Sökning: onr:"swepub:oai:lup.lub.lu.se:17a9f062-dc3e-4135-95b2-d6f60c1d0114" > Apolipoprotein(a) G...
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000 | 07609naa a2201369 4500 | |
001 | oai:lup.lub.lu.se:17a9f062-dc3e-4135-95b2-d6f60c1d0114 | |
003 | SwePub | |
008 | 160401s2012 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:125097305 | |
024 | 7 | a https://lup.lub.lu.se/record/30558232 URI |
024 | 7 | a https://doi.org/10.1016/j.jacc.2012.01.0782 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1250973052 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Helgadottir, Anna4 aut |
245 | 1 0 | a Apolipoprotein(a) Genetic Sequence Variants Associated With Systemic Atherosclerosis and Coronary Atherosclerotic Burden But Not With Venous Thromboembolism |
264 | 1 | b Elsevier BV,c 2012 |
520 | a Objectives The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. Background It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis. Methods The 2 LPA variants were combined and examined as LPA scores for the association with ischemic stroke (and TOAST [Trial of Org 10172 in Acute Stroke Treatment] subtypes) (effective sample size [n(e)] = 9,396); peripheral arterial disease (n(e) = 5,215); abdominal aortic aneurysm (ne = 4,572); venous thromboembolism (ne = 4,607); intracranial aneurysm (ne = 1,328); CAD (n(e) = 12,716), carotid intima-media thickness (n = 3,714), and angiographic CAD severity (n = 5,588). Results LPA score was associated with ischemic stroke subtype large artery atherosclerosis (odds ratio [OR]: 1.27; p = 6.7 X 10(-4)), peripheral artery disease (OR: 1.47; p = 2.9 x 10(-14)), and abdominal aortic aneurysm (OR: 1.23; p = 6.0 x 10(-5)), but not with the ischemic stroke subtypes cardioembolism (OR: 1.03; p = 0.69) or small vessel disease (OR: 1.06; p = 0.52). Although the LPA variants were not associated with carotid intima-media thickness, they were associated with the number of obstructed coronary vessels (p = 4.8 x 10(-12)). Furthermore, CAD cases carrying LPA risk variants had increased susceptibility to atherosclerotic manifestations outside of the coronary tree (OR: 1.26; p = 0.0010) and had earlier onset of CAD (-1.58 years/allele; p = 8.2 x 10(-8)) than CAD cases not carrying the risk variants. There was no association of LPA score with venous thromboembolism (OR: 0.97; p = 0.63) or intracranial aneurysm (OR: 0.85; p = 0.15). Conclusions LPA sequence variants were associated with atherosclerotic burden, but not with primarily thrombotic phenotypes. (J Am Coll Cardiol 2012; 60: 722-9) (C) 2012 by the American College of Cardiology Foundation | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a association | |
653 | a atherosclerosis | |
653 | a genetic | |
653 | a lipoprotein(a) | |
653 | a thrombosis | |
700 | 1 | a Gretarsdottir, Solveig4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a Holm, Hilma4 aut |
700 | 1 | a Patel, Riyaz S.4 aut |
700 | 1 | a Gudnason, Thorarinn4 aut |
700 | 1 | a Jones, Gregory T.4 aut |
700 | 1 | a van Rij, Andre M.4 aut |
700 | 1 | a Eapen, Danny J.4 aut |
700 | 1 | a Baas, Annette F.4 aut |
700 | 1 | a Tregouet, David-Alexandre4 aut |
700 | 1 | a Morange, Pierre-Emmanuel4 aut |
700 | 1 | a Emmerich, Joseph4 aut |
700 | 1 | a Lindblad, Bengtu Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups4 aut0 (Swepub:lu)kir-bli |
