onr:"swepub:oai:gup.ub.gu.se/307994"
Sökning: onr:"swepub:oai:gup.ub.gu.se/307994" > HLA-DRB1 and HLA-DQ...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07521naa a2201897 4500 | |
| 001 | oai:gup.ub.gu.se/307994 | |
| 003 | SwePub | |
| 008 | 240528s2021 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:147595556 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3079942 URI |
| 024 | 7 | a https://doi.org/10.1038/s41598-021-97140-72 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1475955562 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Le Clerc, S.4 aut |
| 245 | 1 0 | a HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders |
| 264 | c 2021-09-08 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 520 | a Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and reliable biomarkers allowing patients stratification are still needed. A GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region. To better understand the molecular mechanisms underlying this association, we have genetically imputed the classical alleles of the HLA region in the European patients of the ConLiGen cohort. We found our best signal for amino-acid variants belonging to the HLA-DRB1*11:01 classical allele, associated with a better response to Li (p < 1 x 10(-3); FDR < 0.09 in the recessive model). Alanine or Leucine at position 74 of the HLA-DRB1 heavy chain was associated with a good response while Arginine or Glutamic acid with a poor response. As these variants have been implicated in common inflammatory/autoimmune processes, our findings strongly suggest that HLA-mediated low inflammatory background may contribute to the efficient response to Li in BD patients, while an inflammatory status overriding Li anti-inflammatory properties would favor a weak response. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a comparative efficacy | |
| 653 | a class ii | |
| 653 | a hla | |
| 653 | a association | |
| 653 | a disease | |
| 653 | a risk | |
| 653 | a prophylaxis | |
| 653 | a prediction | |
| 653 | a mania | |
| 653 | a Science & Technology - Other Topics | |
| 700 | 1 | a Lombardi, L.u Karolinska Institutet4 aut |
| 700 | 1 | a Baune, B. T.4 aut |
| 700 | 1 | a Amare, A. T.4 aut |
| 700 | 1 | a Schubert, K. O.4 aut |
| 700 | 1 | a Hou, L. P.4 aut |
| 700 | 1 | a Clark, S. R.4 aut |
| 700 | 1 | a Papiol, S.4 aut |
| 700 | 1 | a Cearns, M.4 aut |
| 700 | 1 | a Heilbronner, U.4 aut |
| 700 | 1 | a Degenhardt, F.4 aut |
| 700 | 1 | a Tekola-Ayele, F.4 aut |
| 700 | 1 | a Hsu, Y. H.4 aut |
| 700 | 1 | a Shekhtman, T.4 aut |
| 700 | 1 | a Adli, M.4 aut |
| 700 | 1 | a Akula, N.4 aut |
| 700 | 1 | a Akiyama, K.4 aut |
| 700 | 1 | a Ardau, R.4 aut |
| 700 | 1 | a Arias, B.4 aut |
| 700 | 1 | a Aubry, J. M.4 aut |
| 700 | 1 | a Backlund, L.4 aut |
| 700 | 1 | a Bhattacharjee, A. K.4 aut |
| 700 | 1 | a Bellivier, F.4 aut |
| 700 | 1 | a Benabarre, A.4 aut |
| 700 | 1 | a Bengesser, S.4 aut |
| 700 | 1 | a Biernacka, J. M.4 aut |
| 700 | 1 | a Birner, A.4 aut |
| 700 | 1 | a Brichant-Petitjean, C.4 aut |
| 700 | 1 | a Cervantes, P.4 aut |
| 700 | 1 | a Chen, H. C.4 aut |
| 700 | 1 | a Chillotti, C.u Karolinska Institutet4 aut |
| 700 | 1 | a Cichon, S.4 aut |
| 700 | 1 | a Cruceanu, C.4 aut |
| 700 | 1 | a Czerski, P. M.4 aut |
| 700 | 1 | a Dalkner, N.4 aut |
| 700 | 1 | a Dayer, A.4 aut |
| 700 | 1 | a Del Zompo, M.4 aut |
| 700 | 1 | a DePaulo, J. R.4 aut |
