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  • Casselbrant, Anna,1970Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences (author)

Actions by angiotensin II on esophageal contractility in humans

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • Elsevier BV,2007

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/47804
  • https://gup.ub.gu.se/publication/47804URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:12538314URI
  • https://doi.org/10.1053/j.gastro.2006.11.010DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND & AIMS: Angiotensin II is a potent activator of smooth muscles but has not been much investigated with regard to gastrointestinal motor activity. This study explores expression of the renin-angiotensin system (RAS) in human esophageal musculature and actions by Angiotensin II both in vitro and in vivo. METHODS: Muscular specimens of esophageal body and lower esophageal sphincter were obtained from patients undergoing resection as a result of mucosal neoplasm. Healthy volunteers participated in functional examinations of esophageal motility assessed by high-resolution manometry and multiple transmucosal potential-difference measurements. RESULTS: Gene transcripts of key components of RAS were found in the esophageal musculature. Immunohistochemistry revealed a distinct staining for Angiotensin II type 1 (AT(1)) receptors in the muscular bundles and blood-vessel walls, whereas Angiotensin II type 2 receptors were confined to blood vessels only. Angiotensin II caused concentration-dependent contractions in vitro, which were inhibited by the AT(1) receptor antagonist losartan but not by the Angiotensin II type 2 receptor antagonist PD123319. Administration of the AT(1) receptor antagonist candesartan reduced the amplitude of swallow-induced peristaltic contractions and both the length and pressure amplitude of baseline high-pressure zone at the esophagogastric junction. Neither swallow-induced axial movements, nor the contraction after transient lower esophageal sphincter relaxations, were influenced by candesartan pretreatment. CONCLUSIONS: The study demonstrates a local RAS in the musculature of the distal esophagus and that Angiotensin II is a potent stimulator of esophageal contractions via the AT(1) receptor. The results suggest that Angiotensin II participates in the physiological control of the human esophageal motor activity.

Subject headings and genre

  • Aged
  • Aged
  • 80 and over
  • Angiotensin II/*pharmacology
  • Angiotensin II Type 1 Receptor Blockers/administration & dosage
  • Angiotensinogen/genetics
  • Benzimidazoles/administration & dosage
  • Esophageal Sphincter
  • Lower/*physiology
  • Esophagus/*physiology
  • Female
  • Gene Expression
  • Humans
  • Male
  • Manometry
  • Middle Aged
  • Muscle Contraction/*drug effects
  • Peptidyl-Dipeptidase A/genetics
  • Peristalsis/drug effects
  • Receptor
  • Angiotensin
  • Type 1/genetics/metabolism
  • Receptor
  • Angiotensin
  • Type 2/genetics/metabolism
  • Renin/genetics/metabolism
  • Tetrazoles/administration & dosage
  • Vasoconstrictor Agents/*pharmacology

Added entries (persons, corporate bodies, meetings, titles ...)

  • Edebo, Anders,1968Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xedean (author)
  • Wennerblom, Johanna,1969Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xwenjo (author)
  • Lönroth, Hans,1952Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xlonha (author)
  • Helander, Herbert F,1935Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xhelah (author)
  • Vieth, M. (author)
  • Lundell, L.Karolinska Institutet (author)
  • Fändriks, Lars,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xfanla (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper (creator_code:org_t)

Related titles

  • In:Gastroenterology: Elsevier BV132:1, s. 249-600016-5085

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