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Proteoglycans of hy...
Proteoglycans of hyaline cartilage. Electron microscopic studies on isolated molecules
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- Thyberg, J. (författare)
- Karolinska Institutet
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- Lohmander, S. (författare)
- Karolinska Institutet,Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Nedbrytning av ledbrosk: en biologisk process som leder till artros,Forskargrupper vid Lunds universitet,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund OsteoArthritis Division - Molecular marker research group,Lund University Research Groups
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- Heinegard, D. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 1975
- 1975
- Engelska 10 s.
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Ingår i: Biochemical Journal. - 0264-6021. ; 151:1, s. 157-166
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- Proteoglycan monomers from guinea pig costal cartilage, bovine nasal and bovine tracheal cartilage were observed in the electron microscope after being spread in a monomolecular layer with cytochrome c. The proteoglycan molecule appeared as an extended central core filament to which side chain filaments were attached at various intervals. The molecules from the three sources displayed great ultrastructural similarities. On average, the core filament was about 290 nm long, there were about 25 side chain filaments per core filament, the side chain filaments were about 45 nm long, and the distance between the attachment points of the side chain filaments to the core filament was about 11 nm. With regard to overall size of the molecules, no evidence of distinct subpopulations was obtained. Good correlation was found between ultrastructural data for the proteoglycan molecules and chemical data obtained by enzyme digestions and gel chromatography. Together these data strongly support the interpretation of the electron microscopic pictures as indicating a central filament corresponding to the protein core and side chain filaments corresponding to the chondroitin sulphate chain clusters of the proteoglycan monomers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
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- ref (ämneskategori)
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