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Candidate gene regi...
Candidate gene region 2q33 in European families with coeliac disease.
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Holopainen, Päivi (författare)
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- Torinsson Naluai, Åsa, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa,Institute for the Health of Women and Children
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Moodie, S (författare)
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Percopo, S (författare)
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Coto, I (författare)
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Clot, F (författare)
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- Ascher, Henry, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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Sollid, L. M. (författare)
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Ciclitira, P (författare)
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Greco, L (författare)
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Clerget-Darpoux, F (författare)
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Partanen, J (författare)
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(creator_code:org_t)
- Wiley, 2004
- 2004
- Engelska.
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Ingår i: Tissue antigens. - : Wiley. - 0001-2815 .- 1399-0039. ; 63:3, s. 212-22
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Chromosome region 2q33 harbours a cluster of genes, CTLA-4, CD28, ICOS and closely located PD-1, all related to immune activation and considered as promising candidate genes for susceptibility to coeliac disease (CD). We present here the results of a genetic linkage and association analysis of nine markers located in this gene region in a large combined European material of 796 families with CD from Finland, Sweden, Norway, UK, France and Italy. The joint analysis supports earlier findings that this susceptibility locus, assigned as CELIAC3, merits further studies. Nominally significant linkage to CD was found in 314 families including affected sib pairs. Each of the five populations showed weak associations to several marker alleles, but the analysis revealed, however, no conclusive evidence for a primary functional gene or gene variant present in the total set of families. The results suggest that the CD risk due to 2q33 gene region is complex and may involve more than one susceptibility allele, which possibly differ from other autoimmune diseases.
Nyckelord
- Alleles
- Antigens
- CD
- Antigens
- CD28
- genetics
- Antigens
- Differentiation
- genetics
- Antigens
- Differentiation
- T-Lymphocyte
- genetics
- Antigens
- Surface
- genetics
- Apoptosis Regulatory Proteins
- Celiac Disease
- genetics
- Chromosome Mapping
- Chromosomes
- Human
- Pair 2
- genetics
- Europe
- European Continental Ancestry Group
- genetics
- Female
- Gene Frequency
- Genetic Markers
- Genetic Predisposition to Disease
- Haplotypes
- genetics
- Humans
- Linkage (Genetics)
- Male
- Polymorphism
- Genetic
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Holopainen, Päiv ...
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Torinsson Naluai ...
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Moodie, S
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Percopo, S
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Coto, I
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Clot, F
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visa fler...
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Ascher, Henry, 1 ...
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Sollid, L. M.
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Ciclitira, P
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Greco, L
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Clerget-Darpoux, ...
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Partanen, J
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visa färre...
- Artiklar i publikationen
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Tissue antigens
- Av lärosätet
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Göteborgs universitet