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High-resolution 3D ...
High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging
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Chen, J. Y. (author)
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Sivan, U. (author)
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Tan, S. L. (author)
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Lippo, L. (author)
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De Angelis, J. (author)
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Labella, R. (author)
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Singh, A. (author)
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Chatzis, A. (author)
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- Cheuk, Stanley, 1986 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Medhghalchi, M. (author)
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Gil, J. (author)
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Hollander, G. (author)
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Marsden, B. D. (author)
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Williams, R. (author)
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Ramasamy, S. K. (author)
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Kusumbe, A. P. (author)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2021
- 2021
- English.
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In: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 7:6
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https://advances.sci...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Blood vessels provide supportive microenvironments for maintaining tissue functions. Age-associated vascular changes and their relation to tissue aging and pathology are poorly understood. Here, we perform 3D imaging of young and aging vascular beds. Multiple organs in mice and humans demonstrate an age-dependent decline in vessel density and pericyte numbers, while highly remodeling tissues such as skin preserve the vasculature. Vascular attrition precedes the appearance of cellular hallmarks of aging such as senescence. Endothelial VEGFR2 loss-of-function mice demonstrate that vascular perturbations are sufficient to stimulate cellular changes coupled with aging. Age-associated tissue-specific molecular changes in the endothelium drive vascular loss and dictate pericyte to fibroblast differentiation. Lineage tracing of perivascular cells with inducible PDGERB and NG2 Cre mouse lines demonstrated that increased pericyte to fibroblast differentiation distinguishes injury-induced organ fibrosis and zymosan-induced arthritis. To spur further discoveries, we provide a freely available resource with 3D vascular and tissue maps.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chen, J. Y.
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Sivan, U.
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Tan, S. L.
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Lippo, L.
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De Angelis, J.
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Labella, R.
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show more...
-
Singh, A.
-
Chatzis, A.
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Cheuk, Stanley, ...
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Medhghalchi, M.
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Gil, J.
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Hollander, G.
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Marsden, B. D.
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Williams, R.
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Ramasamy, S. K.
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Kusumbe, A. P.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Science Advances
- By the university
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University of Gothenburg