Search: onr:"swepub:oai:lup.lub.lu.se:06878129-f8e8-467a-9157-70455386518a" >
Seventy-five geneti...
Seventy-five genetic loci influencing the human red blood cell
-
van der Harst, Pim (author)
-
Zhang, Weihua (author)
-
Leach, Irene Mateo (author)
-
show more...
-
Rendon, Augusto (author)
-
Verweij, Niek (author)
-
Sehmi, Joban (author)
-
Paul, Dirk S. (author)
-
Elling, Ulrich (author)
-
Allayee, Hooman (author)
-
Li, Xinzhong (author)
-
Radhakrishnan, Aparna (author)
-
Tan, Sian-Tsung (author)
-
Voss, Katrin (author)
-
Weichenberger, Christian X. (author)
-
Albers, Cornelis A. (author)
-
Al-Hussani, Abtehale (author)
-
Asselbergs, Folkert W. (author)
-
Ciullo, Marina (author)
-
Danjou, Fabrice (author)
-
Dina, Christian (author)
-
Esko, Tonu (author)
-
Evans, David M. (author)
-
Franke, Lude (author)
-
Goegele, Martin (author)
-
Hartiala, Jaana (author)
-
Hersch, Micha (author)
-
Holm, Hilma (author)
-
Hottenga, Jouke-Jan (author)
-
Kanoni, Stavroula (author)
-
Kleber, Marcus E. (author)
-
Lagou, Vasiliki (author)
-
Langenberg, Claudia (author)
-
Lopez, Lorna M. (author)
-
Lyytikainen, Leo-Pekka (author)
-
- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
-
Murgia, Federico (author)
-
Nolte, Ilja M. (author)
-
O'Reilly, Paul F. (author)
-
Padmanabhan, Sandosh (author)
-
Parsa, Afshin (author)
-
Pirastu, Nicola (author)
-
Porcu, Eleonora (author)
-
Portas, Laura (author)
-
Prokopenko, Inga (author)
-
Ried, Janina S. (author)
-
Shin, So-Youn (author)
-
Tang, Clara S. (author)
-
Teumer, Alexander (author)
-
Traglia, Michela (author)
-
Ulivi, Sheila (author)
-
Westra, Harm-Jan (author)
-
Yang, Jian (author)
-
Zhao, Jing Hua (author)
-
Anni, Franco (author)
-
Abdellaoui, Abdel (author)
-
Attwood, Antony (author)
-
Balkau, Beverley (author)
-
Bandinelli, Stefania (author)
-
Bastardot, Francois (author)
-
Benyamin, Beben (author)
-
Boehm, Bernhard O. (author)
-
Cookson, William O. (author)
-
Das, Debashish (author)
-
de Bakker, Paul I. W. (author)
-
de Boer, Rudolf A. (author)
-
de Geus, Eco J. C. (author)
-
de Moor, Marleen H. (author)
-
Dimitriou, Maria (author)
-
Domingues, Francisco S. (author)
-
Doering, Angela (author)
-
- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
-
Eyjolfsson, Gudmundur Ingi (author)
-
Ferrucci, Luigi (author)
-
Fischer, Krista (author)
-
Galanello, Renzo (author)
-
Garner, Stephen F. (author)
-
Genser, Bernd (author)
-
Gibson, Quince D. (author)
-
Girotto, Giorgia (author)
-
Gudbjartsson, Daniel Fannar (author)
-
Harris, Sarah E. (author)
-
Hartikainen, Anna-Liisa (author)
-
Hastie, Claire E. (author)
-
- Hedblad, Bo (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
-
Illig, Thomas (author)
-
Jolley, Jennifer (author)
-
Kahonen, Mika (author)
-
Kema, Ido P. (author)
-
Kemp, John P. (author)
-
Liang, Liming (author)
-
Lloyd-Jones, Heather (author)
-
Loos, Ruth J. F. (author)
-
Meacham, Stuart (author)
-
Medland, Sarah E. (author)
-
Meisinger, Christa (author)
-
Memari, Yasin (author)
-
Mihailov, Evelin (author)
-
Miller, Kathy (author)
-
Moffatt, Miriam F. (author)
-
Nauck, Matthias (author)
-
Novatchkova, Maria (author)
-
Nutile, Teresa (author)
-
Olafsson, Isleifur (author)
-
Onundarson, Pall T. (author)
-
Parracciani, Debora (author)
-
Penninx, Brenda W. (author)
-
Perseu, Lucia (author)
-
Piga, Antonio (author)
-
Pistis, Giorgio (author)
-
Pouta, Anneli (author)
-
Puc, Ursula (author)
-
Raitakari, Olli (author)
-
Ring, Susan M. (author)
-
Robino, Antonietta (author)
-
Ruggiero, Daniela (author)
-
Ruokonen, Aimo (author)
-
Saint-Pierre, Aude (author)
-
Sala, Cinzia (author)
-
Salumets, Andres (author)
-
Sambrook, Jennifer (author)
-
Schepers, Hein (author)
-
Schmidt, Carsten Oliver (author)
-
Sillje, Herman H. W. (author)
-
Sladek, Rob (author)
-
Smit, Johannes H. (author)
-
Starr, John M. (author)
