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Role of fibrinogen-...
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Jonsson, Ing-Marie,1949Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
(författare)
Role of fibrinogen-binding adhesin expression in septic arthritis and septicemia caused by Streptococcus agalactiae
- Artikel/kapitelEngelska2005
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LIBRIS-ID:oai:gup.ub.gu.se/43532
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https://gup.ub.gu.se/publication/43532URI
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Ämneskategori:art swepub-publicationtype
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BACKGROUND: Streptococcus agalactiae (group B streptococcus) is an important human pathogen that causes neonatal pneumonia, sepsis, septic arthritis, and meningitis, as well as severe infections in immunocompromised adult patients. The streptococci produce several molecules important for virulence. METHODS: We used a murine model of sepsis and septic arthritis to assess the role of FbsA, a fibrinogen-binding adhesin of S. agalactiae as a virulence determinant. NMRI mice were inoculated intravenously with S. agalactiae strains isogenic for the expression of FbsA. RESULTS: Inoculation with wild-type (wt) streptococci resulted in significantly higher mortality, more-pronounced weight decrease, and more-severe arthritis, compared with inoculation with the FbsA mutant isogenic strain. Neither active nor passive immunization with FbsA or FbsA-specific antibodies, respectively, resulted in any protection against subsequent infection with the S. agalactiae wt strain. CONCLUSION: Our results clearly indicate that the expression of FbsA by Streptococcus agalactiae is a significant virulence determinant in septic arthritis and septicemia. However, because blocking of the fibrinogen binding properties did not protect the host against the action of FbsA-expressing streptococci, we believe that the FbsA molecule has some other presently unknown biological in vivo properties.
Ämnesord och genrebeteckningar
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Animals
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Arthritis
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Infectious/*metabolism/microbiology/mortality
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Bacterial Adhesion/*physiology
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Bacterial Proteins/immunology/*physiology
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Carrier Proteins/immunology/*physiology
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Disease Models
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Animal
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Mice
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Sepsis/*metabolism/microbiology
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Streptococcus agalactiae/*pathogenicity/physiology
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Virulence/genetics
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Pietrocola, G.
(författare)
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Speziale, P.
(författare)
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Verdrengh, Margareta,1942Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research(Swepub:gu)xverma
(författare)
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Tarkowski, Andrej,1951Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research(Swepub:gu)xtaand
(författare)
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Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:J Infect Dis192:8, s. 1456-640022-1899
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