Oral health in patients scheduled for hematopoietic stem cell transplantation in the Orastem study

Skallsjö, Kristina,1976Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 1,Institute of Odontology, Section 1 (author)

Despite advances in transplant medicine, prevalence of complications after hematopoietic stem cell transplantation (HSCT) remains high. The impact of pre-HSCT oral health factors on the incidence and severity of complications post-HSCT is poorly understood. The aim of this prospective, observational study was to analyze oral health in patients planned for HSCT. Patients >= 18 years requiring HSCT were included from five sites between 2011-2018. General health, oral findings and patient-reported symptoms were registered in 272 patients. Oral symptoms around disease onset were reported by 43 patients (15.9%) and 153 patients (58.8%) reported oral complications during previous chemotherapy. One third of patients experienced oral symptoms at the oral examination before conditioning regimen and HSCT. In total, 124 (46.1%) patients had dental caries, 63 (29.0%) had >= one tooth with deep periodontal pockets, 147 (75.0%) had >= one tooth with bleeding on probing. Apical periodontitis was observed in almost 1/4 and partially impacted teeth in 17 (6.3%) patients. Oral mucosal lesions were observed in 84 patients (30.9%). A total of 45 (17.4%) of 259 patients had at least one acute issue to be managed prior to HSCT. In conclusion, oral symptoms and manifestations of oral disease were prevalent in patients planned for HSCT. The extent of oral and acute dental diseases calls for general oral screening of patients pre-HSCT.

von Bültzingslöwen, Inger,1947Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology(Swepub:gu)xvonin (author)
Hasséus, Bengt,1955Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 1,Institute of Odontology, Section 1(Swepub:gu)xhasbe (author)
Johansson, Jan-Erik,1963Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition (author)
Öhman, JennyGothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology(Swepub:gu)xohmje (author)
Raber-Durlacher, J. E. (author)
Huysmans, Mcdnjm (author)
Laheij, Amga (author)
van Leeuwen, S. J. M. (author)
Hovan, A. J. (author)
Legert, K. G.Karolinska Institutet (author)
Nguyen, H. M. (author)
Turk, P. J. (author)
Rozema, F. R. (author)
Blijlevens, N. M. A. (author)
Brennan, M. T. (author)
Göteborgs universitetInstitutionen för odontologi, sektion 1 (creator_code:org_t)

By the author/editor: Skallsjö, Kristi ...; von Bültzingslöw ...; Hasséus, Bengt, ...; Johansson, Jan-E ...; Öhman, Jenny; Raber-Durlacher, ...; show more...; Huysmans, Mcdnjm; Laheij, Amga; van Leeuwen, S. ...; Hovan, A. J.; Legert, K. G.; Nguyen, H. M.; Turk, P. J.; Rozema, F. R.; Blijlevens, N. M ...; Brennan, M. T.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.