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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004218naa a2200565 4500
001oai:gup.ub.gu.se/284771
003SwePub
008240528s2019 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2847712 URI
0247 a https://doi.org/10.3233/JAD-1905332 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Chatterjee, P.4 aut
2451 0a Ultrasensitive Detection of Plasma Amyloid-beta as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease
264 1c 2019
520 a Background: Aberrant amyloid-beta (A beta) deposition in the brain occurs two decades prior to the manifestation of Alzheimer's disease (AD) clinical symptoms and therefore brain A beta load measured using PET serves as a gold standard biomarker for the early diagnosis of AD. However, the uneconomical nature of PET makes blood markers, that reflect brain A beta deposition, attractive candidates for investigation as surrogate markers. Objective: Investigation of plasma A beta as a surrogate marker for brain A beta deposition in cognitively normal elderly individuals. Methods: Plasma A beta(40) and A beta(42) concentrations were measured using the ultrasensitive Single Molecule Array (Simoa) assay in 95 cognitively normal elderly individuals, who have all undergone PET to assess brain A beta deposition. Based on the standard uptake value ratios (SUVR) obtained from PET imaging, using the tracer F-18-Florbetaben, plasma A beta was compared between 32 participants assessed to have low brain A beta load (A beta-, SUVR <1.35) and 63 assessed to have high brain A beta load (A beta+, SUVR >= 1.35). Results: Plasma A beta(42)/A beta(40) ratios were lower in the A beta+ group compared to the A beta- group. Plasma A beta(40) and A beta(42) levels were not significantly different between A beta- and A beta+ groups, although a trend of higher plasma A beta(40) was observed in the A beta+ group. Additionally, plasma A beta(42)/A beta(40) ratios along with the known AD risk factors, age and APOE epsilon 4 status, resulted in A beta+ participants being distinguished from A beta- participants based on an area under the receiver operating characteristic curve shown to be 78%. Conclusion: Plasma A beta ratios in this study are a potential biomarker for brain A beta deposition and therefore, for preclinical AD. However, this method to measure plasma A beta needs further development to increase the accuracy of this promising AD blood biomarker.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a Alzheimer's disease
653 a blood biomarkers
653 a plasma amyloid-beta
653 a plasma amyloid-beta ratios
653 a preclinical
653 a dementia
653 a quantification
653 a association
653 a deposition
653 a decline
653 a Neurosciences & Neurology
7001 a Elmi, M.4 aut
7001 a Goozee, K.4 aut
7001 a Shah, T.4 aut
7001 a Sohrabi, H. R.4 aut
7001 a Dias, C. B.4 aut
7001 a Pedrini, S.4 aut
7001 a Shen, K.4 aut
7001 a Asih, P. R.4 aut
7001 a Dave, P.4 aut
7001 a Taddei, K.4 aut
7001 a Vanderstichele, H.4 aut
7001 a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xzethe
7001 a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xbleka
7001 a Martins, R. N.4 aut
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi4 org
7730 t Journal of Alzheimers Diseaseg 71:3, s. 775-783q 71:3<775-783x 1387-2877
8564 8u https://gup.ub.gu.se/publication/284771
8564 8u https://doi.org/10.3233/JAD-190533

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