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Actions by angioten...
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Casselbrant, Anna,1970Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
(author)
Actions by angiotensin II on esophageal contractility in humans
- Article/chapterEnglish2007
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/47804
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https://gup.ub.gu.se/publication/47804URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:12538314URI
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https://doi.org/10.1053/j.gastro.2006.11.010DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND & AIMS: Angiotensin II is a potent activator of smooth muscles but has not been much investigated with regard to gastrointestinal motor activity. This study explores expression of the renin-angiotensin system (RAS) in human esophageal musculature and actions by Angiotensin II both in vitro and in vivo. METHODS: Muscular specimens of esophageal body and lower esophageal sphincter were obtained from patients undergoing resection as a result of mucosal neoplasm. Healthy volunteers participated in functional examinations of esophageal motility assessed by high-resolution manometry and multiple transmucosal potential-difference measurements. RESULTS: Gene transcripts of key components of RAS were found in the esophageal musculature. Immunohistochemistry revealed a distinct staining for Angiotensin II type 1 (AT(1)) receptors in the muscular bundles and blood-vessel walls, whereas Angiotensin II type 2 receptors were confined to blood vessels only. Angiotensin II caused concentration-dependent contractions in vitro, which were inhibited by the AT(1) receptor antagonist losartan but not by the Angiotensin II type 2 receptor antagonist PD123319. Administration of the AT(1) receptor antagonist candesartan reduced the amplitude of swallow-induced peristaltic contractions and both the length and pressure amplitude of baseline high-pressure zone at the esophagogastric junction. Neither swallow-induced axial movements, nor the contraction after transient lower esophageal sphincter relaxations, were influenced by candesartan pretreatment. CONCLUSIONS: The study demonstrates a local RAS in the musculature of the distal esophagus and that Angiotensin II is a potent stimulator of esophageal contractions via the AT(1) receptor. The results suggest that Angiotensin II participates in the physiological control of the human esophageal motor activity.
Subject headings and genre
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Aged
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Aged
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80 and over
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Angiotensin II/*pharmacology
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Angiotensin II Type 1 Receptor Blockers/administration & dosage
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Angiotensinogen/genetics
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Benzimidazoles/administration & dosage
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Esophageal Sphincter
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Lower/*physiology
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Esophagus/*physiology
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Female
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Gene Expression
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Humans
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Male
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Manometry
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Middle Aged
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Muscle Contraction/*drug effects
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Peptidyl-Dipeptidase A/genetics
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Peristalsis/drug effects
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Receptor
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Angiotensin
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Type 1/genetics/metabolism
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Receptor
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Angiotensin
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Type 2/genetics/metabolism
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Renin/genetics/metabolism
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Tetrazoles/administration & dosage
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Vasoconstrictor Agents/*pharmacology
Added entries (persons, corporate bodies, meetings, titles ...)
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Edebo, Anders,1968Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xedean
(author)
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Wennerblom, Johanna,1969Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xwenjo
(author)
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Lönroth, Hans,1952Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xlonha
(author)
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Helander, Herbert F,1935Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xhelah
(author)
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Vieth, M.
(author)
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Lundell, L.Karolinska Institutet
(author)
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Fändriks, Lars,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xfanla
(author)
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Göteborgs universitetInstitutionen för kliniska vetenskaper
(creator_code:org_t)
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In:Gastroenterology: Elsevier BV132:1, s. 249-600016-5085
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Gastroenterology
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University of Gothenburg
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Karolinska Institutet