onr:"swepub:oai:lup.lub.lu.se:11271d48-b2fc-4985-a7a8-7dc04b7b3655"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04530naa a2200409 4500 | |
| 001 | oai:lup.lub.lu.se:11271d48-b2fc-4985-a7a8-7dc04b7b3655 | |
| 003 | SwePub | |
| 008 | 191007s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11271d48-b2fc-4985-a7a8-7dc04b7b36552 URI |
| 024 | 7 | a https://doi.org/10.1177/20474873198730622 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Memon, Ashfaque A.u Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-aqm |
| 245 | 1 0 | a Identification of novel diagnostic and prognostic biomarkers for abdominal aortic aneurysm |
| 264 | c 2019-08-29 | |
| 264 | 1 | b Oxford University Press (OUP),c 2020 |
| 300 | a 11 s. | |
| 520 | a Aims: Abdominal aortic aneurysm is a life-threatening condition due to the risk of aneurysm growth and rupture. There are no approved diagnostic or prognostic biomarkers for abdominal aortic aneurysm. We aimed to identify diagnostic and prognostic biomarkers for abdominal aortic aneurysm and to investigate their relationship with abdominal aortic aneurysm diameter and growth. Methods: In this case-control study, patients were included from an abdominal aortic aneurysm screening study on men aged ≥65 years. Of 24,589 examined men, 415 had abdominal aortic aneurysm, out of whom 134 consented to participate in the present study. One hundred and thirty-six screened men with aortic diameter <30 mm, matched for comorbidities and time of sampling were included as non-abdominal aortic aneurysm patients. Ninety-one cardiovascular specific proteins in plasma samples were measured by the Proseek Multiplex CVD III96x96 panel. Results: After Bonferroni correction, plasma levels of 21 proteins associated with proteolysis, oxidative-stress, lipid metabolism, and inflammation were significantly increased, whereas levels of paraoxonase 3, associated with high-density lipoprotein metabolism, were decreased in abdominal aortic aneurysm patients. Combination of growth/differentiation factor 15 and cystatin B had the best ability to discriminate abdominal aortic aneurysm from non-abdominal aortic aneurysm (area under the curve, 0.76; sensitivity, 80% and specificity, 52%). Myeloperoxidase showed the best prognostic value (area under the curve, 0.71; sensitivity, 80% and specificity, 59%) and higher baseline levels of myeloperoxidase were significantly associated with faster abdominal aortic aneurysm growth compared with lower levels, independent of baseline diameter. Conclusions: We have identified multiple proteins associated with abdominal aortic aneurysm diameter and growth with a potential to become novel diagnostic and prognostic biomarkers for abdominal aortic aneurysm. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a Abdominal aortic aneurysm | |
| 653 | a biomarkers | |
| 653 | a diagnosis | |
| 653 | a prognosis | |
| 700 | 1 | a Zarrouk, Moncefu Skåne University Hospital4 aut0 (Swepub:lu)med-mzu |
| 700 | 1 | a Ågren-Witteschus, Sophiau Skåne University Hospital4 aut0 (Swepub:lu)so6457ag |
| 700 | 1 | a Sundquist, Janu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-jsu |
| 700 | 1 | a Gottsäter, Andersu Skåne University Hospital4 aut0 (Swepub:lu)medf-ago |
| 700 | 1 | a Sundquist, Kristinau Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups4 aut0 (Swepub:lu)med-ksq |
| 710 | 2 | a Allmänmedicin och klinisk epidemiologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t European Journal of Preventive Cardiologyd : Oxford University Press (OUP)g 27:2, s. 132-142q 27:2<132-142x 2047-4873x 2047-4881 |
| 856 | 4 | u http://dx.doi.org/10.1177/2047487319873062y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/11271d48-b2fc-4985-a7a8-7dc04b7b3655 |
| 856 | 4 8 | u https://doi.org/10.1177/2047487319873062 |
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