Sökning: onr:"swepub:oai:lup.lub.lu.se:2273fe6e-736b-43fe-865b-390c202bf114" > Loci influencing bl...
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000 | 08474naa a2201921 4500 | |
001 | oai:lup.lub.lu.se:2273fe6e-736b-43fe-865b-390c202bf114 | |
003 | SwePub | |
008 | 160401s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/37483242 URI |
024 | 7 | a https://doi.org/10.1093/hmg/dds5552 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Ganesh, Santhi K.4 aut |
245 | 1 0 | a Loci influencing blood pressure identified using a cardiovascular gene-centric array |
264 | c 2013-01-08 | |
264 | 1 | b Oxford University Press (OUP),c 2013 |
520 | a Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped 50 000 single-nucleotide polymorphisms (SNPs) that capture variation in 2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P 2.4 10(6)). We then replicated these associations in an independent set of 65 886 individuals of European ancestry. The findings from expression QTL (eQTL) analysis showed associations of SNPs in the MDM4 region with MDM4 expression. We did not find any evidence of association of the two novel SNPs in MDM4 and HRH1 with sequelae of high BP including coronary artery disease (CAD), left ventricular hypertrophy (LVH) or stroke. In summary, we identified two novel loci associated with BP and confirmed multiple previously reported associations. Our findings extend our understanding of genes involved in BP regulation, some of which may eventually provide new targets for therapeutic intervention. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Tragante, Vinicius4 aut |
700 | 1 | a Guo, Wei4 aut |
700 | 1 | a Guo, Yiran4 aut |
700 | 1 | a Lanktree, Matthew B.4 aut |
700 | 1 | a Smith, Erin N.4 aut |
700 | 1 | a Johnson, Toby4 aut |
700 | 1 | a Castillo, Berta Almoguera4 aut |
700 | 1 | a Barnard, John4 aut |
700 | 1 | a Baumert, Jens4 aut |
700 | 1 | a Chang, Yen-Pei Christy4 aut |
700 | 1 | a Elbers, Clara C.4 aut |
700 | 1 | a Farrall, Martin4 aut |
700 | 1 | a Fischer, Mary E.4 aut |
700 | 1 | a Franceschini, Nora4 aut |
700 | 1 | a Gaunt, Tom R.4 aut |
700 | 1 | a Gho, Johannes M. I. H.4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Gong, Yan4 aut |
700 | 1 | a Isaacs, Aaron4 aut |
700 | 1 | a Kleber, Marcus E.4 aut |
700 | 1 | a Leach, Irene Mateo4 aut |
700 | 1 | a McDonough, Caitrin W.4 aut |
700 | 1 | a Meijs, Matthijs F. L.4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Molony, Cliona M.4 aut |
700 | 1 | a Nolte, Ilja M.4 aut |
700 | 1 | a Padmanabhan, Sandosh4 aut |
700 | 1 | a Price, Tom S.4 aut |
700 | 1 | a Rajagopalan, Ramakrishnan4 aut |
700 | 1 | a Shaffer, Jonathan4 aut |
700 | 1 | a Shah, Sonia4 aut |
700 | 1 | a Shen, Haiqing4 aut |
700 | 1 | a Soranzo, Nicole4 aut |
700 | 1 | a van der Most, Peter J.4 aut |
700 | 1 | a Van Iperen, Erik P. A.4 aut |
700 | 1 | a Van Setten, Jessic A.4 aut |
700 | 1 | a Vonk, Judith M.4 aut |
700 | 1 | a Zhang, Li4 aut |
700 | 1 | a Beitelshees, Amber L.4 aut |
700 | 1 | a Berenson, Gerald S.4 aut |
700 | 1 | a Bhatt, Deepak L.4 aut |
700 | 1 | a Boer, Jolanda M. A.4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Burkley, Ben4 aut |
700 | 1 | a Burt, Amber4 aut |
700 | 1 | a Chakravarti, Aravinda4 aut |
700 | 1 | a Chen, Wei4 aut |
700 | 1 | a Cooper-DeHoff, Rhonda M.4 aut |
700 | 1 | a Curtis, Sean P.4 aut |
700 | 1 | a Dreisbach, Albert4 aut |
700 | 1 | a Duggan, David4 aut |
700 | 1 | a Ehret, Georg B.4 aut |
700 | 1 | a Fabsitz, Richard R.4 aut |
