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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04198naa a2200877 4500 | |
| 001 | oai:gup.ub.gu.se/85337 | |
| 003 | SwePub | |
| 008 | 240528s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/853372 URI |
| 024 | 7 | a https://doi.org/10.1016/j.vaccine.2007.09.0732 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Cuburu, Nicolas4 aut |
| 245 | 1 0 | a Sublingual immunization induces broad-based systemic and mucosal immune responses in mice. |
| 264 | 1 | b Elsevier BV,c 2007 |
| 520 | a The potential of sublingual (s.l.) delivery of vaccine was examined in mice. We show the existence of a dense network of dendritic cells (DCs) in the s.l. epithelium and a rapid and transient increase in the frequency of s.l. DCs after topical application of cholera toxin (CT) adjuvant under the tongue. S.l. immunization with ovalbumin and CT induced vigorous systemic and mucosal antibody responses. Such treatment promoted mixed Th1 and Th2 cytokine responses and induced cytotoxic CD8(+) T cells in lung tissues and in systemic lymphoid organs. S.l. immunization was comparable to intranasal immunization and was superior to oral immunization regarding the magnitude and anatomic dissemination of the induced immune responses. S.l. administration of live influenza virus at a dose lethal by the nasal route was well tolerated and did not redirect virus to the olfactory bulb. These features underscore the potential of the s.l. mucosa to serve as an alternative vaccine delivery route. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
| 653 | a Adjuvants | |
| 653 | a Immunologic | |
| 653 | a Administration | |
| 653 | a Sublingual | |
| 653 | a Adoptive Transfer | |
| 653 | a Animals | |
| 653 | a Antibodies | |
| 653 | a Viral | |
| 653 | a analysis | |
| 653 | a biosynthesis | |
| 653 | a Antibody-Producing Cells | |
| 653 | a CD4-Positive T-Lymphocytes | |
| 653 | a immunology | |
| 653 | a CD8-Positive T-Lymphocytes | |
| 653 | a immunology | |
| 653 | a Cholera Toxin | |
| 653 | a immunology | |
| 653 | a Cytokines | |
| 653 | a biosynthesis | |
| 653 | a Dendritic Cells | |
| 653 | a immunology | |
| 653 | a Dose-Response Relationship | |
| 653 | a Immunologic | |
| 653 | a Female | |
| 653 | a Flow Cytometry | |
| 653 | a Immunity | |
| 653 | a Mucosal | |
| 653 | a immunology | |
| 653 | a Immunization | |
| 653 | a methods | |
| 653 | a Immunohistochemistry | |
| 653 | a Mice | |
| 653 | a Mice | |
| 653 | a Inbred BALB C | |
| 653 | a Mice | |
| 653 | a Inbred C57BL | |
| 653 | a Mouth Mucosa | |
| 653 | a cytology | |
| 653 | a immunology | |
| 653 | a Ovalbumin | |
| 653 | a immunology | |
| 653 | a Reverse Transcriptase Polymerase Chain Reaction | |
| 700 | 1 | a Kweon, Mi-Na4 aut |
| 700 | 1 | a Song, Joo-Hye4 aut |
| 700 | 1 | a Hervouet, Catherine4 aut |
| 700 | 1 | a Luci, Carmelo4 aut |
| 700 | 1 | a Sun, Jia-Bin,d 1948u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xsunji |
| 700 | 1 | a Hofman, Paul4 aut |
| 700 | 1 | a Holmgren, Jan,d 1944u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xholja |
| 700 | 1 | a Anjuère, Fabienne4 aut |
| 700 | 1 | a Czerkinsky, Cecil4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi4 org |
| 773 | 0 | t Vaccined : Elsevier BVg 25:51, s. 8598-610q 25:51<8598-610x 0264-410X |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/85337 |
| 856 | 4 8 | u https://doi.org/10.1016/j.vaccine.2007.09.073 |
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