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Sökning: onr:"swepub:oai:gup.ub.gu.se/66312" > IA-2 autoantibodies...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07543naa a2201333 4500 | |
| 001 | oai:gup.ub.gu.se/66312 | |
| 003 | SwePub | |
| 008 | 240528s2007 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-14463 | |
| 009 | oai:DiVA.org:liu-108702 | |
| 009 | oai:lup.lub.lu.se:bad435fe-dffe-4447-b4e0-e358ddc329e7 | |
| 009 | oai:prod.swepub.kib.ki.se:115877410 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/663122 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-144632 URI |
| 024 | 7 | a https://doi.org/10.1038/sj.gene.63644132 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1087022 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/11409022 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1158774102 URI |
| 040 | a (SwePub)gud (SwePub)uud (SwePub)liud (SwePub)lud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Shin, J. H.u Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada4 aut |
| 245 | 1 0 | a IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5 |
| 264 | 1 | b Springer Science and Business Media LLC,c 2007 |
| 520 | a In a large case-control study of Swedish incident type I diabetes patients and controls, 0-34 years of age, we tested the hypothesis that the GIMAP5 gene, a key genetic factor for lymphopenia in spontaneous BioBreeding rat diabetes, is associated with type I diabetes; with islet autoantibodies in incident type I diabetes patients or with age at clinical onset in incident type I diabetes patients. Initial scans of allelic association were followed by more detailed logistic regression modeling that adjusted for known type I diabetes risk factors and potential confounding variables. The single nucleotide polymorphism (SNP) rs6598, located in a polyadenylation signal of GIMAP5, was associated with the presence of significant levels of IA-2 autoantibodies in the type I diabetes patients. Patients with the minor allele A of rs6598 had an increased prevalence of IA-2 autoantibody levels compared to patients without the minor allele (OR=2.2; Bonferroni-corrected P=0.003), after adjusting for age at clinical onset (P=8.0 x 10(-13)) and the numbers of HLA-DQ A1*0501-B1*0201 haplotypes (P=2.4 x 10(-5)) and DQ A1*0301-B1*0302 haplotypes (P=0.002). GIMAP5 polymorphism was not associated with type I diabetes or with GAD65 or insulin autoantibodies, ICA, or age at clinical onset in patients. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same SNP in another autoimmune disease. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a Adolescent | |
| 653 | a Adult | |
| 653 | a Autoantibodies/blood/*immunology | |
| 653 | a Case-Control Studies | |
| 653 | a Child | |
| 653 | a Child | |
| 653 | a Preschool | |
| 653 | a Diabetes Mellitus | |
| 653 | a Type 1/*genetics/*immunology/metabolism | |
| 653 | a Female | |
| 653 | a GTP-Binding Proteins/*genetics/metabolism | |
| 653 | a Humans | |
| 653 | a Infant | |
| 653 | a Infant | |
| 653 | a Newborn | |
| 653 | a Male | |
| 653 | a Polymorphism | |
| 653 | a Single Nucleotide | |
| 653 | a Sweden | |
| 653 | a Adolescent | |
| 653 | a MEDICINE | |
| 653 | a polyadenylation signal | |
| 653 | a IA-2 autoantibodies | |
| 653 | a GIMAP5 | |
| 653 | a type I diabetes | |
| 700 | 1 | a Janer, M.u Institute for Systems Biology, Seattle, WA, USA4 aut |
| 700 | 1 | a McNeney, B.u Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada4 aut |
| 700 | 1 | a Blay, S.u Karolinska Institutet4 aut |
| 700 | 1 | a Deutsch, K.u Institute for Systems Biology, Seattle, WA, USA4 aut |
| 700 | 1 | a Sanjeevi, C. B.4 aut |
| 700 | 1 | a Kockum, I.u Karolinska Institutet4 aut |
| 700 | 1 | a Lernmark, Åkeu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 aut0 (Swepub:lu)endo-ale |
| 700 | 1 | a Graham, J.u Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada4 aut |
| 700 | 1 | a Arnqvist, H.u Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut |
| 700 | 1 | a Björck, E.4 aut |
| 700 | 1 | a Eriksson, J.4 aut |
| 700 | 1 | a Nystrom, L.4 aut |
| 700 | 1 | a Ohlson, L. O.4 aut |
| 700 | 1 | a Schersten, B.4 aut |
| 700 | 1 | a Östman, J.4 aut |
| 700 | 1 | a Aili, M.4 aut |
| 700 | 1 | a Baath, L. E.4 aut |
| 700 | 1 | a Carlsson, E.4 aut |
| 700 | 1 | a Edenwall, H.4 aut |
| 700 | 1 | a Forsander, Gun,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences4 aut0 (Swepub:gu)xfgunj |
| 700 | 1 | a Granström, B. W.4 aut |
| 700 | 1 | a Gustavsson, I.4 aut |
| 700 | 1 | a Hanas, R.4 aut |
| 700 | 1 | a Hellenberg, L.4 aut |
| 700 | 1 | a Hellgren, H.4 aut |
| 700 | 1 | a Holmberg, E.4 aut |
| 700 | 1 | a Hornell, H.4 aut |
| 700 | 1 | a Ivarsson, S. A.4 aut |
| 700 | 1 | a Johansson, C.4 aut |
| 700 | 1 | a Jonsell, G.4 aut |
| 700 | 1 | a Kockum, K.4 aut |
| 700 | 1 | a Lindblad, B.4 aut |
| 700 | 1 | a Lindh, A.4 aut |
| 700 | 1 | a Ludvigsson, Johnnyu Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping4 aut0 (Swepub:liu)johlu29 |
| 700 | 1 | a Myrdal, U.4 aut |
| 700 | 1 | a Neiderud, J.4 aut |
| 700 | 1 | a Segnestam, K.4 aut |
| 700 | 1 | a Sjöblad, S.4 aut |
| 700 | 1 | a Skogsberg, L.4 aut |
| 700 | 1 | a Stromberg, L.4 aut |
| 700 | 1 | a Stahle, U.4 aut |
| 700 | 1 | a Thalme, B.4 aut |
| 700 | 1 | a Tullus, K.4 aut |
| 700 | 1 | a Tuvemo, Tu Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson4 aut0 (Swepub:uu)torstuve |
| 700 | 1 | a Wallensteen, M.4 aut |
| 700 | 1 | a Westphal, O.4 aut |
| 700 | 1 | a Aman, J.u Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson4 aut |
| 700 | 1 | a Diabetes Incidence in Sweden Study Group, The4 aut |
| 700 | 1 | a Swedish Childhood Diabetes Study Group, The4 aut |
| 710 | 2 | a Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canadab Institute for Systems Biology, Seattle, WA, USA4 org |
| 773 | 0 | t Genes Immund : Springer Science and Business Media LLCg 8:6, s. 503-12q 8:6<503-12x 1466-4879x 1476-5470 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17641683&dopt=Citation |
| 856 | 4 | u https://www.nature.com/articles/6364413.pdf |
| 856 | 4 | u http://dx.doi.org/10.1038/sj.gene.6364413y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/66312 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14463 |
| 856 | 4 8 | u https://doi.org/10.1038/sj.gene.6364413 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-108702 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1140902 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:115877410 |
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