700 | 1 | a Fornage, Myriam4 aut |
700 | 1 | a Fox, Ervin4 aut |
700 | 1 | a Furlong, Clement E.4 aut |
700 | 1 | a Gansevoort, Ron T.4 aut |
700 | 1 | a Hofker, Marten H.4 aut |
700 | 1 | a Hovingh, G. Kees4 aut |
700 | 1 | a Kirkland, Susan A.4 aut |
700 | 1 | a Kottke-Marchant, Kandice4 aut |
700 | 1 | a Kutlar, Abdullah4 aut |
700 | 1 | a LaCroix, Andrea Z.4 aut |
700 | 1 | a Langaee, Taimour Y.4 aut |
700 | 1 | a Li, Yun R.4 aut |
700 | 1 | a Lin, Honghuang4 aut |
700 | 1 | a Liu, Kiang4 aut |
700 | 1 | a Maiwald, Steffi4 aut |
700 | 1 | a Malik, Rainer4 aut |
700 | 1 | a Murugesan, Gurunathan4 aut |
700 | 1 | a Newton-Cheh, Christopher4 aut |
700 | 1 | a OConnell, Jeffery R.4 aut |
700 | 1 | a Onland-Moret, N. Charlotte4 aut |
700 | 1 | a Ouwehand, Willem H.4 aut |
700 | 1 | a Palmas, Walter4 aut |
700 | 1 | a Penninx, Brenda W.4 aut |
700 | 1 | a Pepine, Carl J.4 aut |
700 | 1 | a Pettinger, Mary4 aut |
700 | 1 | a Polak, Joseph F.4 aut |
700 | 1 | a Ramachandran, Vasan S.4 aut |
700 | 1 | a Ranchalis, Jane4 aut |
700 | 1 | a Redline, Susan4 aut |
700 | 1 | a Ridker, Paul M.4 aut |
700 | 1 | a Rose, Lynda M.4 aut |
700 | 1 | a Scharnag, Hubert4 aut |
700 | 1 | a Schork, Nicholas J.4 aut |
700 | 1 | a Shimbo, Daichi4 aut |
700 | 1 | a Shuldiner, Alan R.4 aut |
700 | 1 | a Srinivasan, Sathanur R.4 aut |
700 | 1 | a Stolk, Ronald P.4 aut |
700 | 1 | a Taylor, Herman A.4 aut |
700 | 1 | a Thorand, Barbara4 aut |
700 | 1 | a Trip, Mieke D.4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Verschuren, W. Monique4 aut |
700 | 1 | a Wijmenga, Cisca4 aut |
700 | 1 | a Winkelmann, Bernhard R.4 aut |
700 | 1 | a Wyatt, Sharon4 aut |
700 | 1 | a Young, J. Hunter4 aut |
700 | 1 | a Boehm, Bernhard O.4 aut |
700 | 1 | a Caulfield, Mark J.4 aut |
700 | 1 | a Chasman, Daniel I.4 aut |
700 | 1 | a Davidson, Karina W.4 aut |
700 | 1 | a Doevendans, Pieter A.4 aut |
700 | 1 | a FitzGerald, Garret A.4 aut |
700 | 1 | a Gums, John G.4 aut |
700 | 1 | a Hakonarson, Hakon4 aut |
700 | 1 | a Hillege, Hans L.4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Jarvik, Gail P.4 aut |
700 | 1 | a Johnson, Julie A.4 aut |
700 | 1 | a Kastelein, John J. P.4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Maerz, Winfried4 aut |
700 | 1 | a Mitchell, Braxton D.4 aut |
700 | 1 | a Murray, Sarah S.4 aut |
700 | 1 | a Oldehinkel, Albertine J.4 aut |
700 | 1 | a Rader, Daniel J.4 aut |
700 | 1 | a Reilly, Muredach P.4 aut |
700 | 1 | a Reiner, Alex P.4 aut |
700 | 1 | a Schadt, Eric E.4 aut |
700 | 1 | a Silverstein, Roy L.4 aut |
700 | 1 | a Snieder, Harold4 aut |
700 | 1 | a Stanton, Alice V.4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a van der Schouw, Yvonne T.4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Johnson, Andrew D.4 aut |
700 | 1 | a Munroe, Patricia B.4 aut |
700 | 1 | a de Bakker, Paul I. W.4 aut |
700 | 1 | a Zhu, Xiaofeng4 aut |
700 | 1 | a Levy, Daniel4 aut |
700 | 1 | a Keating, Brendan J.4 aut |
700 | 1 | a Asselbergs, Folkert W.4 aut |
710 | 2 | a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Human Molecular Geneticsd : Oxford University Press (OUP)g 22:8, s. 1663-1678q 22:8<1663-1678x 0964-6906x 1460-2083 |
856 | 4 | u http://dx.doi.org/10.1093/hmg/dds555y FULLTEXT |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/22/8/1663/14140725/dds555.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/3748324 |
856 | 4 8 | u https://doi.org/10.1093/hmg/dds555 |
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