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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008674naa a2200733 4500
001oai:gup.ub.gu.se/318613
003SwePub
008240528s2022 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-483882
009oai:lup.lub.lu.se:6578fb3c-e71f-4d4b-ae6e-4d28314eebe8
0247 a https://gup.ub.gu.se/publication/3186132 URI
0247 a https://doi.org/10.26508/lsa.2022013762 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4838822 URI
0247 a https://lup.lub.lu.se/record/6578fb3c-e71f-4d4b-ae6e-4d28314eebe82 URI
040 a (SwePub)gud (SwePub)uud (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Asplund, Olofu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)med-oap
2451 0a Islet Gene View-a tool to facilitate islet research
264 c 2022-08-10
264 1b Life Science Alliance, LLC,c 2022
520 a Characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes (T2D) are vital in understanding islet function and T2D pathogenesis. We leveraged RNA sequencing and genome-wide genotyping in islets from 188 donors to create the Islet Gene View (IGW) platform to make this information easily accessible to the scientific community. Expression data were related to islet phenotypes, diabetes status, other islet-expressed genes, islet hormone-encoding genes and for expression in insulin target tissues. The IGW web application produces output graphs for a particular gene of interest. In IGW, 284 differentially expressed genes (DEGs) were identified in T2D donor islets compared with controls. Forty percent of DEGs showed cell-type enrichment and a large proportion significantly co-expressed with islet hormone-encoding genes; glucagon (GCG, 56%), amylin (IAPP, 52%), insulin (INS, 44%), and somatostatin (SST, 24%). Inhibition of two DEGs, UNC5D and SERPINE2, impaired glucose-stimulated insulin secretion and impacted cell survival in a human beta-cell model. The exploratory use of IGW could help designing more comprehensive functional follow-up studies and serve to identify therapeutic targets in T2D.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a genome-wide association
653 a human pancreatic-islets
653 a insulin-secretion
653 a expression
653 a transcription
653 a variants
653 a Life Sciences & Biomedicine - Other Topics
7001 a Storm, Petteru Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Developmental and Regenerative Neurobiology,Lund University Research Groups,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-psm
7001 a Chandra, V.u Univ Helsinki, Fac Med, Stem Cells & Metab Res Program, Helsinki, Finland.,University of Helsinki4 aut
7001 a Hatem, Gadu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)ga5503ha
7001 a Ottosson-Laakso, Emiliau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)med-eo_
7001 a Mansour-Aly, Dinau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)di3053ma
7001 a Krus, Ulrikau Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,CRC, Clinical Research Centre,Medicinska fakulteten,Lund University Bioimaging Center,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,CRC, Clinical Research Centre,Faculty of Medicine4 aut0 (Swepub:lu)medk-ufr
7001 a Ibrahim, H.u Univ Helsinki, Fac Med, Stem Cells & Metab Res Program, Helsinki, Finland.,University of Helsinki4 aut
7001 a Ahlqvist, Emmau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)infl-eah
7001 a Tuomi, Tiinamaijau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Helsinki University Central Hospital,University of Helsinki4 aut0 (Swepub:lu)ti8736tu
7001 a Renström, Eriku Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-ere
7001 a Korsgren, Olleu Uppsala University,Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Institutionen för immunologi, genetik och patologi,, Sweden.;Univ Gothenburg, Inst Biomed, Dept Clin Chem & Transfus Med, Gothenburg, Sweden.4 aut0 (Swepub:uu)ollekors
7001 a Wierup, Nilsu Lund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-nwi
7001 a Ibberson, M.u SIB Swiss Inst Bioinformat, Vital IT Grp, Lausanne, Switzerland.,Swiss Institute for Bioinformatics (SIB)4 aut
7001 a Solimena, M.u Tech Univ Dresden, Paul Langerhans Inst Dresden, Munich Univ Hosp Carl Gustav Carus, Helmholtz Ctr, Dresden, Germany.;Tech Univ Dresden, Fac Med, Dresden, Germany.;German Ctr Diabet Res DZD, Munich, Germany.;Max Planck Inst Mol Cell Biol & Genet, MPI CBG, Dresden, Germany.,German Center for Diabetes Research4 aut
7001 a Marchetti, P.u Univ Pisa, Cisanello Univ Hosp, Dept Clin & Expt Med, Pisa, Italy.,University Hospital of Pisa4 aut
7001 a Wollheim, Claesu Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,University of Geneva4 aut0 (Swepub:lu)med-cwe
7001 a Artner, Isabellau Lund University,Lunds universitet,Endokrin Celldifferentiering,Forskargrupper vid Lunds universitet,Endocrine Cell Differentiation and Function,Lund University Research Groups4 aut0 (Swepub:lu)med-iba
7001 a Mulder, Hindriku Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups4 aut0 (Swepub:lu)medk-hmu
7001 a Hansson, Olau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)medk-oha
7001 a Otonkoski, T.u Univ Helsinki, Fac Med, Stem Cells & Metab Res Program, Helsinki, Finland.;Helsinki Univ Hosp, Childrens Hosp, Helsinki, Finland.,University of Helsinki4 aut
7001 a Groop, Leifu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)endo-lgr
7001 a Prasad, Rashmi Bu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)med-rpa
7102 a Translationell muskelforskningb Forskargrupper vid Lunds universitet4 org
7730 t Life Science Allianced : Life Science Alliance, LLCg 5:12q 5:12x 2575-1077
8564 u https://doi.org/10.26508/lsa.202201376y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1693072/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.26508/lsa.202201376x freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/318613
8564 8u https://doi.org/10.26508/lsa.202201376
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-483882
8564 8u https://lup.lub.lu.se/record/6578fb3c-e71f-4d4b-ae6e-4d28314eebe8

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