-
Stephens, Jonathan (author)
-
Sulem, Patrick (author)
-
Tanaka, Toshiko (author)
-
Thorsteinsdottir, Unnur (author)
-
Tragante, Vinicius (author)
-
van Gilst, Wiek H. (author)
-
van Pelt, L. Joost (author)
-
van Veldhuisen, Dirk J. (author)
-
Voelker, Uwe (author)
-
Whitfield, John B. (author)
-
Willemsen, Gonneke (author)
-
Winkelmann, Bernhard R. (author)
-
Wirnsberger, Gerald (author)
-
Algra, Ale (author)
-
Cucca, Francesco (author)
-
d'Adamo, Adamo Pio (author)
-
Danesh, John (author)
-
Deary, Ian J. (author)
-
Dominiczak, Anna F. (author)
-
Elliott, Paul (author)
-
Fortina, Paolo (author)
-
Froguel, Philippe (author)
-
Gasparini, Paolo (author)
-
Greinacher, Andreas (author)
-
Hazen, Stanley L. (author)
-
Jarvelin, Marjo-Riitta (author)
-
Khaw, Kay Tee (author)
-
Lehtimaki, Terho (author)
-
Maerz, Winfried (author)
-
Martin, Nicholas G. (author)
-
Metspalu, Andres (author)
-
Mitchell, Braxton D. (author)
-
Montgomery, Grant W. (author)
-
Moore, Carmel (author)
-
Navis, Gerjan (author)
-
Pirastu, Mario (author)
-
Pramstaller, Peter P. (author)
-
Ramirez-Solis, Ramiro (author)
-
Schadt, Eric (author)
-
Scott, James (author)
-
Shuldiner, Alan R. (author)
-
Smith, George Davey (author)
-
- Smith, Gustav (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
-
Snieder, Harold (author)
-
Sorice, Rossella (author)
-
Spector, Tim D. (author)
-
Stefansson, Kari (author)
-
Stumvoll, Michael (author)
-
Tang, W. H. Wilson (author)
-
Toniolo, Daniela (author)
-
Toenjes, Anke (author)
-
Visscher, Peter M. (author)
-
Vollenweider, Peter (author)
-
Wareham, Nicholas J. (author)
-
Wolffenbuttel, Bruce H. R. (author)
-
Boomsma, Dorret I. (author)
-
Beckmann, Jacques S. (author)
-
Dedoussis, George V. (author)
-
Deloukas, Panos (author)
-
Ferreira, Manuel A. (author)
-
Sanna, Serena (author)
-
Uda, Manuela (author)
-
Hicks, Andrew A. (author)
-
Penninger, Josef Martin (author)
-
Gieger, Christian (author)
-
Kooner, Jaspal S. (author)
-
Ouwehand, Willem H. (author)
-
Soranzo, Nicole (author)
-
Chambers, John C. (author)
-
show less...
-
(creator_code:org_t)
- 2012-12-05
- 2012
- English.
-
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 492:7429, s. 369-375
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://serval.unil....
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10(-8), which together explain 4-9% of the phenotypic variance per trait. Using expression quantitative trait loci and bioinformatic strategies, we identify 121 candidate genes enriched in functions relevant to red blood cell biology. The candidate genes are expressed preferentially in red blood cell precursors, and 43 have haematopoietic phenotypes in Mus musculus or Drosophila melanogaster. Through open-chromatin and coding-variant analyses we identify potential causal genetic variants at 41 loci. Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
Nature
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
van der Harst, P ...
-
Zhang, Weihua
-
Leach, Irene Mat ...
-
Rendon, Augusto
-
Verweij, Niek
-
Sehmi, Joban
-
show more...
-
Paul, Dirk S.
-
Elling, Ulrich
-
Allayee, Hooman
-
Li, Xinzhong
-
Radhakrishnan, A ...
-
Tan, Sian-Tsung
-
Voss, Katrin
-
Weichenberger, C ...
-
Albers, Cornelis ...
-
Al-Hussani, Abte ...
-
Asselbergs, Folk ...
-
Ciullo, Marina
-
Danjou, Fabrice
-
Dina, Christian
-
Esko, Tonu
-
Evans, David M.
-
Franke, Lude
-
Goegele, Martin
-
Hartiala, Jaana
-
Hersch, Micha
-
Holm, Hilma
-
Hottenga, Jouke- ...
-
Kanoni, Stavroul ...
-
Kleber, Marcus E ...
-
Lagou, Vasiliki
-
Langenberg, Clau ...
-
Lopez, Lorna M.
-
Lyytikainen, Leo ...
-
Melander, Olle
-
Murgia, Federico
-
Nolte, Ilja M.
-
O'Reilly, Paul F ...
-
Padmanabhan, San ...
-
Parsa, Afshin
-
Pirastu, Nicola
-
Porcu, Eleonora
-
Portas, Laura
-
Prokopenko, Inga
-
Ried, Janina S.
