Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology.

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Fältnamn	Indikatorer	Metadata
000		09060naa a2201237 4500
001		oai:gup.ub.gu.se/295674
003		SwePub
008		240528s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:oru-85111
009		oai:prod.swepub.kib.ki.se:145020231
024	7	a https://gup.ub.gu.se/publication/2956742 URI
024	7	a https://doi.org/10.3233/JAD-2002082 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-851112 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1450202312 URI
040		a (SwePub)gud (SwePub)orud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Shi, Liuu Department of Psychiatry, University of Oxford, UK4 aut
245	1 0	a Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology.
264	1	b IOS Press,c 2020
500		a Funding Agencies:Innovative Medicines Initiative Joint Undertaking under EMIF from the European Union's Seventh Framework Programme (FP7/2007-2013) 115372EFPIA companies' European CommissionEuropean Commission Joint Research CentreEuropean Union (EU) QLRT-20012455 37670Stichting voor Alzheimer Onderzoek 11020 13007 15005Swiss National Science Foundation (SNSF) SNF 320030 141179Department of Health of the Basque Government 17.0.1.08.12.0000.2.454.01.41142.001.HUniversity of Antwerp Research Fund NIHR biomedical research centre at UCLH Health Data Research UK National Institute for Health Research (NIHR)Maudsley NHS Foundation Trust King's College London NIHR University College London Hospitals Biomedical Research Centre DPUK through MRC MR/L023784/2Medical Research Council UK (MRC) MC PC 17215NIHR Biomedical Research Centre at Oxford Health NHS Foundation Trust
520		a Previous studies suggest that Dickkopf-1 (DKK1), an inhibitor of Wnt signaling, plays a role in amyloid-induced toxicity and hence Alzheimer's disease (AD). However, the effect of DKK1 expression on protein expression, and whether such proteins are altered in disease, is unknown.We aim to test whether DKK1 induced protein signature obtained in vitro were associated with markers of AD pathology as used in the amyloid/tau/neurodegeneration (ATN) framework as well as with clinical outcomes.We first overexpressed DKK1 in HEK293A cells and quantified 1,128 proteins in cell lysates using aptamer capture arrays (SomaScan) to obtain a protein signature induced by DKK1. We then used the same assay to measure the DKK1-signature proteins in human plasma in two large cohorts, EMIF (n = 785) and ANM (n = 677).We identified a 100-protein signature induced by DKK1 in vitro. Subsets of proteins, along with age and apolipoprotein E ɛ4 genotype distinguished amyloid pathology (A + T-N-, A+T+N-, A+T-N+, and A+T+N+) from no AD pathology (A-T-N-) with an area under the curve of 0.72, 0.81, 0.88, and 0.85, respectively. Furthermore, we found that some signature proteins (e.g., Complement C3 and albumin) were associated with cognitive score and AD diagnosis in both cohorts.Our results add further evidence for a role of DKK regulation of Wnt signaling in AD and suggest that DKK1 induced signature proteins obtained in vitro could reflect theATNframework as well as predict disease severity and progression in vivo.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
653		a ATN framework
700	1	a Winchester, Laura M4 aut
700	1	a Liu, Benjamine Y4 aut
700	1	a Killick, Richard4 aut
700	1	a Ribe, Elena M4 aut
700	1	a Westwood, Sarah4 aut
700	1	a Baird, Alison L4 aut
700	1	a Buckley, Noel J4 aut
700	1	a Hong, Shengjun4 aut
700	1	a Dobricic, Valerija4 aut
700	1	a Kilpert, Fabian4 aut
700	1	a Franke, Andre4 aut
700	1	a Kiddle, Steven4 aut
700	1	a Sattlecker, Martina4 aut
700	1	a Dobson, Richard4 aut
700	1	a Cuadrado, Antonio4 aut
700	1	a Hye, Abdul4 aut
700	1	a Ashton, Nicholas J.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xashtn
700	1	a Morgan, Angharad R4 aut
700	1	a Bos, Isabelle4 aut
700	1	a Vos, Stephanie J B4 aut
700	1	a Ten Kate, Mara4 aut
700	1	a Scheltens, Philip4 aut
700	1	a Vandenberghe, Rik4 aut
700	1	a Gabel, Silvy4 aut
700	1	a Meersmans, Karen4 aut
700	1	a Engelborghs, Sebastiaan4 aut
700	1	a De Roeck, Ellen E4 aut
700	1	a Sleegers, Kristel4 aut
700	1	a Frisoni, Giovanni B4 aut
700	1	a Blin, Olivier4 aut
700	1	a Richardson, Jill C4 aut
700	1	a Bordet, Régis4 aut
700	1	a Molinuevo, José L4 aut
700	1	a Rami, Lorena4 aut
700	1	a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xwaand
700	1	a Kettunen, Petronellau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xketpe
700	1	a Tsolaki, Magda4 aut
700	1	a Verhey, Frans4 aut
700	1	a Lleó, Alberto4 aut
700	1	a Alcolea, Daniel4 aut
700	1	a Popp, Juliusu Karolinska Institutet4 aut
700	1	a Peyratout, Gwendoline4 aut
700	1	a Martinez-Lage, Pablo4 aut
700	1	a Tainta, Mikel4 aut
700	1	a Johannsen, Peter4 aut
700	1	a Teunissen, Charlotte E4 aut
700	1	a Freund-Levi, Yvonne,d 1956-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institute, Stockholm, Sweden; Department of Old Age Psychiatry, Psychology and Neuroscience, King's College London, UK; Department of Psychiatry, Örebro Universitetssjukhus, Örebro, Sweden4 aut0 (Swepub:oru)yfi
700	1	a Frölich, Lutz4 aut
700	1	a Legido-Quigley, Cristina4 aut
700	1	a Barkhof, Frederik4 aut
700	1	a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka
700	1	a Rasmussen, Katrine Laura4 aut
700	1	a Nordestgaard, Børge Grønne4 aut
700	1	a Frikke-Schmidt, Ruth4 aut
700	1	a Nielsen, Sune Fallgaard4 aut
700	1	a Soininen, Hilkka4 aut
700	1	a Vellas, Bruno4 aut
700	1	a Kloszewska, Iwona4 aut
700	1	a Mecocci, Patrizia4 aut
700	1	a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe
700	1	a Morgan, B Paul4 aut
700	1	a Streffer, Johannes4 aut
700	1	a Visser, Pieter Jelle4 aut
700	1	a Bertram, Lars4 aut
700	1	a Nevado-Holgado, Alejo J4 aut
700	1	a Lovestone, Simonu Department of Psychiatry, University of Oxford, UK4 aut
710	2	a Department of Psychiatry, University of Oxford, UKb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Journal of Alzheimer's disease : JADd : IOS Pressg 77:3, s. 1353-1368q 77:3<1353-1368x 1875-8908x 1387-2877
856	4	u https://doi.org/10.3233/JAD-200208y Fulltext
856	4 8	u https://gup.ub.gu.se/publication/295674
856	4 8	u https://doi.org/10.3233/JAD-200208
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-85111
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:145020231