700 | 1 | a Gottsäter, Andersu Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups4 aut0 (Swepub:lu)medf-ago |
700 | 1 | a Kiemeny, Lambertus A.4 aut |
700 | 1 | a Lindholt, Jes S.4 aut |
700 | 1 | a Sakalihasan, Natzi4 aut |
700 | 1 | a Ferrell, Robert E.4 aut |
700 | 1 | a Carey, David J.4 aut |
700 | 1 | a Elmore, James R.4 aut |
700 | 1 | a Tsao, Philip S.4 aut |
700 | 1 | a Grarup, Niels4 aut |
700 | 1 | a Jorgensen, Torben4 aut |
700 | 1 | a Witte, Daniel R.4 aut |
700 | 1 | a Hansen, Torben4 aut |
700 | 1 | a Pedersen, Oluf4 aut |
700 | 1 | a Pola, Roberto4 aut |
700 | 1 | a Gaetani, Eleonora4 aut |
700 | 1 | a Magnadottir, Hulda B.4 aut |
700 | 1 | a Wijmenga, Cisca4 aut |
700 | 1 | a Tromp, Gerard4 aut |
700 | 1 | a Ronkainen, Antti4 aut |
700 | 1 | a Ruigrok, Ynte M.4 aut |
700 | 1 | a Blankensteijn, Jan D.4 aut |
700 | 1 | a Mueller, Thomas4 aut |
700 | 1 | a Wells, Philip S.4 aut |
700 | 1 | a Corral, Javier4 aut |
700 | 1 | a Manuel Soria, Jose4 aut |
700 | 1 | a Carlos Souto, Juan4 aut |
700 | 1 | a Peden, John F.4 aut |
700 | 1 | a Jalilzadeh, Shapour4 aut |
700 | 1 | a Mayosi, Bongani M.4 aut |
700 | 1 | a Keavney, Bernard4 aut |
700 | 1 | a Strawbridge, Rona J.u Karolinska Institutet4 aut |
700 | 1 | a Sabater-Lleal, Mariau Karolinska Institutet4 aut |
700 | 1 | a Gertow, Karlu Karolinska Institutet4 aut |
700 | 1 | a Baldassarre, Damiano4 aut |
700 | 1 | a Nyyssonen, Kristiina4 aut |
700 | 1 | a Rauramaa, Rainer4 aut |
700 | 1 | a Smit, Andries J.4 aut |
700 | 1 | a Mannarino, Elmo4 aut |
700 | 1 | a Giral, Philippe4 aut |
700 | 1 | a Tremoli, Elena4 aut |
700 | 1 | a de Faire, Ulfu Karolinska Institutet4 aut |
700 | 1 | a Humphries, Steve E.4 aut |
700 | 1 | a Hamsten, Andersu Karolinska Institutet4 aut |
700 | 1 | a Haraldsdottir, Vilhelmina4 aut |
700 | 1 | a Olafsson, Isleifur4 aut |
700 | 1 | a Magnusson, Magnus K.u Karolinska Institutet4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Levey, Allan I.4 aut |
700 | 1 | a Markus, Hugh S.4 aut |
700 | 1 | a Kostulas, Konstantinos4 aut |
700 | 1 | a Dichgans, Martin4 aut |
700 | 1 | a Berger, Klaus4 aut |
700 | 1 | a Kuhlenbaeumer, Gregor4 aut |
700 | 1 | a Ringelstein, E. Bernd4 aut |
700 | 1 | a Stoll, Monika4 aut |
700 | 1 | a Seedorf, Udo4 aut |
700 | 1 | a Rothwell, Peter M.4 aut |
700 | 1 | a Powell, Janet T.4 aut |
700 | 1 | a Kuivaniemi, Helena4 aut |
700 | 1 | a Onundarson, Pall T.4 aut |
700 | 1 | a Valdimarsson, Einar4 aut |
700 | 1 | a Matthiasson, Stefan E.4 aut |
700 | 1 | a Gudbjartsson, Daniel F.4 aut |
700 | 1 | a Thorgeirsson, Guomundur4 aut |
700 | 1 | a Quyyumi, Arshed A.4 aut |
700 | 1 | a Watkins, Hugh4 aut |
700 | 1 | a Farrall, Martin4 aut |
700 | 1 | a Thorsteinsdottir, Unnur4 aut |
700 | 1 | a Stefansson, Kari4 aut |
710 | 2 | a Vaskulära sjukdomar - kliniska studierb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Journal of the American College of Cardiologyd : Elsevier BVg 60:8, s. 722-729q 60:8<722-729x 0735-1097x 1558-3597 |
856 | 4 | u http://dx.doi.org/10.1016/j.jacc.2012.01.078y FULLTEXT |
856 | 4 | u https://doi.org/10.1016/j.jacc.2012.01.078 |
856 | 4 8 | u https://lup.lub.lu.se/record/3055823 |
856 | 4 8 | u https://doi.org/10.1016/j.jacc.2012.01.078 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125097305 |
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