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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04073naa a2200577 4500 | |
| 001 | oai:gup.ub.gu.se/318119 | |
| 003 | SwePub | |
| 008 | 240910s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3181192 URI |
| 024 | 7 | a https://doi.org/10.1016/j.ekir.2022.02.0012 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Winitzki, D.4 aut |
| 245 | 1 0 | a Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort |
| 264 | 1 | b Elsevier BV,c 2022 |
| 520 | a Introduction: Prospective data on impact of educational attainment on prognosis in patients with chronic kidney disease (CKD) are scarce. We investigated the association between educational attainment and all-cause mortality, major adverse cardiovascular (CV) events (MACEs), kidney failure requiring dialysis, and CKD etiology. Methods: Participants (N = 5095, aged 18–74 years) of the ongoing multicenter German Chronic Kidney Disease (GCKD) cohort, enrolled on the basis of an estimated glomerular filtration rate (eGFR) of 30 to 60 ml/min (stages G3, A1–A3) or overt proteinuria (stages G1–G2, A3), were divided into 3 categories according to their educational attainment and were followed for 6.5 years. Results: Participants with low educational attainment (vs. high) had a higher risk for mortality (hazard ratio [HR] 1.48, 95% CI: 1.16–1.90), MACE (HR 1.37, 95% CI: 1.02–1.83), and kidney failure (HR 1.54, 95% CI: 1.15–2.05). Mediators between low educational attainment and mortality were smoking, CV disease (CVD) at baseline, low income, higher body mass index, and higher serum levels of CRP, high-density lipoprotein cholesterol, uric acid, NGAL, BAP, NT-proBNP, OPN, H-FABP, and urea. Low educational attainment was positively associated with diabetic nephropathy (odds ratio [OR] 1.65, 95% CI: 1.36–2.0) and CKD subsequent to acute kidney injury (OR 1.56, 95% CI: 1.03–2.35), but negatively associated with IgA nephropathy (OR 0.68, 95% CI: 0.52–0.90). Conclusion: Low educational attainment is associated with adverse outcomes and CKD etiology. Lifestyle habits and biomarkers mediate associations between low educational attainment and mortality. Recognition of the role of educational attainment and the associated health-relevant risk factors is important to optimize the care of patients with CKD and improve prognosis. © 2022 International Society of Nephrology | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
| 653 | a biomarker | |
| 653 | a CASMIN | |
| 653 | a chronic kidney disease | |
| 653 | a CKD | |
| 653 | a educational attainment | |
| 653 | a socioeconomic status | |
| 700 | 1 | a Zacharias, H. U.4 aut |
| 700 | 1 | a Nadal, J.4 aut |
| 700 | 1 | a Baid-Agrawal, Seema,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xbaise |
| 700 | 1 | a Schaeffner, E.4 aut |
| 700 | 1 | a Schmid, M.4 aut |
| 700 | 1 | a Busch, M.4 aut |
| 700 | 1 | a Bergmann, M. M.4 aut |
| 700 | 1 | a Schultheiss, U.4 aut |
| 700 | 1 | a Kotsis, F.4 aut |
| 700 | 1 | a Stockmann, H.4 aut |
| 700 | 1 | a Meiselbach, H.4 aut |
| 700 | 1 | a Wolf, G.4 aut |
| 700 | 1 | a Krane, V.4 aut |
| 700 | 1 | a Sommerer, C.4 aut |
| 700 | 1 | a Eckardt, K. U.4 aut |
| 700 | 1 | a Schneider, M. P.4 aut |
| 700 | 1 | a Schlieper, G.4 aut |
| 700 | 1 | a Floege, J.4 aut |
| 700 | 1 | a Saritas, T.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin4 org |
| 773 | 0 | t Kidney International Reportsd : Elsevier BVg 7:5, s. 1004-1015q 7:5<1004-1015x 2468-0249 |
| 856 | 4 | u http://www.kireports.org/article/S2468024922011378/pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/318119 |
| 856 | 4 8 | u https://doi.org/10.1016/j.ekir.2022.02.001 |
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