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Av författaren/redakt...: Shi, Liu; Winchester, Laur ...; Liu, Benjamine Y; Killick, Richard; Ribe, Elena M; Westwood, Sarah; visa fler...; Baird, Alison L; Buckley, Noel J; Hong, Shengjun; Dobricic, Valeri ...; Kilpert, Fabian; Franke, Andre; Kiddle, Steven; Sattlecker, Mart ...; Dobson, Richard; Cuadrado, Antoni ...; Hye, Abdul; Ashton, Nicholas ...; Morgan, Angharad ...; Bos, Isabelle; Vos, Stephanie J ...; Ten Kate, Mara; Scheltens, Phili ...; Vandenberghe, Ri ...; Gabel, Silvy; Meersmans, Karen; Engelborghs, Seb ...; De Roeck, Ellen ...; Sleegers, Kriste ...; Frisoni, Giovann ...; Blin, Olivier; Richardson, Jill ...; Bordet, Régis; Molinuevo, José ...; Rami, Lorena; Wallin, Anders, ...; Kettunen, Petron ...; Tsolaki, Magda; Verhey, Frans; Lleó, Alberto; Alcolea, Daniel; Popp, Julius; Peyratout, Gwend ...; Martinez-Lage, P ...; Tainta, Mikel; Johannsen, Peter; Teunissen, Charl ...; Freund-Levi, Yvo ...; Frölich, Lutz; Legido-Quigley, ...; Barkhof, Frederi ...; Blennow, Kaj, 19 ...; Rasmussen, Katri ...; Nordestgaard, Bø ...; Frikke-Schmidt, ...; Nielsen, Sune Fa ...; Soininen, Hilkka; Vellas, Bruno; Kloszewska, Iwon ...; Mecocci, Patrizi ...; Zetterberg, Henr ...; Morgan, B Paul; Streffer, Johann ...; Visser, Pieter J ...; Bertram, Lars; Nevado-Holgado, ...; Lovestone, Simon; visa färre...

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