Sökning: onr:"swepub:oai:gup.ub.gu.se/303566" > Plasma glial fibril...
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000 | 05037naa a2200505 4500 | |
001 | oai:gup.ub.gu.se/303566 | |
003 | SwePub | |
008 | 240910s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3035662 URI |
024 | 7 | a https://doi.org/10.1093/braincomms/fcaa1372 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Laverse, Etienne4 aut |
245 | 1 0 | a Plasma glial fibrillary acidic protein and neurofilament light chain, but not tau, are biomarkers of sports-related mild traumatic brain injury. |
264 | c 2020-09-07 | |
264 | 1 | b Oxford University Press (OUP),c 2020 |
520 | a Mild traumatic brain injury is a relatively common event in contact sports and there is increasing interest in the long-term neurocognitive effects. The diagnosis largely relies on symptom reporting and there is a need for objective tools to aid diagnosis and prognosis. There are recent reports that blood biomarkers could potentially help triage patients with suspected injury and normal CT findings. We have measured plasma concentrations of glial and neuronal proteins and explored their potential in the assessment of mild traumatic brain injury in contact sport. We recruited a prospective cohort of active male rugby players, who had pre-season baseline plasma sampling. From this prospective cohort, we recruited 25 players diagnosed with mild traumatic brain injury. We sampled post-match rugby players without head injuries as post-match controls. We measured plasma neurofilament light chain, tau and glial fibrillary acidic protein levels using ultrasensitive single molecule array technology. The data were analysed at the group and individual player level. Plasma glial fibrillary acidic protein concentration was significantly increased 1-h post-injury in mild traumatic brain injury cases compared to the non-injured group (P=0.017). Pairwise comparison also showed that glial fibrillary acidic protein levels were higher in players after a head injury in comparison to their pre-season levels at both 1-h and 3- to 10-day post-injury time points (P=0.039 and 0.040, respectively). There was also an increase in neurofilament light chain concentration in brain injury cases compared to the pre-season levels within the same individual at both time points (P=0.023 and 0.002, respectively). Tau was elevated in both the non-injured control group and the 1-h post-injury group compared to pre-season levels (P=0.007 and 0.015, respectively). Furthermore, receiver operating characteristic analysis showed that glial fibrillary acidic protein and neurofilament light chain can separate head injury cases from control players. The highest diagnostic power was detected when biomarkers were combined in differentiating 1-h post-match control players from 1-h post-head injury players (area under curve 0.90, 95% confidence interval 0.79-1.00, P<0.0002). The brain astrocytic marker glial fibrillary acidic protein is elevated in blood 1h after mild traumatic brain injury and in combination with neurofilament light chain displayed the potential as a reliable biomarker for brain injury evaluation. Plasma total tau is elevated following competitive rugby with and without a head injury, perhaps related to peripheral nerve trauma and therefore total tau does not appear to be suitable as a blood biomarker. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Guo, Tong4 aut |
700 | 1 | a Zimmerman, Karl4 aut |
700 | 1 | a Foiani, Martha S4 aut |
700 | 1 | a Velani, Bharat4 aut |
700 | 1 | a Morrow, Philip4 aut |
700 | 1 | a Adejuwon, Ademola4 aut |
700 | 1 | a Bamford, Richard4 aut |
700 | 1 | a Underwood, Natasha4 aut |
700 | 1 | a George, Jonathan4 aut |
700 | 1 | a Brooke, Daniel4 aut |
700 | 1 | a O'Brien, Karen4 aut |
700 | 1 | a Cross, Matthew J4 aut |
700 | 1 | a Kemp, Simon P T4 aut |
700 | 1 | a Heslegrave, Amanda J4 aut |
700 | 1 | a Hardy, John4 aut |
700 | 1 | a Sharp, David J4 aut |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Morris, Huw R4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Brain communicationsd : Oxford University Press (OUP)g 2:2q 2:2x 2632-1297 |
856 | 4 | u https://academic.oup.com/braincomms/advance-article-pdf/doi/10.1093/braincomms/fcaa137/33723033/fcaa137.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/303566 |
856 | 4 8 | u https://doi.org/10.1093/braincomms/fcaa137 |
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