Sökning: onr:"swepub:oai:gup.ub.gu.se/335712" > Toward ovarian canc...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03996naa a2200493 4500 | |
001 | oai:gup.ub.gu.se/335712 | |
003 | SwePub | |
008 | 240910s2024 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-523401 | |
024 | 7 | a https://gup.ub.gu.se/publication/3357122 URI |
024 | 7 | a https://doi.org/10.1016/j.isci.2024.1090012 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5234012 URI |
040 | a (SwePub)gud (SwePub)uu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hedlund Lindberg, Juliau Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)julin226 |
245 | 1 0 | a Toward ovarian cancer screening with protein biomarkers using dried, self-sampled cervico-vaginal fluid |
264 | 1 | b Cell Press,c 2024 |
520 | a Early detection is key for increased survival in ovarian cancer, but no general screening program exists today due to lack of biomarkers and overall cost versus benefit over traditional clinical methods. Here, we used dried cervico-vaginal fluid (CVF) as sampling matrix coupled with mass spectrometry for detection of protein biomarkers. We find that self-collected CVF on paper cards yields robust results and is suitable for high-throughput proteomics. Artificial intelligence–based methods were used to identify an 11-protein panel that separates cases from controls. In validation data, the panel achieved a sensitivity of 0.97 (95% CI 0.91–1.00) at a specificity of 0.67 (0.40–0.87). Analyses of samples collected prior to development of symptoms indicate that the panel is informative also of future risk of disease. Dried CVF is used in cervical cancer screening, and our results opens the possibility for a screening program also for ovarian cancer, based on self-collected CVF samples. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Body substance sample | |
653 | a Cancer | |
653 | a Fluid | |
653 | a Proteomics | |
653 | a Women's health | |
653 | a Body substance sample | |
700 | 1 | a Widgren, Annau Uppsala universitet,Analytisk kemi4 aut0 (Swepub:uu)gansc354 |
700 | 1 | a Ivansson, Emmau Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik och neurobiologi4 aut0 (Swepub:uu)emfra062 |
700 | 1 | a Gustavsson, Inger M.u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik och neurobiologi4 aut0 (Swepub:uu)ingergus |
700 | 1 | a Stålberg, Karinu Uppsala universitet,Reproduktiv hälsa4 aut0 (Swepub:uu)kariglim |
700 | 1 | a Gyllensten, Ulf B.u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik och neurobiologi4 aut0 (Swepub:uu)ulfgyll |
700 | 1 | a Sundfeldt, Karin,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsukar |
700 | 1 | a Bergquist, Jonasu Uppsala universitet,Analytisk kemi4 aut0 (Swepub:uu)jbe25356 |
700 | 1 | a Enroth, Stefan,d 1976-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Kollegiet för avancerade studier (SCAS),Genomik och neurobiologi4 aut0 (Swepub:uu)stenr451 |
710 | 2 | a Uppsala universitetb Institutionen för immunologi, genetik och patologi4 org |
773 | 0 | t iScienced : Cell Pressg 27:2q 27:2x 2589-0042 |
856 | 4 | u https://doi.org/10.1016/j.isci.2024.109001y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1838634/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/335712 |
856 | 4 8 | u https://doi.org/10.1016/j.isci.2024.109001 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523401 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.