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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004101naa a2200589 4500
001oai:gup.ub.gu.se/300254
003SwePub
008240528s2020 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3002542 URI
0247 a https://doi.org/10.1210/clinem/dgaa5582 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Karlsson, Cecilia,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut
2451 0a Identification of Proteins Associated with the Early Restoration of Insulin Sensitivity After Biliopancreatic Diversion
264 c 2020-08-24
264 1b The Endocrine Society,c 2020
520 a Context: Insulin resistance (IR) is a risk factor for type 2 diabetes, diabetic kidney disease, cardiovascular disease and nonalcoholic steatohepatitis. Biliopancreatic diversion (BPD) is the most effective form of bariatric surgery for improving insulin sensitivity. Objective: To identify plasma proteins correlating with the early restoration of insulin sensitivity after BPD. Design: Prospective single-center study including 20 insulin-resistant men with morbid obesity scheduled for BPD. Patient characteristics and blood samples were repeatedly collected from baseline up to 4 weeks postsurgery. IR was assessed by homeostatic model assessment for insulin resistance (HOMA-IR), Matsuda Index, and by studying metabolic profiles during meal tolerance tests. Unbiased proteomic analysis was performed to identify plasma proteins altered by BPD. Detailed plasma profiles were made on a selected set of proteins by targeted multiple reaction monitoring mass spectrometry (MRM/MS). Changes in plasma proteome were evaluated in relation to metabolic and inflammatory changes. Results: BPD resulted in improved insulin sensitivity and reduced body weight. Proteomic analysis identified 29 proteins that changed following BPD. Changes in plasma levels of afamin, apolipoprotein A-IV (ApoA4), and apolipoprotein A-II (ApoA2) correlated significantly with changes in IR. Conclusion: Circulating levels of afamin, ApoA4, and ApoA2 were associated with and may contribute to the rapid improvement in insulin sensitivity after BPD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a afamin
653 a apolipoprotein A-II
653 a apolipoprotein A-IV
653 a biliopancreatic
653 a diversion
653 a insulin resistance
653 a proteomic analysis
653 a apolipoprotein-a-iv
653 a chronic kidney-disease
653 a bariatric surgery
653 a resistance
653 a polymorphism
653 a replication
653 a mild
653 a Endocrinology & Metabolism
7001 a Wallenius, K.4 aut
7001 a Walentinsson, A.4 aut
7001 a Greasley, P. J.4 aut
7001 a Miliotis, T.4 aut
7001 a Hammar, M.4 aut
7001 a Iaconelli, A.4 aut
7001 a Tapani, S.4 aut
7001 a Raffaelli, M.4 aut
7001 a Mingrone, G.4 aut
7001 a Carlsson, Björn,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xcarbj
7102 a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org
7730 t Journal of Clinical Endocrinology & Metabolismd : The Endocrine Societyg 105:11q 105:11x 0021-972Xx 1945-7197
8564 u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518464
8564 8u https://gup.ub.gu.se/publication/300254
8564 8u https://doi.org/10.1210/clinem/dgaa558

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