| 700 | 1 | a Etain, B.4 aut |
| 700 | 1 | a Jamain, S.4 aut |
| 700 | 1 | a Falkai, P.4 aut |
| 700 | 1 | a Forstner, A. J.4 aut |
| 700 | 1 | a Frisen, L.4 aut |
| 700 | 1 | a Frye, M. A.4 aut |
| 700 | 1 | a Fullerton, J. M.4 aut |
| 700 | 1 | a Gard, S.4 aut |
| 700 | 1 | a Garnham, J. S.4 aut |
| 700 | 1 | a Goes, F. S.4 aut |
| 700 | 1 | a Grigoroiu-Serbanescu, M.4 aut |
| 700 | 1 | a Grof, P.4 aut |
| 700 | 1 | a Hashimoto, R.4 aut |
| 700 | 1 | a Hauser, J.4 aut |
| 700 | 1 | a Herms, S.4 aut |
| 700 | 1 | a Hofmann, P.4 aut |
| 700 | 1 | a Jimenez, E.4 aut |
| 700 | 1 | a Kahn, J. P.4 aut |
| 700 | 1 | a Kassem, L.4 aut |
| 700 | 1 | a Kuo, P. H.4 aut |
| 700 | 1 | a Kato, T.4 aut |
| 700 | 1 | a Kelsoe, J. R.4 aut |
| 700 | 1 | a Kittel-Schneider, S.4 aut |
| 700 | 1 | a Ferensztajn-Rochowiak, E.4 aut |
| 700 | 1 | a Konig, B.4 aut |
| 700 | 1 | a Kusumi, I.4 aut |
| 700 | 1 | a Laje, G.4 aut |
| 700 | 1 | a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xlandt |
| 700 | 1 | a Lavebratt, C.4 aut |
| 700 | 1 | a Leckband, S.4 aut |
| 700 | 1 | a Tortorella, A.4 aut |
| 700 | 1 | a Manchia, M.u Karolinska Institutet4 aut |
| 700 | 1 | a Martinsson, L.4 aut |
| 700 | 1 | a McCarthy, M. J.4 aut |
| 700 | 1 | a McElroy, S. L.4 aut |
| 700 | 1 | a Colom, F.4 aut |
| 700 | 1 | a Millischer, V.u Karolinska Institutet4 aut |
| 700 | 1 | a Mitjans, M.4 aut |
| 700 | 1 | a Mondimore, F. M.4 aut |
| 700 | 1 | a Monteleone, P.4 aut |
| 700 | 1 | a Nievergelt, C. M.4 aut |
| 700 | 1 | a Nothen, M. M.4 aut |
| 700 | 1 | a Novak, T.4 aut |
| 700 | 1 | a O'Donovan, C.4 aut |
| 700 | 1 | a Ozaki, N.4 aut |
| 700 | 1 | a Osby, U.4 aut |
| 700 | 1 | a Pfennig, A.4 aut |
| 700 | 1 | a Potash, J. B.4 aut |
| 700 | 1 | a Reif, A.4 aut |
| 700 | 1 | a Reininghaus, E.4 aut |
| 700 | 1 | a Rouleau, G. A.4 aut |
| 700 | 1 | a Rybakowski, J. K.4 aut |
| 700 | 1 | a Schalling, M.4 aut |
| 700 | 1 | a Schofeld, P. R.4 aut |
| 700 | 1 | a Schweizer, B. W.4 aut |
| 700 | 1 | a Severino, G.4 aut |
| 700 | 1 | a Shilling, P. D.4 aut |
| 700 | 1 | a Shimoda, K.4 aut |
| 700 | 1 | a Simhandl, C.4 aut |
| 700 | 1 | a Slaney, C. M.4 aut |
| 700 | 1 | a Pisanu, C.4 aut |
| 700 | 1 | a Squassina, A.4 aut |
| 700 | 1 | a Stamm, T.4 aut |
| 700 | 1 | a Stopkova, P.4 aut |
| 700 | 1 | a Maj, M.4 aut |
| 700 | 1 | a Turecki, G.4 aut |
| 700 | 1 | a Vieta, E.4 aut |
| 700 | 1 | a Veeh, J.4 aut |
| 700 | 1 | a Witt, S. H.4 aut |
| 700 | 1 | a Wright, A.4 aut |
| 700 | 1 | a Zandi, P. P.4 aut |
| 700 | 1 | a Mitchell, P. B.4 aut |
| 700 | 1 | a Bauer, M.4 aut |
| 700 | 1 | a Alda, M.4 aut |
| 700 | 1 | a Rietschel, M.4 aut |
| 700 | 1 | a McMahon, F. J.4 aut |
| 700 | 1 | a Schulze, T. G.4 aut |
| 700 | 1 | a Boukouaci, W.4 aut |
| 700 | 1 | a Richard, J. R.4 aut |
| 700 | 1 | a Le Corvoisier, P.4 aut |
| 700 | 1 | a Barrau, C.4 aut |
| 700 | 1 | a Zagury, J. F.4 aut |
| 700 | 1 | a Leboyer, M.4 aut |
| 700 | 1 | a Tamouza, R.4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi4 org |
| 773 | 0 | t Scientific Reportsd : Springer Science and Business Media LLCg 11:1q 11:1x 2045-2322 |
| 856 | 4 | u https://www.nature.com/articles/s41598-021-97140-7.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/307994 |
| 856 | 4 8 | u https://doi.org/10.1038/s41598-021-97140-7 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147595556 |
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Le Clerc, S.
