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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04785naa a2200913 4500 | |
| 001 | oai:gup.ub.gu.se/98790 | |
| 003 | SwePub | |
| 008 | 240410s2009 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:118755580 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/987902 URI |
| 024 | 7 | a https://doi.org/10.1136/jnnp.2008.1546332 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1187555802 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Blahak, C4 aut |
| 245 | 1 0 | a Deep frontal and periventricular age related white matter changes but not basal ganglia and infratentorial hyperintensities are associated with falls: cross sectional results from the LADIS study. |
| 264 | c 2009-02-09 | |
| 264 | 1 | b BMJ,c 2009 |
| 520 | a BACKGROUND: Global age related white matter changes (ARWMC) are associated with progressive gait disturbances and falls, hypothesised to result from interruptions of cortico-subcortical circuits controlling balance, posture and locomotion. METHODS: The location of ARWMC in a large cohort of elderly non-disabled individuals with reported falls was analysed, using the cross sectional data of the Leukoaraiosis and Disability (LADIS) study. Detailed anatomical distributions of ARWMC assessed by MRI studies were analysed with respect to falls and balance performance. RESULTS: The severity of global ARWMC was significantly associated with a history of falls in the year prior to study inclusion (22.2% in the mild, 31.6% in the moderate and 37.3% in the severe ARWMC group according to the Fazekas scale; p = 0.002). Analysing the anatomical distribution of ARWMC, using the semiquantitative Scheltens scale, in multivariate analysis, periventricular (p = 0.006) and frontal deep (p = 0.033) ARWMC were independently associated with falls. Furthermore, logistic regression identified frontal deep (p = 0.003) ARWMC, but not basal ganglia and infratentorial hyperintensities, as significantly associated with balance disturbances. CONCLUSION: The association of frontal and periventricular ARWMC with falls supports the hypothesis that interruption of frontal subcortical motor circuits lead to balance disturbances and hence to an increased risk for falls in ARWMC. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 653 | a Accidental Falls | |
| 653 | a Aged | |
| 653 | a Aged | |
| 653 | a 80 and over | |
| 653 | a Basal Ganglia | |
| 653 | a pathology | |
| 653 | a Cerebellum | |
| 653 | a pathology | |
| 653 | a Cerebral Ventricles | |
| 653 | a pathology | |
| 653 | a Cross-Sectional Studies | |
| 653 | a Disability Evaluation | |
| 653 | a Europe | |
| 653 | a Female | |
| 653 | a Follow-Up Studies | |
| 653 | a Frontal Lobe | |
| 653 | a pathology | |
| 653 | a Gait Disorders | |
| 653 | a Neurologic | |
| 653 | a diagnosis | |
| 653 | a pathology | |
| 653 | a Humans | |
| 653 | a Leukoaraiosis | |
| 653 | a diagnosis | |
| 653 | a pathology | |
| 653 | a Magnetic Resonance Imaging | |
| 653 | a Male | |
| 653 | a Nerve Fibers | |
| 653 | a Myelinated | |
| 653 | a pathology | |
| 653 | a Nerve Net | |
| 653 | a pathology | |
| 653 | a Postural Balance | |
| 653 | a physiology | |
| 700 | 1 | a Baezner, H4 aut |
| 700 | 1 | a Pantoni, L4 aut |
| 700 | 1 | a Poggesi, A4 aut |
| 700 | 1 | a Chabriat, H4 aut |
| 700 | 1 | a Erkinjuntti, T4 aut |
| 700 | 1 | a Fazekas, F4 aut |
| 700 | 1 | a Ferro, J M4 aut |
| 700 | 1 | a Langhorne, P4 aut |
| 700 | 1 | a O'Brien, J4 aut |
| 700 | 1 | a Visser, M C4 aut |
| 700 | 1 | a Wahlund, L-Ou Karolinska Institutet4 aut |
| 700 | 1 | a Waldemar, G4 aut |
| 700 | 1 | a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xwaand |
| 700 | 1 | a Inzitari, D4 aut |
| 700 | 1 | a Hennerici, M G4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Journal of neurology, neurosurgery, and psychiatryd : BMJg 80:6, s. 608-13q 80:6<608-13x 1468-330Xx 0022-3050 |
| 856 | 4 | u https://research.vumc.nl/ws/files/172580/237646.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/98790 |
| 856 | 4 8 | u https://doi.org/10.1136/jnnp.2008.154633 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:118755580 |
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- Blahak, C
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