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FältnamnIndikatorerMetadata
00006209naa a2200733 4500
001oai:gup.ub.gu.se/296173
003SwePub
008240528s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-166185
024a https://gup.ub.gu.se/publication/2961732 URI
024a https://doi.org/10.1007/s00125-020-05152-12 DOI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1661852 URI
040 a (SwePub)gud (SwePub)liu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Cherubini, V.u Salesi Hosp, Italy4 aut
2451 0a Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016: results from 13 countries in three continents
264 c 2020-05-08
264 1b Springer Science and Business Media LLC,c 2020
500 a Funding Agencies|Projekt DEAL
520 a Aims/hypothesis: The aim of this work was to evaluate geographical variability and trends in the prevalence of diabetic ketoacidosis (DKA), between 2006 and 2016, at the diagnosis of childhood-onset type 1 diabetes in 13 countries over three continents. Methods: An international retrospective study on DKA at diagnosis of diabetes was conducted. Data on age, sex, date of diabetes diagnosis, ethnic minority status and presence of DKA at diabetes onset were obtained from Australia, Austria, Czechia, Denmark, Germany, Italy, Luxembourg, New Zealand, Norway, Slovenia, Sweden, USA and the UK (Wales). Mean prevalence was estimated for the entire period, both overall and by country, adjusted for sex and age group. Temporal trends in annual prevalence of DKA were estimated using logistic regression analysis for each country, before and after adjustment for sex, age group and ethnic minority status. Results: During the study period, new-onset type 1 diabetes was diagnosed in 59,000 children (median age [interquartile range], 9.0years [5.5–11.7]; male sex, 52.9%). The overall adjusted DKA prevalence was 29.9%, with the lowest prevalence in Sweden and Denmark and the highest in Luxembourg and Italy. The adjusted DKA prevalence significantly increased over time in Australia, Germany and the USA while it decreased in Italy. Preschool children, adolescents and children from ethnic minority groups were at highest risk of DKA at diabetes diagnosis in most countries. A significantly higher risk was also found for females in Denmark, Germany and Slovenia. Conclusions/interpretation: DKA prevalence at type 1 diabetes diagnosis varied considerably across countries, albeit it was generally high and showed a slight increase between 2006 and 2016. Increased awareness of symptoms to prevent delay in diagnosis is warranted, especially in preschool children, adolescents and children from ethnic minority groups. © 2020, The Author(s).
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Children with diabetes
653 a Complications
653 a Diabetic ketoacidosis
653 a Diagnosis of diabetes
653 a Epidemiology
653 a Type 1 diabetes
653 a Children with diabetes; Complications; Diabetic ketoacidosis; Diagnosis of diabetes; Epidemiology; Type 1 diabetes
700a Grimsmann, J. M.u Univ Ulm, Germany; German Ctr Diabet Res DZD, Germany4 aut
700a Åkesson, Karinu Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Ryhov Cty Hosp, Sweden4 aut0 (Swepub:liu)karak14
700a Birkebæk, N. H.u Aarhus Univ Hosp, Denmark4 aut
700a Cinek, O.u Charles Univ Prague, Czech Republic; Motol Univ Hosp, Czech Republic4 aut
700a Dovč, K.u UMC Univ Childrens Hosp, Slovenia; Fac Med, Slovenia4 aut
700a Gesuita, R.u Polytech Univ Marche, Italy4 aut
700a Gregory, J. W.u Cardiff Univ, Wales4 aut
700a Hanås, Ragnar,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,NU Hosp Grp, Sweden; Gothenburg Univ, Sweden4 aut0 (Swepub:gu)xhanra
700a Hofer, S. E.u Med Univ Innsbruck, Austria4 aut
700a Holl, R. W.u Univ Ulm, Germany; German Ctr Diabet Res DZD, Germany4 aut
700a Jefferies, C.u Starship Childrens Hlth, New Zealand4 aut
700a Joner, G.u Oslo Univ Hosp, Norway; Univ Oslo, Norway4 aut
700a King, B. R.u Univ Newcastle, Australia4 aut
700a Mayer-Davis, E. J.u Univ N Carolina, NC 27515 USA4 aut
700a Peña, A. S.u Univ Adelaide, Australia4 aut
700a Rami-Merhar, B.u Med Univ Vienna, Austria4 aut
700a Schierloh, U.u Ctr Hosp, Luxembourg4 aut
700a Skrivarhaug, T.u Oslo Univ Hosp, Norway; Univ Oslo, Norway4 aut
700a Sumnik, Z.u Charles Univ Prague, Czech Republic; Motol Univ Hosp, Czech Republic4 aut
700a Svensson, J.u Copenhagen Univ Hosp, Denmark4 aut
700a Warner, J. T.u Univ Hosp Wales, Wales4 aut
700a Bratina, N.u UMC Univ Childrens Hosp, Slovenia; Fac Med, Slovenia4 aut
700a Dabelea, D.u Univ Colorado, CO USA4 aut
710a Salesi Hosp, Italyb Univ Ulm, Germany; German Ctr Diabet Res DZD, Germany4 org
773t Diabetologiad : Springer Science and Business Media LLCg 63, s. 1530-1541q 63<1530-1541x 0012-186Xx 1432-0428
856u https://link.springer.com/content/pdf/10.1007/s00125-020-05152-1.pdf
856u https://liu.diva-portal.org/smash/get/diva2:1437701/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/296173
8564 8u https://doi.org/10.1007/s00125-020-05152-1
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166185

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