-
Shin, So-Youn
-
Tang, Clara S.
-
Teumer, Alexande ...
-
Traglia, Michela
-
Ulivi, Sheila
-
Westra, Harm-Jan
-
Yang, Jian
-
Zhao, Jing Hua
-
Anni, Franco
-
Abdellaoui, Abde ...
-
Attwood, Antony
-
Balkau, Beverley
-
Bandinelli, Stef ...
-
Bastardot, Franc ...
-
Benyamin, Beben
-
Boehm, Bernhard ...
-
Cookson, William ...
-
Das, Debashish
-
de Bakker, Paul ...
-
de Boer, Rudolf ...
-
de Geus, Eco J. ...
-
de Moor, Marleen ...
-
Dimitriou, Maria
-
Domingues, Franc ...
-
Doering, Angela
-
Engström, Gunnar
-
Eyjolfsson, Gudm ...
-
Ferrucci, Luigi
-
Fischer, Krista
-
Galanello, Renzo
-
Garner, Stephen ...
-
Genser, Bernd
-
Gibson, Quince D ...
-
Girotto, Giorgia
-
Gudbjartsson, Da ...
-
Harris, Sarah E.
-
Hartikainen, Ann ...
-
Hastie, Claire E ...
-
Hedblad, Bo
-
Illig, Thomas
-
Jolley, Jennifer
-
Kahonen, Mika
-
Kema, Ido P.
-
Kemp, John P.
-
Liang, Liming
-
Lloyd-Jones, Hea ...
-
Loos, Ruth J. F.
-
Meacham, Stuart
-
Medland, Sarah E ...
-
Meisinger, Chris ...
-
Memari, Yasin
-
Mihailov, Evelin
-
Miller, Kathy
-
Moffatt, Miriam ...
-
Nauck, Matthias
-
Novatchkova, Mar ...
-
Nutile, Teresa
-
Olafsson, Isleif ...
-
Onundarson, Pall ...
-
Parracciani, Deb ...
-
Penninx, Brenda ...
-
Perseu, Lucia
-
Piga, Antonio
-
Pistis, Giorgio
-
Pouta, Anneli
-
Puc, Ursula
-
Raitakari, Olli
-
Ring, Susan M.
-
Robino, Antoniet ...
-
Ruggiero, Daniel ...
-
Ruokonen, Aimo
-
Saint-Pierre, Au ...
-
Sala, Cinzia
-
Salumets, Andres
-
Sambrook, Jennif ...
-
Schepers, Hein
-
Schmidt, Carsten ...
-
Sillje, Herman H ...
-
Sladek, Rob
-
Smit, Johannes H ...
-
Starr, John M.
-
Stephens, Jonath ...
-
Sulem, Patrick
-
Tanaka, Toshiko
-
Thorsteinsdottir ...
-
Tragante, Vinici ...
-
van Gilst, Wiek ...
-
van Pelt, L. Joo ...
-
van Veldhuisen, ...
-
Voelker, Uwe
-
Whitfield, John ...
-
Willemsen, Gonne ...
-
Winkelmann, Bern ...
-
Wirnsberger, Ger ...
-
Algra, Ale
-
Cucca, Francesco
-
d'Adamo, Adamo P ...
-
Danesh, John
-
Deary, Ian J.
-
Dominiczak, Anna ...
-
Elliott, Paul
-
Fortina, Paolo
-
Froguel, Philipp ...
-
Gasparini, Paolo
-
Greinacher, Andr ...
-
Hazen, Stanley L ...
-
Jarvelin, Marjo- ...
-
Khaw, Kay Tee
-
Lehtimaki, Terho
-
Maerz, Winfried
-
Martin, Nicholas ...
-
Metspalu, Andres
-
Mitchell, Braxto ...
-
Montgomery, Gran ...
-
Moore, Carmel
-
Navis, Gerjan
-
Pirastu, Mario
-
Pramstaller, Pet ...
-
Ramirez-Solis, R ...
-
Schadt, Eric
-
Scott, James
-
Shuldiner, Alan ...
-
Smith, George Da ...
-
Smith, Gustav
-
Snieder, Harold
-
Sorice, Rossella
-
Spector, Tim D.
-
Stefansson, Kari
-
Stumvoll, Michae ...
-
Tang, W. H. Wils ...
-
Toniolo, Daniela
-
Toenjes, Anke
-
Visscher, Peter ...
-
Vollenweider, Pe ...
-
Wareham, Nichola ...
-
Wolffenbuttel, B ...
-
Boomsma, Dorret ...
-
Beckmann, Jacque ...
-
Dedoussis, Georg ...
-
Deloukas, Panos
-
Ferreira, Manuel ...
-
Sanna, Serena
-
Uda, Manuela
-
Hicks, Andrew A.
-
Penninger, Josef ...
-
Gieger, Christia ...
-
Kooner, Jaspal S ...
-
Ouwehand, Willem ...
-
Soranzo, Nicole
-
Chambers, John C ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
Nature
- By the university
-
Lund University