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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04782naa a2200781 4500 | |
| 001 | oai:gup.ub.gu.se/297724 | |
| 003 | SwePub | |
| 008 | 240910s2020 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:144808033 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2977242 URI |
| 024 | 7 | a https://doi.org/10.1093/rheumatology/kez6562 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1448080332 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Michelsen, B.4 aut |
| 245 | 1 0 | a Impact of discordance between patient's and evaluator's global assessment on treatment outcomes in 14 868 patients with spondyloarthritis |
| 264 | c 2020-01-20 | |
| 264 | 1 | b Oxford University Press (OUP),c 2020 |
| 520 | a Objectives. To assess the impact of 'patient's minus evaluator's global assessment of disease activity' (Delta PEG) at treatment initiation on retention and remission rates of TNF inhibitors (TNFi) in psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) patients across Europe. Methods. Real-life data from PsA and axSpA patients starting their first TNFi from 11 countries in the European Spondyloarthritis Research Collaboration Network were pooled. Retention rates were compared by Kaplan-Meier analyses with log-rank test and by Cox regression, and remission rates by chi(2) test and by logistic regression across quartiles of baseline Delta PEG, separately in female and male PsA and axSpA patients. Results. We included 14 868 spondyloarthritis (5855 PsA, 9013 axSpA) patients. Baseline Delta PEG was negatively associated with 6/12/24-months' TNFi retention rates in female and male PsA and axSpA patients (P < 0.001), with 6/12/24-months' BASDAI < 2 (P <= 0.002) and ASDAS < 1.3 (P <= 0.005) in axSpA patients, and with DAS28CRP(4)<2.6 (P <= 0.04) and DAPSA28 <= 4 (P <= 0.01), but not DAS28CRP(3)<2.6 (P >= 0.13) in PsA patients, with few exceptions on remission rates. Retention and remission rates were overall lower in female than male patients. Conclusion. High baseline patient's compared with evaluator's global assessment was associated with lower 6/12/24-months' remission as well as retention rates of first TNFi in both PsA and axSpA patients. These results highlight the importance of discordance between patient's and evaluator's perspective on disease outcomes. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
| 653 | a axial spondyloarthritis | |
| 653 | a psoriatic arthritis | |
| 653 | a TNF inhibitors | |
| 653 | a treatment | |
| 653 | a outcomes | |
| 653 | a psoriatic-arthritis | |
| 653 | a physician | |
| 653 | a Rheumatology | |
| 700 | 1 | a Ornbjerg, L. M.4 aut |
| 700 | 1 | a Kvien, T. K.4 aut |
| 700 | 1 | a Pavelka, K.4 aut |
| 700 | 1 | a Nissen, M. J.4 aut |
| 700 | 1 | a Nordstrom, D.4 aut |
| 700 | 1 | a Santos, M. J.4 aut |
| 700 | 1 | a Koca, S. S.4 aut |
| 700 | 1 | a Askling, J.u Karolinska Institutet4 aut |
| 700 | 1 | a Rotar, Z.4 aut |
| 700 | 1 | a Gudbjornsson, B.4 aut |
| 700 | 1 | a Codreanu, C.4 aut |
| 700 | 1 | a Loft, A. G.4 aut |
| 700 | 1 | a Kristianslund, E. K.4 aut |
| 700 | 1 | a Mann, H. F.4 aut |
| 700 | 1 | a Ciurea, A.4 aut |
| 700 | 1 | a Eklund, K. K.4 aut |
| 700 | 1 | a Vieira-Sousa, E.4 aut |
| 700 | 1 | a Yazici, A.4 aut |
| 700 | 1 | a Jacobsson, Lennart T. H.,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xjacle |
| 700 | 1 | a Tomsic, M.4 aut |
| 700 | 1 | a Love, T. J.4 aut |
| 700 | 1 | a Ionescu, R.4 aut |
| 700 | 1 | a van der Horst-Bruinsma, I. E.4 aut |
| 700 | 1 | a Iannone, F.4 aut |
| 700 | 1 | a Pombo-Suarez, M.4 aut |
| 700 | 1 | a Jones, G. T.4 aut |
| 700 | 1 | a Hyldstrup, L. H.4 aut |
| 700 | 1 | a Krogh, N. S.4 aut |
| 700 | 1 | a Hetland, M. L.4 aut |
| 700 | 1 | a Ostergaard, M.4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning4 org |
| 773 | 0 | t Rheumatologyd : Oxford University Press (OUP)g 59:9, s. 2455-2461q 59:9<2455-2461x 1462-0324x 1462-0332 |
| 856 | 4 | u https://repositorio.ul.pt/bitstream/10451/46731/1/Impact_discordance.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/297724 |
| 856 | 4 8 | u https://doi.org/10.1093/rheumatology/kez656 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144808033 |
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