- Lombardi, L.
- Baune, B. T.
- Amare, A. T.
- Schubert, K. O.
- Hou, L. P.
- visa fler...
- Clark, S. R.
- Papiol, S.
- Cearns, M.
- Heilbronner, U.
- Degenhardt, F.
- Tekola-Ayele, F.
- Hsu, Y. H.
- Shekhtman, T.
- Adli, M.
- Akula, N.
- Akiyama, K.
- Ardau, R.
- Arias, B.
- Aubry, J. M.
- Backlund, L.
- Bhattacharjee, A ...
- Bellivier, F.
- Benabarre, A.
- Bengesser, S.
- Biernacka, J. M.
- Birner, A.
- Brichant-Petitje ...
- Cervantes, P.
- Chen, H. C.
- Chillotti, C.
- Cichon, S.
- Cruceanu, C.
- Czerski, P. M.
- Dalkner, N.
- Dayer, A.
- Del Zompo, M.
- DePaulo, J. R.
- Etain, B.
- Jamain, S.
- Falkai, P.
- Forstner, A. J.
- Frisen, L.
- Frye, M. A.
- Fullerton, J. M.
- Gard, S.
- Garnham, J. S.
- Goes, F. S.
- Grigoroiu-Serban ...
- Grof, P.
- Hashimoto, R.
- Hauser, J.
- Herms, S.
- Hofmann, P.
- Jimenez, E.
- Kahn, J. P.
- Kassem, L.
- Kuo, P. H.
- Kato, T.
- Kelsoe, J. R.
- Kittel-Schneider ...
- Ferensztajn-Roch ...
- Konig, B.
- Kusumi, I.
- Laje, G.
- Landén, Mikael, ...
- Lavebratt, C.
- Leckband, S.
- Tortorella, A.
- Manchia, M.
- Martinsson, L.
- McCarthy, M. J.
- McElroy, S. L.
- Colom, F.
- Millischer, V.
- Mitjans, M.
- Mondimore, F. M.
- Monteleone, P.
- Nievergelt, C. M ...
- Nothen, M. M.
- Novak, T.
- O'Donovan, C.
- Ozaki, N.
- Osby, U.
- Pfennig, A.
- Potash, J. B.
- Reif, A.
- Reininghaus, E.
- Rouleau, G. A.
- Rybakowski, J. K ...
- Schalling, M.
- Schofeld, P. R.
- Schweizer, B. W.
- Severino, G.
- Shilling, P. D.
- Shimoda, K.
- Simhandl, C.
- Slaney, C. M.
- Pisanu, C.
- Squassina, A.
- Stamm, T.
- Stopkova, P.
- Maj, M.
- Turecki, G.
- Vieta, E.
- Veeh, J.
- Witt, S. H.
- Wright, A.
- Zandi, P. P.
- Mitchell, P. B.
- Bauer, M.
- Alda, M.
- Rietschel, M.
- McMahon, F. J.
- Schulze, T. G.
- Boukouaci, W.
- Richard, J. R.
- Le Corvoisier, P ...
- Barrau, C.
- Zagury, J. F.
- Leboyer, M.
- Tamouza, R.
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Neurologi
- Artiklar i publikationen
- Scientific Repor ...
- Av lärosätet
- Göteborgs universitet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
