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Sökning: onr:"swepub:oai:lup.lub.lu.se:110bc747-4c51-4caf-a0f3-8f508253940c" > Cancer Cells Can Ex...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006072naa a2200541 4500
001oai:lup.lub.lu.se:110bc747-4c51-4caf-a0f3-8f508253940c
003SwePub
008210923s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/110bc747-4c51-4caf-a0f3-8f508253940c2 URI
0247 a https://doi.org/10.3389/fonc.2021.6861422 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Adrian, Gabrielu Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Strålterapi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Radiation therapy,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-gra
2451 0a Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic In Vitro-Conditions
264 c 2021-07-29
264 1b Frontiers Media SA,c 2021
520 a Background: Irradiation with ultra-high dose rate (FLASH) has been shown to spare normal tissue without hampering tumor control in several in vivo studies. Few cell lines have been investigated in vitro, and previous results are inconsistent. Assuming that oxygen depletion accounts for the FLASH sparing effect, no sparing should appear for cells irradiated with low doses in normoxia. Methods: Seven cancer cell lines (MDA-MB-231, MCF7, WiDr, LU-HNSCC4, HeLa [early passage and subclone]) and normal lung fibroblasts (MRC-5) were irradiated with doses ranging from 0 to 12 Gy using FLASH (≥800 Gy/s) or conventional dose rates (CONV, 14 Gy/min), with a 10 MeV electron beam from a clinical linear accelerator. Surviving fraction (SF) was determined with clonogenic assays. Three cell lines were further studied for radiation-induced DNA-damage foci using a 53BP1-marker and for cell cycle synchronization after irradiation. Results: A tendency of increased survival following FLASH compared with CONV was suggested for all cell lines, with significant differences for 4/7 cell lines. The magnitude of the FLASH-sparing expressed as a dose-modifying factor at SF=0.1 was around 1.1 for 6/7 cell lines and around 1.3 for the HeLasubclone. Similar cell cycle distributions and 53BP1-foci numbers were found comparing FLASH to CONV. Conclusion: We have found a FLASH effect appearing at low doses under normoxic conditions for several cell lines in vitro. The magnitude of the FLASH effect differed between the cell lines, suggesting inherited biological susceptibilities for FLASH irradiation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
650 7a NATURVETENSKAPx Fysikx Annan fysik0 (SwePub)103992 hsv//swe
650 7a NATURAL SCIENCESx Physical Sciencesx Other Physics Topics0 (SwePub)103992 hsv//eng
653 a cancer cell lines
653 a clonogenic assay
653 a FLASH
653 a normoxia
653 a radiobiology
653 a radioresistance
653 a radiotherapy
653 a ultra-high dose rate irradiation
7001 a Konradsson, Eliseu Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Radiotherapy Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)el0832ko
7001 a Beyer, Sarahu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumörmikromiljön,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)sa8838be
7001 a Wittrup, Andersu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,WCMM- Wallenberg center för molekylär medicinsk forskning,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital4 aut0 (Swepub:lu)medk-awi
7001 a Butterworth, Karl T.u Queen's University Belfast4 aut
7001 a McMahon, Stephen J.u Queen's University Belfast4 aut
7001 a Ghita, Mihaelau Queen's University Belfast4 aut
7001 a Petersson, Kristofferu Skåne University Hospital,University of Oxford4 aut0 (Swepub:lu)kr7445pe
7001 a Ceberg, Cristeru Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Radiotherapy Physics,Forskargrupper vid Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Rausing laboratory of Lund - Tumor section4 aut0 (Swepub:lu)rafy-cce
7102 a LUCC: Lunds universitets cancercentrumb Övriga starka forskningsmiljöer4 org
7730 t Frontiers in Oncologyd : Frontiers Media SAg 11q 11x 2234-943X
8564 u http://dx.doi.org/10.3389/fonc.2021.686142x freey FULLTEXT
8564 u https://www.frontiersin.org/articles/10.3389/fonc.2021.686142/pdf
8564 8u https://lup.lub.lu.se/record/110bc747-4c51-4caf-a0f3-8f508253940c
8564 8u https://doi.org/10.3389/fonc.2021.686142

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