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Value of flow cytom...
Value of flow cytometry for MRD-based relapse prediction in B-cell precursor ALL in a multicenter setting.
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- Modvig, S (author)
- Copenhagen University Hospital,Vilnius University,Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.,Vilnius Univ Hosp, Santaros Klin, Hematol Oncol & Transfus Med Ctr, Vilnius, Lithuania.
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- Hallböök, Helene (author)
- Uppsala universitet,Uppsala University,Copenhagen University Hospital,Oslo university hospital,Hematologi,Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.,Oslo Univ Hosp, Dept Pathol, Lab Mol Pathol, Oslo, Norway.
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- Madsen, H O (author)
- Umeå University,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden.
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- Siitonen, S (author)
- University of Helsinki,University of Copenhagen,Univ Helsinki, Clin Chem, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.,Univ Copenhagen, Sect Biostat, Copenhagen, Denmark.
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Rosthøj, S (author)
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- Tierens, A (author)
- University of Toronto,Oslo university hospital,Univ Hlth Network, Lab Med Program, Toronto, ON, Canada.;Univ Toronto, Toronto, ON, Canada.;Univ Hosp Oslo, Dept Pathol, Oslo, Norway.
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- Juvonen, V (author)
- University of Turku,Univ Turku, Dept Clin Chem, Turku, Finland.;Univ Turku, Lab Div, Turku, Finland.;Turku Univ Hosp, Turku, Finland.
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- Osnes, L T N (author)
- Oslo university hospital,Herlev Hospital,Oslo Univ Hosp, Dept Immunol, Oslo, Norway.,Herlev Univ Hosp, Dept Hematol, Herlev, Denmark.
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Vålerhaugen, H (author)
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- Hultdin, Magnus (author)
- Umeå universitet,Patologi
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- Matuzeviciene, R (author)
- Vilnius University,Vilnius Univ, Inst Biomed Sci, Fac Med, Dept Physiol Biochem Microbiol & Lab Med, Vilnius, Lithuania.;Vilnius Univ Hosp, Santaros Klin, Ctr Lab Med, Vilnius, Lithuania.
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Stoskus, M (author)
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- Ehinger, M. (author)
- Lund University,Lunds universitet,Uppsala University,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Dept Clin Genet & Pathol, Lund, Sweden.;Lund Univ, Dept Clin Sci Oncol & Pathol, Lund, Sweden.
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- Lilleorg, A (author)
- North Estonia Medical Centre,North Estonia Med Ctr, Dept Clin Immunol, Tallinn, Estonia.
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Ehinger, M (author)
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- Norén-Nyström, Ulrika (author)
- Umeå University,Umeå universitet,Pediatrik,Umeå Univ, Dept Clin Sci, Pediat, Umeå, Sweden.
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Toft, N (author)
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- Taskinen, M (author)
- Helsinki University Central Hospital,Helsinki Univ Hosp, Div Pediat Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland.
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- Jónsson, O G (author)
- National University Hospital of Iceland,Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland.
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- Pruunsild, K (author)
- Tallinn Children's Hospital,Tallinn Childrens Hosp, Tallinn, Estonia.
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- Vaitkeviciene, G (author)
- Vilnius University,Vilnius Univ Hosp, Santariskiu Klin, Childrens Hosp, Vilnius, Lithuania.
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- Vettenranta, K (author)
- University of Helsinki,Univ Helsinki, Helsinki, Finland.;Univ Helsinki, Childrens Hosp, Helsinki, Finland.
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- Lund, B (author)
- St. Olav’s University Hospital,St Olavs Univ Hosp, Dept Pediat, Trondheim, Norway.;NTNU, Dept Clin & Mol Med, Trondheim, Norway.
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- Abrahamsson, Jonas, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.
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- Porwit, A. (author)
- Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Fac Med, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.
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- Schmiegelow, K (author)
- Copenhagen University Hospital,Copenhagen Univ Hosp, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Inst Clin Med, Fac Med, Copenhagen, Denmark.
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Marquart, H V (author)
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- Marincevic, Millaray, 1983- (author)
- Uppsala universitet,Klinisk och experimentell patologi
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(creator_code:org_t)
- 2020-12-14
- 2021
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 35, s. 1894-1906
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Abstract
Subject headings
Close
- PCR of TCR/Ig gene rearrangements is considered the method of choice for minimal residual disease (MRD) quantification in BCP-ALL, but flow cytometry analysis of leukemia-associated immunophenotypes (FCM-MRD) is faster and biologically more informative. FCM-MRD performed in 18 laboratories across seven countries was used for risk stratification of 1487 patients with BCP-ALL enrolled in the NOPHO ALL2008 protocol. When no informative FCM-marker was available, risk stratification was based on real-time quantitative PCR. An informative FCM-marker was found in 96.2% and only two patients (0.14%) had non-informative FCM and non-informative PCR-markers. The overall 5-year event-free survival was 86.1% with a cumulative incidence of relapse (CIR5y) of 9.5%. FCM-MRD levels on days 15 (HzR 4.0, p<0.0001), 29 (HzR 2.7, p<0.0001), and 79 (HzR 3.5, p<0.0001) associated with hazard of relapse adjusted for age, cytogenetics, and WBC. The early (day 15) response associated with CIR5y adjusted for day 29 FCM-MRD, with higher levels in adults (median 2.4×10-2 versus 5.2×10-3, p<0.0001). Undetectable FCM- and/or PCR-MRD on day 29 identified patients with a very good outcome (CIR5y=3.2%). For patients who did not undergo transplantation, day 79 FCM-MRD>10-4 associated with a CIR5y=22.1%. In conclusion, FCM-MRD performed in a multicenter setting is a clinically useful method for MRD-based treatment stratification in BCP-ALL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Leukemia
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To the university's database
- By the author/editor
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Modvig, S
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Hallböök, Helene
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Madsen, H O
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Siitonen, S
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Rosthøj, S
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Tierens, A
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show more...
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Juvonen, V
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Osnes, L T N
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Vålerhaugen, H
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Hultdin, Magnus
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Matuzeviciene, R
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Stoskus, M
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Ehinger, M.
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Lilleorg, A
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Ehinger, M
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Norén-Nyström, U ...
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Toft, N
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Taskinen, M
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Jónsson, O G
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Pruunsild, K
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Vaitkeviciene, G
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Vettenranta, K
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Lund, B
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Abrahamsson, Jon ...
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Porwit, A.
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Schmiegelow, K
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Marquart, H V
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Marincevic, Mill ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Leukemia
- By the university
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University of Gothenburg
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Umeå University
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Lund University
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Uppsala University