Sökning: onr:"swepub:oai:lup.lub.lu.se:113bb48c-9634-4157-8f7d-d57b8a3b8997" > Impact of progressi...
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000 | 05284naa a2200661 4500 | |
001 | oai:lup.lub.lu.se:113bb48c-9634-4157-8f7d-d57b8a3b8997 | |
003 | SwePub | |
008 | 221010s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:150014361 | |
024 | 7 | a https://lup.lub.lu.se/record/113bb48c-9634-4157-8f7d-d57b8a3b89972 URI |
024 | 7 | a https://doi.org/10.1007/s00380-022-02111-12 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1500143612 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Gasparovic, Hrvoje4 aut |
245 | 1 0 | a Impact of progressive aortic regurgitation on outcomes after left ventricular assist device implantation |
264 | c 2022-06-23 | |
264 | 1 | b Springer Science and Business Media LLC,c 2022 |
520 | a Aortic regurgitation (AR) following continuous flow left ventricular assist device implantation (cf-LVAD) may adversely impact outcomes. We aimed to assess the incidence and impact of progressive AR after cf-LVAD on prognosis, biomarkers, functional capacity and echocardiographic findings. In an analysis of the PCHF-VAD database encompassing 12 European heart failure centers, patients were dichotomized according to the progression of AR following LVAD implantation. Patients with de-novo AR or AR progression (AR_1) were compared to patients without worsening AR (AR_0). Among 396 patients (mean age 53 ± 12 years, 82% male), 153 (39%) experienced progression of AR over a median of 1.4 years on LVAD support. Before LVAD implantation, AR_1 patients were less frequently diabetic, had lower body mass indices and higher baseline NT-proBNP values. Progressive AR did not adversely impact mortality (26% in both groups, HR 0.91 [95% CI 0.61–1.36]; P = 0.65). No intergroup variability was observed in NT-proBNP values and 6-minute walk test results at index hospitalization discharge and at 6-month follow-up. However, AR_1 patients were more likely to remain in NYHA class III and had worse right ventricular function at 6-month follow-up. Lack of aortic valve opening was related to de-novo or worsening AR (P < 0.001), irrespective of systolic blood pressure (P = 0.67). Patients commonly experience de-novo or worsening AR when exposed to continuous flow of contemporary LVADs. While reducing effective forward flow, worsening AR did not influence survival. However, less complete functional recovery and worse RV performance among AR_1 patients were observed. Lack of aortic valve opening was associated with progressive AR. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a Aortic regurgitation | |
653 | a Left ventricular assist device | |
653 | a Outcome | |
700 | 1 | a Jakus, Nina4 aut |
700 | 1 | a Brugts, Jasper J.u Erasmus University Medical Center4 aut |
700 | 1 | a Pouleur, Anne Catherineu Saint-Luc University Hospital,Catholic University of Louvain4 aut |
700 | 1 | a Timmermans, Philippeu University Hospitals Leuven4 aut |
700 | 1 | a Rubiś, Pawelu Jagiellonian University4 aut |
700 | 1 | a Gaizauskas, Edvinasu Vilnius University4 aut |
700 | 1 | a Van Craenenbroeck, Emeline M.u Antwerp University Hospital4 aut |
700 | 1 | a Barge-Caballero, Eduardo4 aut |
700 | 1 | a Grundmann, Sebastian4 aut |
700 | 1 | a Paolillo, Stefaniau University of Naples Federico II4 aut |
700 | 1 | a D’Amario, Domenico4 aut |
700 | 1 | a Braun, Oscaru Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kard-oos |
700 | 1 | a Meyns, Bartu University Hospitals Leuven4 aut |
700 | 1 | a Droogne, Walteru University Hospitals Leuven4 aut |
700 | 1 | a Wierzbicki, Karolu Jagiellonian University4 aut |
700 | 1 | a Holcman, Katarzynau Jagiellonian University4 aut |
700 | 1 | a Planinc, Ivo4 aut |
700 | 1 | a Lovric, Daniel4 aut |
700 | 1 | a Flammer, Andreas J.u University Hospital of Zurich4 aut |
700 | 1 | a Petricevic, Mate4 aut |
700 | 1 | a Biocina, Bojan4 aut |
700 | 1 | a Lund, Lars H.u Karolinska Institutet,Karolinska Institute4 aut |
700 | 1 | a Milicic, Davor4 aut |
700 | 1 | a Ruschitzka, Franku University Hospital of Zurich4 aut |
700 | 1 | a Cikes, Maja4 aut |
710 | 2 | a Erasmus University Medical Centerb Saint-Luc University Hospital4 org |
773 | 0 | t Heart and Vesselsd : Springer Science and Business Media LLCg 37:12, s. 1985-1994q 37:12<1985-1994x 0910-8327x 1615-2573 |
856 | 4 | u http://dx.doi.org/10.1007/s00380-022-02111-1y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/113bb48c-9634-4157-8f7d-d57b8a3b8997 |
856 | 4 8 | u https://doi.org/10.1007/s00380-022-02111-1 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:150014361 |
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