Sökning: onr:"swepub:oai:gup.ub.gu.se/327604" > Antieosinophil Anti...
Fältnamn | Indikatorer | Metadata |
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000 | 05201naa a2200445 4500 | |
001 | oai:gup.ub.gu.se/327604 | |
003 | SwePub | |
008 | 240528s2023 | |||||||||||000 ||eng| | |
009 | oai:research.chalmers.se:981acd86-57c8-4cf6-8009-4284a1f2fc45 | |
024 | 7 | a https://gup.ub.gu.se/publication/3276042 URI |
024 | 7 | a https://doi.org/10.1155/2023/59802872 DOI |
024 | 7 | a https://research.chalmers.se/publication/5358042 URI |
040 | a (SwePub)gud (SwePub)cth | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Dieckmann, Regisu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg4 aut |
245 | 1 0 | a Antieosinophil Antibodies Alone or in Combination with Antineutrophil Cytoplasmic Antibodies (ANCA) Detected in Different Autoimmune Conditions |
264 | 1 | c 2023 |
520 | a Circulating antieosinophil antibodies (AEOSA) have been associated with various autoimmune conditions affecting the liver, kidneys, lungs, and joints but are not part of routine clinical diagnostics. While analyzing human sera for antineutrophil cytoplasmic antibodies (ANCA) by indirect immunofluorescence (IIF) on granulocytes, 0.8% of analyzed samples were found to be reactive with eosinophils. Our aim was to determine the diagnostic relevance and antigenic specificity of AEOSA. AEOSA were seen either in combination with an myeloperoxidase (MPO)-positive p-ANCA (44%; AEOSA+/ANCA+) or on their own (56%; AEOSA+/ANCA-). AEOSA/ANCA positivity was seen in patients with thyroid disease (44%) or vasculitis (31%), while AEOSA+/ANCA- pattern was more common in patients with autoimmune disorders of the gastrointestinal tract and/or liver. Eosinophil peroxidase (EPX) was the main target recognized in 66% of the AEOSA+ sera by enzyme-linked immunosorbent assay (ELISA). Eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN) were also identified as target antigens but less frequently and only in combination with EPX. In conclusion, we confirmed that EPX is a major target of AEOSA, illustrating the high antigenic potential of EPX. Our results also demonstrate the presence of concomitant AEOSA/ANCA positivity in a defined patient group. Further research should aim to elucidate the association of AEOSA with autoimmunity. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
653 | a eosinophil cationic protein | |
653 | a vasculitis | |
653 | a Immunology | |
700 | 1 | a Pullerits, Rille,d 1969u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,University of Gothenburg4 aut0 (Swepub:gu)xpulri |
700 | 1 | a Bylund, Johan,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,University of Gothenburg4 aut0 (Swepub:gu)xbyljo |
700 | 1 | a Karlsson-Bengtsson, Annau Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg4 aut0 (Swepub:cth)ankarls |
700 | 1 | a Herlitz, Hans,d 1946u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg4 aut0 (Swepub:gu)xherha |
700 | 1 | a Wennerås, Christine,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital4 aut0 (Swepub:gu)xwennc |
700 | 1 | a Thulin, Pontusu Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning4 org |
773 | 0 | t Journal of Immunology Researchg 2023q 2023x 2314-8861x 2314-7156 |
856 | 4 | u https://research.chalmers.se/publication/535804/file/535804_Fulltext.pdfx primaryx freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/327604 |
856 | 4 8 | u https://doi.org/10.1155/2023/5980287 |
856 | 4 8 | u https://research.chalmers.se/publication/535804 |
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