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Search: onr:"swepub:oai:lup.lub.lu.se:0eae8cb9-97e8-4c6c-8e71-0464a32b7d2c" > C-erbB2, p27 and G1...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02749naa a2200361 4500 | |
| 001 | oai:lup.lub.lu.se:0eae8cb9-97e8-4c6c-8e71-0464a32b7d2c | |
| 003 | SwePub | |
| 008 | 160401s2003 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/3058072 URI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Loden, M4 aut |
| 245 | 1 0 | a C-erbB2, p27 and G1/S aberrations in human primary breast cancer |
| 264 | 1 | c 2003 |
| 520 | a Background: C-erbB2 is overexpressed in approximately one-fourth of human breast cancers. In spite of numerous reports suggesting a connection of c-erbB2 overexpression with cell cycle regulation through p27, D cyclins and c-myc. the relationship between c-erbB2 and proliferation through de-regulation of the pRb pathway in primaty breast cancer has not been fully clarified. Materials and Methods: For this purpose we compared the expression of c-erbB2 in a total of 10.5 primary breast tumours with a variety of cell cycle proteins and clinical parameters. Results: GerbB2 was strongly con-elated with down-regulation of p27 and overexpression of c-erbB2 was', as expected, associated with poor survival. However, there was no correlation with proliferation. There was, nevertheless, an association between c-erbB2 and proliferation in certain subtypes of breast cancer, as in oestrogen-receptor-positive e tumours, tumours with high cyclin D1 and in tumours with an overall linear pRb pathway, i.e. tumours with a preserved linearity between cyclin D1, pRb phosphorylation and proliferation. Conclusion: Our results suggest that c-erbB2 may have alternative functions in different subtypes of breast cancer, and further stress that c-erbB2, in addition to promoting proliferation, also functions through other mechanisms in breast cancer. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a proliferation | |
| 653 | a pRb pathway | |
| 653 | a cyclins | |
| 653 | a p27 | |
| 653 | a breast cancer | |
| 653 | a c-erbB2 | |
| 700 | 1 | a Perris, F4 aut |
| 700 | 1 | a Nielsen, NH4 aut |
| 700 | 1 | a Emdin, SO4 aut |
| 700 | 1 | a Landberg, Göranu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)pat-gla |
| 710 | 2 | a Patologi, Malmöb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Anticancer researchg 23:3A, s. 2053-2061q 23:3A<2053-2061x 1791-7530 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/305807 |
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