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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04193naa a2200661 4500 | |
| 001 | oai:gup.ub.gu.se/293995 | |
| 003 | SwePub | |
| 008 | 240910s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2939952 URI |
| 024 | 7 | a https://doi.org/10.1093/cercor/bhz2282 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Fjell, A. M.4 aut |
| 245 | 1 0 | a Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression |
| 264 | c 2019-11-11 | |
| 264 | 1 | b Oxford University Press (OUP),c 2020 |
| 520 | a Sleep problems are related to the elevated levels of the Alzheimer's disease (AD) biomarker beta-amyloid (AD) Hypotheses about the causes of this relationship can be generated from molecular markers of sleep problems identified in rodents. A major marker of sleep deprivation is Homerla, a neural protein coded by the HOMER1 gene, which has also been implicated in brain A beta accumulation. Here, we tested whether the relationship between cortical A beta accumulation and self-reported sleep quality, as well as changes in sleep quality over 3 years, was stronger in cortical regions with high HOMER1 mRNA expression levels. In a sample of 154 cognitively healthy older adults, A beta correlated with poorer sleep quality cross-sectionally and longitudinally (n = 62), but more strongly in the younger than in older individuals. Effects were mainly found in regions with high expression of HOMER1. The anatomical distribution of the sleep-A beta relationship followed closely the A beta accumulation pattern in 69 patients with mild cognitive impairment or AD. Thus, the results indicate that the relationship between sleep problems and A beta accumulation may involve Homer1 activity in the cortical regions, where harbor A beta deposits in AD. The findings may advance our understanding of the relationship between sleep problems and AD risk. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a Alzheimer's disease | |
| 653 | a amyloid | |
| 653 | a gene expression | |
| 653 | a HOMER1 | |
| 653 | a sleep | |
| 653 | a surface-based analysis | |
| 653 | a alzheimers-disease | |
| 653 | a cerebral-cortex | |
| 653 | a hypothetical model | |
| 653 | a quality | |
| 653 | a beta | |
| 653 | a thickness | |
| 653 | a protein | |
| 653 | a body | |
| 653 | a neuroinflammation | |
| 653 | a Neurosciences & Neurology | |
| 700 | 1 | a Sederevicius, D.4 aut |
| 700 | 1 | a Sneve, M. H.4 aut |
| 700 | 1 | a De Lange, A. M. G.4 aut |
| 700 | 1 | a Brathen, A. C.4 aut |
| 700 | 1 | a Idland, A. V.4 aut |
| 700 | 1 | a Watne, L. O.4 aut |
| 700 | 1 | a Wang, Y. P.4 aut |
| 700 | 1 | a Reinbold, C.4 aut |
| 700 | 1 | a Dobricic, V.4 aut |
| 700 | 1 | a Kilpert, F.4 aut |
| 700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Hong, S. J.4 aut |
| 700 | 1 | a Bertram, L.4 aut |
| 700 | 1 | a Walhovd, K. B.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Cerebral Cortexd : Oxford University Press (OUP)g 30:4, s. 2144-2156q 30:4<2144-2156x 1047-3211x 1460-2199 |
| 856 | 4 | u https://academic.oup.com/cercor/article-pdf/30/4/2144/33112240/bhz228.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/293995 |
| 856 | 4 8 | u https://doi.org/10.1093/cercor/bhz228 |
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