Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.

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Fältnamn	Indikatorer	Metadata
000		07558nam a2201825 4500
001		oai:gup.ub.gu.se/332986
003		SwePub
008		240528s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:237886563
024	7	a https://gup.ub.gu.se/publication/3329862 URI
024	7	a https://doi.org/10.21203/rs.3.rs-3258813/v12 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:2378865632 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a ovr2 swepub-publicationtype
100	1	a Kelsoe, John4 aut
245	1 0	a Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.
264	1	c 2023
520		a Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2,039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
700	1	a Ou, Anna4 aut
700	1	a Rosenthal, Sara4 aut
700	1	a Adli, Mazda4 aut
700	1	a Akiyama, Kazufumi4 aut
700	1	a Akula, Nirmala4 aut
700	1	a Alda, Martin4 aut
700	1	a Amare, Azmeraw T4 aut
700	1	a Ardau, Raffaella4 aut
700	1	a Arias, Bárbara4 aut
700	1	a Aubry, Jean-Michel4 aut
700	1	a Backlund, Lenau Karolinska Institutet4 aut
700	1	a Banzato, Claudio4 aut
700	1	a Bauer, Michael4 aut
700	1	a Baune, Bernhard4 aut
700	1	a Bellivier, Frank4 aut
700	1	a Benabarre, Antonio4 aut
700	1	a Bengesser, Susanne4 aut
700	1	a Abesh, Bhattacharjee4 aut
700	1	a Biernacka, Joanna4 aut
700	1	a Bui, Elise4 aut
700	1	a Cervantes, Pablo4 aut
700	1	a Chen, Guo-Bo4 aut
700	1	a Chen, Hsi-Chung4 aut
700	1	a Chillotti, Caterinau Karolinska Institutet4 aut
700	1	a Cichon, Sven4 aut
700	1	a Clark, Scott4 aut
700	1	a Colom, Francesc4 aut
700	1	a Cousins, David4 aut
700	1	a Cruceanu, Cristiana4 aut
700	1	a Czerski, Piotr4 aut
700	1	a Dantas, Clarissa4 aut
700	1	a Dayer, Alexandre4 aut
700	1	a Degenhardt, Franziska4 aut
700	1	a DePaulo, J Raymond4 aut
700	1	a Etain, Bruno4 aut
700	1	a Falkai, Peter4 aut
700	1	a Fellendorf, Frederike4 aut
700	1	a Ferensztajn-Rochowiak, Ewa4 aut
700	1	a Forstner, Andreas J4 aut
700	1	a Frisen, Louiseu Karolinska Institutet4 aut
700	1	a Frye, Mark4 aut
700	1	a Fullerton, Janice4 aut
700	1	a Gard, Sebastien4 aut
700	1	a Garnham, Julie4 aut
700	1	a Goes, Fernando4 aut
700	1	a Grigoroiu-Serbanescu, Maria4 aut
700	1	a Grof, Paul4 aut
700	1	a Gruber, Oliver4 aut
700	1	a Hashimoto, Ryota4 aut
700	1	a Hauser, Joanna4 aut
700	1	a Heilbronner, Urs4 aut
700	1	a Herms, Stefan4 aut
700	1	a Hoffmann, Per4 aut
700	1	a Hofmann, Andrea4 aut
700	1	a Hou, Liping4 aut
700	1	a Jamain, Stéphane4 aut
700	1	a Jiménez, Esther4 aut
700	1	a Kahn, Jean-Pierre4 aut
700	1	a Kassem, Layla4 aut
700	1	a Kato, Tadafumi4 aut
700	1	a Kittel-Schneider, Sarah4 aut
700	1	a König, Barbara4 aut
700	1	a Kuo, Po-Hsiu4 aut
700	1	a Kusumi, Ichiro4 aut
700	1	a Dalkner, Nina4 aut
700	1	a Laje, Gonzalo4 aut
700	1	a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt
700	1	a Lavebratt, Catharina4 aut
700	1	a Leboyer, Marion4 aut
700	1	a Leckband, Susan4 aut
700	1	a Jaramillo, Carlos López4 aut
700	1	a MacQueen, Glenda4 aut
700	1	a Maj, Mariou Karolinska Institutet4 aut
700	1	a Manchia, Mirko4 aut
700	1	a Marie-Claire, Cynthia4 aut
700	1	a Martinsson, Linau Karolinska Institutet4 aut
700	1	a Mattheisen, Manuel4 aut
700	1	a McCarthy, Michael4 aut
700	1	a McElroy, Susan4 aut
700	1	a McMahon, Francis4 aut
700	1	a Mitchell, Philip4 aut
700	1	a Mitjans, Marina4 aut
700	1	a Mondimore, Francis4 aut
700	1	a Monteleone, Palmiero4 aut
700	1	a Nievergelt, Caroline4 aut
700	1	a Nöthen, Markus4 aut
700	1	a Novak, Tomas4 aut
700	1	a Osby, Urban4 aut
700	1	a Ozaki, Norio4 aut
700	1	a Papiol, Sergi4 aut
700	1	a Perlis, Roy4 aut
700	1	a Pfennig, Andrea4 aut
700	1	a Potash, James4 aut
700	1	a Reich-Erkelenz, Daniela4 aut
700	1	a Reif, Andreas4 aut
700	1	a Reininghaus, Eva4 aut
700	1	a Rietschel, Marcella4 aut
700	1	a Rouleau, Guy4 aut
700	1	a Rybakowski, Janusz K4 aut
700	1	a Schalling, Martin4 aut
700	1	a Schofield, Peter4 aut
700	1	a Schubert, Klaus Oliver4 aut
700	1	a Schulze, Thomas4 aut
700	1	a Schweizer, Barbara4 aut
700	1	a Seemüller, Florian4 aut
700	1	a Severino, Giovanni4 aut
700	1	a Shekhtman, Tatyana4 aut
700	1	a Shilling, Paul4 aut
700	1	a Shimoda, Kazutaka4 aut
700	1	a Simhandl, Christian4 aut
700	1	a Slaney, Claire4 aut
700	1	a Squassina, Alessio4 aut
700	1	a Stamm, Thomas4 aut
700	1	a Stopkova, Pavla4 aut
700	1	a Tighe, Sarah4 aut
700	1	a Tortorella, Alfonso4 aut
700	1	a Turecki, Gustavo4 aut
700	1	a Vieta, Eduard4 aut
700	1	a Volkert, Julia4 aut
700	1	a Witt, Stephanie4 aut
700	1	a Wray, Naomi4 aut
700	1	a Wright, Adam4 aut
700	1	a Young, Trevor4 aut
700	1	a Zandi, Peter4 aut
700	1	a Zompo, Maria Del4 aut
710	2	a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Research square
856	4 8	u https://gup.ub.gu.se/publication/332986
856	4 8	u https://doi.org/10.21203/rs.3.rs-3258813/v1
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:237886563

