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High throughput pro...
High throughput proteomics identifies a high-accuracy 11 plasma protein biomarker signature for ovarian cancer
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- Enroth, Stefan, 1976- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Gyllensten
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- Berggrund, Malin (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
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- Lycke, Maria (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Broberg, J. (author)
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Lundberg, M. (author)
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Assarsson, E. (author)
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- Olovsson, Matts, 1958- (author)
- Uppsala universitet,Reproduktionsbiologi
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- Stålberg, Karin (author)
- Uppsala universitet,Reproduktiv hälsa
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- Sundfeldt, Karin, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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- Gyllensten, Ulf B. (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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(creator_code:org_t)
- 2019-06-20
- 2019
- English.
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In: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 2
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https://doi.org/10.1...
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Abstract
Subject headings
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- Ovarian cancer is usually detected at a late stage and the overall 5-year survival is only 30-40%. Additional means for early detection and improved diagnosis are acutely needed. To search for novel biomarkers, we compared circulating plasma levels of 593 proteins in three cohorts of patients with ovarian cancer and benign tumors, using the proximity extension assay (PEA). A combinatorial strategy was developed for identification of different multivariate biomarker signatures. A final model consisting of 11 biomarkers plus age was developed into a multiplex PEA test reporting in absolute concentrations. The final model was evaluated in a fourth independent cohort and has an AUC = 0.94, PPV = 0.92, sensitivity = 0.85 and specificity = 0.93 for detection of ovarian cancer stages I-IV. The novel plasma protein signature could be used to improve the diagnosis of women with adnexal ovarian mass or in screening to identify women that should be referred to specialized examination.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- multiple linear-regression
- folate receptor-alpha
- he-4
- size
- expression
- matriptase
- malignancy
- prognosis
- models
- target
- Life Sciences & Biomedicine
- Diagnostic markers
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Enroth, Stefan, ...
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Berggrund, Malin
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Lycke, Maria
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Broberg, J.
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Lundberg, M.
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Assarsson, E.
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show more...
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Olovsson, Matts, ...
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Stålberg, Karin
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Sundfeldt, Karin ...
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Gyllensten, Ulf ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Communications B ...
- By the university
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University of Gothenburg
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Uppsala University