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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03140naa a2200433 4500 | |
| 001 | oai:lup.lub.lu.se:2ebeea3c-32dc-4489-9b93-18a60a6dcd76 | |
| 003 | SwePub | |
| 008 | 160401s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11986842 URI |
| 024 | 7 | a https://doi.org/10.1007/s10753-007-9046-y2 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Lima, Rafael R4 aut |
| 245 | 1 0 | a Diffuse axonal damage, myelin impairment, astrocytosis and inflammatory response following microinjections of NMDA into the rat striatum |
| 264 | c 2007-09-25 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2008 |
| 520 | a White matter damage and inflammatory response are important secondary outcomes after acute neural disorders. Nevertheless, a few studies addressed the temporal outcomes of these pathological events using non-traumatic models of acute brain injury. In the present study, we describe acute inflammatory response and white matter neuropathology between 1 and 7 days after acute excitotoxic striatal damage. Twenty micrometer sections were stained by hematoxylin and eosin technique for gross histopathological analysis and immunolabed for neutrophils (anti-mbs-1), activated macrophages/microglia (anti-ed1), astrocytes (anti-gfap), damaged axons (anti-beta app) and myelin basic protein (MBP). Recruitment peak of neutrophils and macrophages occurred at 1 and 7 days post-nmda injection, respectively. Diffuse damaged axons (beta-app + end-bulbs) were apparent at 7 days, concomitant with progressive myelin impairment and astrocytosis. Further studies using electron microscopy and blockers of inflammatory response and glutamatergic receptors should be performed to confirm and address the mechanisms of white matter damage following an excitotoxic lesion. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a neutrophils | |
| 653 | a macrophages | |
| 653 | a excitotoxicity | |
| 653 | a white matter damage | |
| 653 | a basal ganglia | |
| 700 | 1 | a Guimaraes-Silva, Joanilson4 aut |
| 700 | 1 | a Oliveira, Jorge L4 aut |
| 700 | 1 | a Costa, Ana Maria R4 aut |
| 700 | 1 | a Souza-Rodrigues, Renata D4 aut |
| 700 | 1 | a Dos Santos, Claudia D4 aut |
| 700 | 1 | a Picanco-Diniz, Cristovam W4 aut |
| 700 | 1 | a Gomes-Leal, Wallaceu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-wg_ |
| 710 | 2 | a Neurologi, Lundb Sektion IV4 org |
| 773 | 0 | t Inflammationd : Springer Science and Business Media LLCg 31:1, s. 24-35q 31:1<24-35x 0360-3997x 1573-2576 |
| 856 | 4 | u http://dx.doi.org/10.1007/s10753-007-9046-yy FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1198684 |
| 856 | 4 8 | u https://doi.org/10.1007/s10753-007-9046-y |
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