddock, Nick4 aut |
700 | 1 | a Landén, Mikael,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
700 | 1 | a Smoller, Jordan W4 aut |
700 | 1 | a Ruderfer, Douglas M4 aut |
700 | 1 | a Sklar, Pamela4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Biological psychiatryd : Elsevier BVg 86:2, s. 110-119q 86:2<110-119x 1873-2402x 0006-3223 |
856 | 4 | u https://cdr.lib.unc.edu/downloads/d504rv94j |
856 | 4 8 | u https://gup.ub.gu.se/publication/279316 |
856 | 4 8 | u https://doi.org/10.1016/j.biopsych.2018.12.009 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141238385 |
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