Neurodevelopmental and other psychiatric disorders in 22q11.2 deletion syndrome from childhood to adult age: Prospective longitudinal study of 100 individuals

Wallin, Lena (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology

Gillberg, Christopher, 1950 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Gillbergcentrum,Institute of Neuroscience and Physiology,Gillberg Neuropsychiatry Centre

Fernell, Elisabeth, 1948 (author): Gothenburg University,Göteborgs universitet,Gillbergcentrum,Institutionen för neurovetenskap och fysiologi,Gillberg Neuropsychiatry Centre,Institute of Neuroscience and Physiology

Gillberg, I Carina, 1949 (author): Gothenburg University,Göteborgs universitet,Gillbergcentrum,Institutionen för neurovetenskap och fysiologi,Gillberg Neuropsychiatry Centre,Institute of Neuroscience and Physiology

Billstedt, Eva, 1961 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Gillbergcentrum,Institute of Neuroscience and Physiology,Gillberg Neuropsychiatry Centre

(creator_code:org_t)

2023
2023
English.
In: American Journal of Medical Genetics Part C-Seminars in Medical Genetics. - 1552-4868. ; 193:2, s. 172-182

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

The 22q11.2 deletion syndrome (22q11.2DS), affects physical as well as cognitive and emotional functioning with increased risk for psychiatric and behavioral problems. This longitudinal study of 79 individuals (18-50 years) with 22q11.2DS investigated neurodevelopmental (NDD) and psychiatric disorders in adulthood, evaluated the stability of childhood diagnoses over time, and examined associations between clinical characteristics in childhood/adolescence and diagnostic outcome in adult age. Examination using validated instruments for cognitive, psychiatric, and global functional problems in the context of an in-depth clinical evaluation found adult age stability of NDD diagnoses made in childhood, however, rates increased at follow-up. Rates of anxiety, mood, and psychotic disorders were high, with a majority meeting diagnostic criteria for one or more psychiatric disorder. The rate of psychotic disorders was much lower compared to many other studies. Variability in functioning at follow-up was primarily associated with intellectual ability at T1. The findings obtained highlight the increased risk of NDD and psychiatric problems and of cognitive impairment and reduced levels of global functioning over time. Results emphasize the importance of clinical follow-up to enable appropriate support for the promotion of optimal health along with a need for future research on effective interventions and treatment strategies.

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)

By the author/editor: Wallin, Lena; Gillberg, Christ ...; Fernell, Elisabe ...; Gillberg, I Cari ...; Billstedt, Eva, ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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