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Sökning: onr:"swepub:oai:lup.lub.lu.se:0bf63004-af4c-4d51-b5c9-f2d78f04da41" > Association of Gene...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005635naa a2200433 4500
001oai:lup.lub.lu.se:0bf63004-af4c-4d51-b5c9-f2d78f04da41
003SwePub
008190129s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:140561307
0247 a https://lup.lub.lu.se/record/0bf63004-af4c-4d51-b5c9-f2d78f04da412 URI
0247 a https://doi.org/10.1001/jamaoto.2018.38522 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1405613072 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Cederroth, Christopher R.u Karolinska Institutet,Karolinska Institute4 aut
2451 0a Association of Genetic vs Environmental Factors in Swedish Adoptees with Clinically Significant Tinnitus
264 1b American Medical Association (AMA),c 2019
520 a Importance: No effective treatments are currently available for severe tinnitus, which affects 1% of the population and lowers the quality of life. The factors that contribute to the transition from mild to severe tinnitus are poorly known. Before performing genetic analyses and determining the mechanisms involved in the development of severe tinnitus, its heritability needs to be determined. Objectives: To examine whether clinically significant tinnitus is associated with genetic factors and to evaluate the genetic risk in the transmission of tinnitus using adoptees. Design, Setting, and Participants: Data from adoptees and their biological and adoptive parents from Swedish nationwide registers were collected from January 1, 1964, to December 31, 2015, and used to separate genetic from environmental factors in familial clustering. In all, 11 060 adoptees, 19 015 adoptive parents, and 17 025 biological parents were investigated. The study used a cohort design and a case-control approach to study genetic and nongenetic factors in tinnitus among adoptees. Main Outcomes and Measures: The primary outcome was odds ratio (OR) of tinnitus in adoptees with at least 1 affected biological parent compared with adoptees without any affected biological parent using logistic regression. The secondary outcome was OR in adoptees with at least 1 affected adoptive parent compared with adoptees without any affected adoptive parent. Results: A total of 1029 patients (440 [42.8%] male; mean [SD] age, 62 [14] years) with tinnitus were identified. The prevalence of diagnosed tinnitus was 2.2%. The OR for tinnitus was 2.22 for adoptees (95% CI, 1.03-4.81) of biological parents diagnosed with tinnitus, whereas the OR was 1.00 (95% CI, 0.43-2.32) for adoptees from adoptive parents diagnosed with tinnitus. Mean (SE) heritability determined using tetrachoric correlations was 31% (14%). Conclusions and Relevance: The findings suggest that genetic factors are associated with the familial clustering of clinically significant tinnitus with no shared-environment association, revealing that the transition from negligible to severe tinnitus may be associated with genetic factors. These findings may provide insight for future genetic analyses that focus on severe tinnitus..
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Oto-rhino-laryngologi0 (SwePub)302182 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Otorhinolaryngology0 (SwePub)302182 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
7001 a Pirouzifard, Mirnabiu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)stat-mpi
7001 a Trpchevska, Nataliau Karolinska Institutet,Karolinska Institute4 aut
7001 a Idrizbegovic, Esmau Karolinska Institutet,Karolinska University Hospital4 aut
7001 a Canlon, Barbarau Karolinska Institutet,Karolinska Institute4 aut
7001 a Sundquist, Janu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-jsu
7001 a Sundquist, Kristinau Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups4 aut0 (Swepub:lu)med-ksq
7001 a Zöller, Bengtu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-bzo
7102 a Karolinska Institutetb Karolinska Institute4 org
7730 t JAMA Otolaryngology - Head and Neck Surgeryd : American Medical Association (AMA)g 145:3, s. 222-229q 145:3<222-229x 2168-6181x 2168-619X
8564 u http://dx.doi.org/10.1001/jamaoto.2018.3852y FULLTEXT
8564 u https://jamanetwork.com/journals/jamaotolaryngology/articlepdf/2721030/jamaotolaryngology_cederroth_2019_oi_180103.pdf
8564 8u https://lup.lub.lu.se/record/0bf63004-af4c-4d51-b5c9-f2d78f04da41
8564 8u https://doi.org/10.1001/jamaoto.2018.3852
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140561307

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