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Assessment of the m...
Assessment of the management of carcinomatous meningitis from breast cancer globally: a study by the Breast International Group Brain Metastasis Task Force
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Razis, E. (author)
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Escudero, M. J. (author)
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Palmieri, C. (author)
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Mueller, V. (author)
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Bartsch, R. (author)
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Rossi, G. (author)
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Gampenrieder, S. P. (author)
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Kolberg, H. C. (author)
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Zdenkowski, N. (author)
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Pavic, M. (author)
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Connolly, R. M. (author)
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Rosset, L. (author)
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Arcuri, J. (author)
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Tesch, H. (author)
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Vallejos, C. (author)
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Retamales, J. (author)
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Musolino, A. (author)
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Del Mastro, L. (author)
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Christodoulou, C. (author)
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Aebi, S. (author)
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Paluch-Shimon, S. (author)
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Gupta, S. (author)
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Ohno, S. (author)
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Macpherson, I. (author)
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- Ekholm, Maria (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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Zaman, K. (author)
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Vidal, M. (author)
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Chakiba, C. (author)
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Fumagalli, D. (author)
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Thulin, A. (author)
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Witzel, I. (author)
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Kotecki, N. (author)
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Gil-Gil, M. (author)
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Linderholm, B. (author)
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: ESMO Open. - : Elsevier BV. - 2059-7029. ; 7:3
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background: Carcinomatous meningitis (CM) is a severe complication of breast cancer. The Breast International Group (BIG) carried out a survey to describe the approach to CM internationally. Patients and methods: A questionnaire on the management of CM was developed by the Brain Metastases Task Force of BIG and distributed to its groups, requesting one answer per group site. Results: A total of 241 sites responded, 119 from Europe, 9 from North America, 39 from Central/South America, 58 from Asia, and 16 in Australia/New Zealand, with 24.5% being general hospitals with oncology units, 44.4% university hospitals, 22.4% oncology centers, and 8.7% private hospitals. About 56.0% of sites reported seeing <5 cases annually with 60.6% reporting no increase in the number of cases of CM recently. Nearly 63.1% of sites investigate for CM when a patient has symptoms or radiological evidence, while 33.2% investigate only for symptoms. For diagnosis, 71.8% of sites required a positive cerebrospinal fluid cytology, while magnetic resonance imaging findings were sufficient in 23.7% of sites. Roughly 97.1% of sites treat CM and 51.9% also refer patients to palliative care. Intrathecal therapy is used in 41.9% of sites, mainly with methotrexate (74.3%). As many as 20 centers have a national registry for patients with breast cancer with central nervous system metastases and of those 5 have one for CM. Most (90.9%) centers would be interested in participating in a registry as well as in studies for CM, the latter preferably (62.1%) breast cancer subtype specific. Conclusions: This is the first study to map out the approach to CM from breast cancer globally. Although guidelines with level 1 evidence are lacking, there is a high degree of homogeneity in the approach to CM globally and great interest for conducting studies in this area.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- breast cancer
- carcinomatous meningitis
Publication and Content Type
- ref (subject category)
- art (subject category)
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ESMO Open
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To the university's database
- By the author/editor
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Razis, E.
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Escudero, M. J.
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Palmieri, C.
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Mueller, V.
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Bartsch, R.
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Rossi, G.
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show more...
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Gampenrieder, S. ...
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Kolberg, H. C.
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Zdenkowski, N.
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Pavic, M.
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Connolly, R. M.
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Rosset, L.
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Arcuri, J.
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Tesch, H.
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Vallejos, C.
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Retamales, J.
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Musolino, A.
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Del Mastro, L.
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Christodoulou, C ...
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Aebi, S.
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Paluch-Shimon, S ...
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Gupta, S.
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Ohno, S.
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Macpherson, I.
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Ekholm, Maria
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Zaman, K.
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Vidal, M.
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Chakiba, C.
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Fumagalli, D.
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Thulin, A.
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Witzel, I.
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Kotecki, N.
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Gil-Gil, M.
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Linderholm, B.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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ESMO Open
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University of Gothenburg