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Av författaren/redakt...: Kelsoe, John; Ou, Anna; Rosenthal, Sara; Adli, Mazda; Akiyama, Kazufum ...; Akula, Nirmala; visa fler...; Alda, Martin; Amare, Azmeraw T; Ardau, Raffaella; Arias, Bárbara; Aubry, Jean-Mich ...; Backlund, Lena; Banzato, Claudio; Bauer, Michael; Baune, Bernhard; Bellivier, Frank; Benabarre, Anton ...; Bengesser, Susan ...; Abesh, Bhattacha ...; Biernacka, Joann ...; Bui, Elise; Cervantes, Pablo; Chen, Guo-Bo; Chen, Hsi-Chung; Chillotti, Cater ...; Cichon, Sven; Clark, Scott; Colom, Francesc; Cousins, David; Cruceanu, Cristi ...; Czerski, Piotr; Dantas, Clarissa; Dayer, Alexandre; Degenhardt, Fran ...; DePaulo, J Raymo ...; Etain, Bruno; Falkai, Peter; Fellendorf, Fred ...; Ferensztajn-Roch ...; Forstner, Andrea ...; Frisen, Louise; Frye, Mark; Fullerton, Janic ...; Gard, Sebastien; Garnham, Julie; Goes, Fernando; Grigoroiu-Serban ...; Grof, Paul; Gruber, Oliver; Hashimoto, Ryota; Hauser, Joanna; Heilbronner, Urs; Herms, Stefan; Hoffmann, Per; Hofmann, Andrea; Hou, Liping; Jamain, Stéphane; Jiménez, Esther; Kahn, Jean-Pierr ...; Kassem, Layla; Kato, Tadafumi; Kittel-Schneider ...; König, Barbara; Kuo, Po-Hsiu; Kusumi, Ichiro; Dalkner, Nina; Laje, Gonzalo; Landén, Mikael, ...; Lavebratt, Catha ...; Leboyer, Marion; Leckband, Susan; Jaramillo, Carlo ...; MacQueen, Glenda; Maj, Mario; Manchia, Mirko; Marie-Claire, Cy ...; Martinsson, Lina; Mattheisen, Manu ...; McCarthy, Michae ...; McElroy, Susan; McMahon, Francis; Mitchell, Philip; Mitjans, Marina; Mondimore, Franc ...; Monteleone, Palm ...; Nievergelt, Caro ...; Nöthen, Markus; Novak, Tomas; Osby, Urban; Ozaki, Norio; Papiol, Sergi; Perlis, Roy; Pfennig, Andrea; Potash, James; Reich-Erkelenz, ...; Reif, Andreas; Reininghaus, Eva; Rietschel, Marce ...; Rouleau, Guy; Rybakowski, Janu ...; Schalling, Marti ...; Schofield, Peter; Schubert, Klaus ...; Schulze, Thomas; Schweizer, Barba ...; Seemüller, Flori ...; Severino, Giovan ...; Shekhtman, Tatya ...; Shilling, Paul; Shimoda, Kazutak ...; Simhandl, Christ ...; Slaney, Claire; Squassina, Aless ...; Stamm, Thomas; Stopkova, Pavla; Tighe, Sarah; Tortorella, Alfo ...; Turecki, Gustavo; Vieta, Eduard; Volkert, Julia; Witt, Stephanie; Wray, Naomi; Wright, Adam; Young, Trevor; Zandi, Peter; Zompo, Maria Del; visa färre...

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