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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03045naa a2200337 4500 | |
| 001 | oai:gup.ub.gu.se/337478 | |
| 003 | SwePub | |
| 008 | 240709s2024 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3374782 URI |
| 024 | 7 | a https://doi.org/10.1093/mr/roae0392 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hellman, Urban4 aut |
| 245 | 1 0 | a Immunological biomarkers in patients with radiographic axial spondyloarthritis, an exploratory longitudinal Swedish study. |
| 264 | 1 | c 2024 |
| 520 | a Objectives There is a need for more specific biomarkers to diagnose and predict disease course in patients with axial spondyloarthritis (axSpA). This study aimed to study immunological plasma biomarkers, at different time-points in radiographic (r)-axSpA patients overall and stratified by sex and compare these biomarker pattern in r-axSpA patients concerning disease phenotypes and disease activity. Methods Plasma samples were analysed from r-axSpA patients at and prior (Pre-Backbone) inclusion in the Backbone study. Interferon gamma, interleukin-10, -17A, -17F, -22, -23, -6, MCP-1, TNF-α, VEGF-A, MIF, IgA anti-CD74, zonulin, ESR, hsCRP, white blood cell count, and blood lipids were measured. Results Biomarker pattern discriminated significantly between r-axSpA patients in Backbone and Pre-Backbone compared with controls. When stratifying by sex, it was possible to discriminate between male and female r-axSpA patients in Backbone vs controls and between male r-axSpA patients in pre-Backbone and controls. In Backbone, markers with high discriminative capacity were MIF, IgA anti-CD74, and MCP-1. In Pre-Backbone, IL-6, TNF-α, MIF, triglycerides, cholesterol, IL-10, and zonulin displayed high discriminative capacity. Conclusion Based on their temporal pattern and mutual relationship, we suggest studying MIF, IgA anti-CD74, and MCP-1 in depth, at more time points, to further elucidate disease-driving mechanisms in this complex disease. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
| 700 | 1 | a Lejon, Kristina4 aut |
| 700 | 1 | a Do, Lan4 aut |
| 700 | 1 | a Geijer, Mats4 aut |
| 700 | 1 | a Baraliakos, Xenofon4 aut |
| 700 | 1 | a Witte, Torsten4 aut |
| 700 | 1 | a Forsblad d'Elia, Helena,d 1961u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xforhe |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning4 org |
| 773 | 0 | t Modern rheumatologyx 1439-7609 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/337478 |
| 856 | 4 8 | u https://doi.org/10.1093/mr/roae039 |
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