Sökning: onr:"swepub:oai:gup.ub.gu.se/309037" > Four distinct traje...
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001 | oai:gup.ub.gu.se/309037 | |
003 | SwePub | |
008 | 240528s2021 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:a3e8b18c-1343-4744-b3ff-ca3b1347aeb6 | |
024 | 7 | a https://gup.ub.gu.se/publication/3090372 URI |
024 | 7 | a https://doi.org/10.1038/s41591-021-01309-62 DOI |
024 | 7 | a https://lup.lub.lu.se/record/a3e8b18c-1343-4744-b3ff-ca3b1347aeb62 URI |
040 | a (SwePub)gud (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Vogel, Jacob W.u McGill University4 aut0 (Swepub:lu)ja8870vo |
245 | 1 0 | a Four distinct trajectories of tau deposition identified in Alzheimer’s disease |
264 | c 2021-04-29 | |
264 | 1 | b Springer Science and Business Media LLC,c 2021 |
520 | a Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%. We replicated previously described limbic-predominant and medial temporal lobe-sparing patterns, while also discovering posterior and lateral temporal patterns resembling atypical clinical variants of AD. These ‘subtypes’ were stable during longitudinal follow-up and were replicated in a separate sample using a different radiotracer. The subtypes presented with distinct demographic and cognitive profiles and differing longitudinal outcomes. Additionally, network diffusion models implied that pathology originates and spreads through distinct corticolimbic networks in the different subtypes. Together, our results suggest that variation in tau pathology is common and systematic, perhaps warranting a re-examination of the notion of ‘typical AD’ and a revisiting of tau pathological staging. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
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700 | 1 | a Oxtoby, N. P.u University College London4 aut |
700 | 1 | a Smith, Rubenu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-rsm |
700 | 1 | a Ossenkoppele, Riku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Academic Medical Center of University of Amsterdam (AMC),Vrije Universiteit Amsterdam4 aut0 (Swepub:lu)ri1513os |
700 | 1 | a Strandberg, Olof T.u Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)teor-osn |
700 | 1 | a La Joie, R.u University of California, San Francisco4 aut |
700 | 1 | a Aksman, L. M.u University College London4 aut |
700 | 1 | a Grothe, Michel J.,d 1981u University of Gothenburg,Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine4 aut0 (Swepub:gu)xgromi |
700 | 1 | a Iturria-Medina, Y.u McGill University4 aut |
700 | 1 | a Weiner, M.4 aut |
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700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn |
710 | 2 | a McGill Universityb King's College London4 org |
773 | 0 | t Nature Medicined : Springer Science and Business Media LLCg 27:5, s. 871-881q 27:5<871-881x 1078-8956x 1546-170X |
856 | 4 | u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686688 |
856 | 4 | u http://dx.doi.org/10.1038/s41591-021-01309-6y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/309037 |
856 | 4 8 | u https://doi.org/10.1038/s41591-021-01309-6 |
856 | 4 8 | u https://lup.lub.lu.se/record/a3e8b18c-1343-4744-b3ff-ca3b1347aeb6 |
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