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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05395naa a2200781 4500 | |
| 001 | oai:gup.ub.gu.se/83841 | |
| 003 | SwePub | |
| 008 | 240528s1998 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:hj-3619 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/838412 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-36192 URI |
| 024 | 7 | a https://doi.org/10.1074/jbc.273.50.336102 DOI |
| 040 | a (SwePub)gud (SwePub)hj | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Larsson, Ku Department of Cell and Molecular Biology, Microbiology, Göteborg University, Göteborg, Sweden4 aut |
| 245 | 1 0 | a The Saccharomyces cerevisiae SOP1 and SOP2 genes, which act in cation homeostasis, can be functionally substituted by the Drosophila lethal(2)giant larvae tumor suppressor gene. |
| 264 | 1 | b Elsevier BV,c 1998 |
| 520 | a By complementation of a salt-sensitive mutant of Saccharomyces cerevisiae, we cloned the SOP1 gene, encoding a 114.5-kDa protein of 1033 amino acids. Cells deleted for SOP1 exhibited sensitivity to sodium stress, but showed no sensitivity to general osmotic stress. Following exposure of sop1Delta cells to NaCl stress, the intracellular Na+ level and the Na+/K+ ratio rose to values significantly higher than in wild type cells. Deletion of SOP2, encoding a protein sharing 54% amino acid identity with Sop1p, produced only slight Na+ sensitivity. Cells carrying a sop1Deltasop2Delta double deletion became, however, hypersensitive to Na+ and exhibited increased sensitivity also to Li+ and K+, suggesting involvement of both SOP1 and SOP2 in cation homeostasis. The predicted amino acid sequences of Sop1p and Sop2p show significant homologies with the cytoskeletal-associated protein encoded by the Drosophila lethal(2)giant larvae tumor suppressor gene. Immunolocalization of Sop1p revealed a cytoplasmic distribution and cell fractionation studies showed that a significant fraction of Sop1p was recovered in a sedimentable fraction of the cytosolic material. Expression of a Drosophila l(2)gl cDNA in the sop1Deltasop2Delta strain partially restored the Na+ tolerance of the cells, indicating a functional relationship between the Sop proteins and the tumor suppressor protein, and a novel function in cell homeostasis for this family of proteins extending from yeast to human. | |
| 650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
| 653 | a Amino Acid Sequence | |
| 653 | a Animals | |
| 653 | a Base Sequence | |
| 653 | a Carrier Proteins | |
| 653 | a chemistry | |
| 653 | a genetics | |
| 653 | a Cytoplasm | |
| 653 | a metabolism | |
| 653 | a DNA Primers | |
| 653 | a Drosophila | |
| 653 | a genetics | |
| 653 | a Gene Expression Regulation | |
| 653 | a Fungal | |
| 653 | a Genes | |
| 653 | a Tumor Suppressor | |
| 653 | a Genetic Complementation Test | |
| 653 | a Homeostasis | |
| 653 | a Humans | |
| 653 | a Molecular Sequence Data | |
| 653 | a Mutation | |
| 653 | a Saccharomyces cerevisiae | |
| 653 | a genetics | |
| 653 | a Saccharomyces cerevisiae Proteins | |
| 653 | a Sequence Homology | |
| 653 | a Amino Acid | |
| 653 | a Sodium | |
| 653 | a metabolism | |
| 653 | a Amino Acid Sequence | |
| 700 | 1 | a Böhl, Fu Department of Developmental Genetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany4 aut |
| 700 | 1 | a Sjöström, Ingridu Jönköping University,Tekniska Högskolan,Department of Cell and Molecular Biology, Microbiology, Göteborg University, Göteborg, Sweden4 aut0 (Swepub:hj)wain |
| 700 | 1 | a Akhtar, Nu Department of Cell and Molecular Biology, Microbiology, Göteborg University, Göteborg, Sweden4 aut |
| 700 | 1 | a Strand, Du Department of Developmental Genetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany4 aut |
| 700 | 1 | a Mechler, B Mu Department of Developmental Genetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany4 aut |
| 700 | 1 | a Grabowski, Ru Department of Cell and Molecular Biology, Microbiology, Göteborg University, Göteborg, Sweden4 aut |
| 700 | 1 | a Adler, Lennart,d 1944u Gothenburg University,Göteborgs universitet,Botaniska institutionen,Botanical Institute,Department of Cell and Molecular Biology, Microbiology, Göteborg University, Göteborg, Sweden4 aut0 (Swepub:gu)xadlle |
| 710 | 2 | a Department of Cell and Molecular Biology, Microbiology, Göteborg University, Göteborg, Swedenb Department of Developmental Genetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany4 org |
| 773 | 0 | t The Journal of biological chemistryd : Elsevier BVg 273:50, s. 33610-8q 273:50<33610-8x 0021-9258x 1083-351X |
| 856 | 4 | u https://doi.org/10.1074/jbc.273.50.33610y Fulltext |
| 856 | 4 | u https://hj.diva-portal.org/smash/get/diva2:34439/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u http://www.jbc.org/content/273/50/33610.full.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/83841 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-3619 |
| 856 | 4 8 | u https://doi.org/10.1074/jbc.273.50.33610 |
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