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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06310naa a2200781 4500 | |
| 001 | oai:gup.ub.gu.se/326797 | |
| 003 | SwePub | |
| 008 | 240528s2023 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:c7695777-1be1-49e3-adbb-da4c525da856 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3267972 URI |
| 024 | 7 | a https://doi.org/10.1002/art.423932 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/c7695777-1be1-49e3-adbb-da4c525da8562 URI |
| 040 | a (SwePub)gud (SwePub)lu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Sumpter, N. A.u University of Alabama,University of Nottingham4 aut |
| 245 | 1 0 | a Association of Gout Polygenic Risk Score With Age at Disease Onset and Tophaceous Disease in European and Polynesian Men With Gout |
| 264 | c 2023-03-25 | |
| 264 | 1 | b Wiley,c 2023 |
| 520 | a Objective. To determine whether a gout polygenic risk score (PRS) is associated with age at gout onset and tophaceous disease in European, East Polynesian, and West Polynesian men and women with gout. Methods. A 19-variant gout PRS was produced in 7 European gout cohorts (N = 4,016), 2 East Polynesian gout cohorts (N = 682), and 1 West Polynesian gout cohort (N = 490). Sex-stratified regression models were used to estimate the relationship between the PRS and age at gout onset and tophaceous disease. Results. The PRS was associated with earlier age at gout onset in men (beta = -3.61 in years per unit PRS [95% confidence interval (95% CI) -4.32, -2.90] in European men; beta = -6.35 [95% CI -8.91, -3.80] in East Polynesian men; beta = -3.51 [95% CI -5.46, -1.57] in West Polynesian men) but not in women (beta = 0.07 [95% CI -2.32, 2.45] in European women; beta = 0.20 [95% CI -7.21, 7.62] in East Polynesian women; beta -3.33 [95% CI -9.28, 2.62] in West Polynesian women). The PRS showed a positive association with tophaceous disease in men (odds ratio [OR] for the association 1.15 [95% CI 1.00, 1.31] in European men; OR 2.60 [95% CI 1.66, 4.06] in East Polynesian men; OR 1.53 [95% CI 1.07, 2.19] in West Polynesian men) but not in women (OR for the association 0.68 [95% CI 0.42, 1.10] in European women; OR 1.45 [95% CI 0.39, 5.36] in East Polynesian women). The PRS association with age at gout onset was robust to the removal of ABCG2 variants from the PRS in European and East Polynesian men (beta = -2.42 [95% CI -3.37, -1.46] and beta = -6.80 [95% CI -10.06, -3.55], respectively) but not in West Polynesian men (beta = -1.79 [95% CI -4.74, 1.16]). Conclusion. Genetic risk variants for gout also harbor risk for earlier age at gout onset and tophaceous disease in European and Polynesian men. Our findings suggest that earlier gout onset involves the accumulation of gout risk alleles in men but perhaps not in women, and that this genetic risk is shared across multiple ancestral groups. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
| 700 | 1 | a Takei, R.4 aut |
| 700 | 1 | a Cadzow, M.u University of Otago4 aut |
| 700 | 1 | a Topless, R. K. G.u University of Otago4 aut |
| 700 | 1 | a Phipps-Green, A. J.u University of Otago4 aut |
| 700 | 1 | a Murphy, R.4 aut |
| 700 | 1 | a de Zoysa, J.4 aut |
| 700 | 1 | a Watson, H.4 aut |
| 700 | 1 | a Qasim, M.4 aut |
| 700 | 1 | a Lupi, A. S.u Michigan State University,Lausanne University Hospital4 aut |
| 700 | 1 | a Abhishek, A.u University of Medicine and Pharmacy, Cluj-Napoca4 aut |
| 700 | 1 | a Andres, M.u Miguel Hernández University of Elche4 aut |
| 700 | 1 | a Crisan, T. O.u University of Medicine and Pharmacy, Cluj-Napoca4 aut |
| 700 | 1 | a Doherty, M.u University of Nottingham4 aut |
| 700 | 1 | a Jacobsson, Lennart T. H.,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy4 aut0 (Swepub:lu)orto-lja |
| 700 | 1 | a Janssen, M.u Viecuri Medical Centre Of Northern Limburg,University of Otago4 aut |
| 700 | 1 | a Jansen, T. L.u Viecuri Medical Centre Of Northern Limburg4 aut |
| 700 | 1 | a Joosten, L. A. B.4 aut |
| 700 | 1 | a Kapetanovic, Melihau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)reum-mcr |
| 700 | 1 | a Liote, F.4 aut |
| 700 | 1 | a Matsuo, H.u National Defense Medical College4 aut |
| 700 | 1 | a McCarthy, G. M.u Mater Misericordiae University Hospital4 aut |
| 700 | 1 | a Perez-Ruiz, F.u Biocruces Bizkaia Health Research Institute4 aut |
| 700 | 1 | a Riches, P.u University of Edinburgh4 aut |
| 700 | 1 | a Richette, P.u Université Paris Cité4 aut |
| 700 | 1 | a Roddy, E.u Keele University4 aut |
| 700 | 1 | a Stiburkova, B.u General University Hospital in Prague4 aut |
| 700 | 1 | a So, A.4 aut |
| 700 | 1 | a Tausche, A. K.u University Clinic Carl Gustav Carus at the TU Dresden4 aut |
| 700 | 1 | a Torres, R. J.u University Hospital La Paz4 aut |
| 700 | 1 | a Uhlig, T.u Diakonhjemmet Hospital4 aut |
| 700 | 1 | a Major, T. J.4 aut |
| 700 | 1 | a Stamp, L. K.4 aut |
| 700 | 1 | a Dalbeth, N.4 aut |
| 700 | 1 | a Choi, H. K.u Massachusetts General Hospital4 aut |
| 700 | 1 | a Vazquez, A. I.u Michigan State University4 aut |
| 700 | 1 | a Leask, M. P.4 aut |
| 700 | 1 | a Reynolds, R. J.4 aut |
| 700 | 1 | a Merriman, T. R.u University of Alabama4 aut |
| 710 | 2 | a University of Alabamab University of Nottingham4 org |
| 773 | 0 | t Arthritis & Rheumatologyd : Wileyg 75:5, s. 816-825q 75:5<816-825x 2326-5191x 2326-5205 |
| 856 | 4 | u http://dx.doi.org/10.1002/art.42393y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/326797 |
| 856 | 4 8 | u https://doi.org/10.1002/art.42393 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/c7695777-1be1-49e3-adbb-da4c525da856 |
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