onr:"swepub:oai:lup.lub.lu.se:359471b0-6afa-428b-b61e-b387d146b9e5"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03599naa a2200577 4500 | |
| 001 | oai:lup.lub.lu.se:359471b0-6afa-428b-b61e-b387d146b9e5 | |
| 003 | SwePub | |
| 008 | 190903s1998 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/359471b0-6afa-428b-b61e-b387d146b9e52 URI |
| 024 | 7 | a https://doi.org/10.1016/s0167-0115(98)00049-42 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Sharma, Pu Uppsala University4 aut |
| 245 | 1 0 | a Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor |
| 264 | 1 | b Elsevier BV,c 1998 |
| 520 | a Five neuropeptide Y (NPY) receptor subtypes have been cloned in mammals. The degree of sequence conservation differs considerably between subtypes as well as between evolutionary lineages. To shed further light on this, we have cloned the five NPY receptors in the guinea pig. Here, we report the cloning of the guinea pig Y2 receptor. The Y2 receptor is generally highly conserved, with 90-95% identity between different orders of mammals, including the guinea pig. The guinea pig receptor has a divergent cytoplasmic tail, indicating possible differences in regulation of signalling and/or down regulation. COS-7 cells transiently transfected with the gpY2 receptor show saturable 125I-PYY binding with a Kd = 6 pM. In displacement experiments, the gpY2 receptor was similar to the human and rat receptors with the following rank order of potencies: pNPY > pPYY > pNPY13-36 = pNPY22-36 > [Leu31Pro34]NPY > BIBP3226. Thus, the guinea pig Y2 receptor is well conserved in comparison with human and rat with regard to both amino acid sequence and pharmacological profile. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
| 653 | a Amino Acid Sequence | |
| 653 | a Animals | |
| 653 | a Arginine/analogs & derivatives | |
| 653 | a COS Cells | |
| 653 | a Cloning, Molecular | |
| 653 | a Conserved Sequence | |
| 653 | a Gene Expression | |
| 653 | a Guinea Pigs | |
| 653 | a Humans | |
| 653 | a In Vitro Techniques | |
| 653 | a Kinetics | |
| 653 | a Molecular Sequence Data | |
| 653 | a Neuropeptide Y/analogs & derivatives | |
| 653 | a Peptide Fragments/metabolism | |
| 653 | a Peptide YY/metabolism | |
| 653 | a Rats | |
| 653 | a Receptors, Neuropeptide Y/chemistry | |
| 653 | a Recombinant Proteins/chemistry | |
| 653 | a Sequence Homology, Amino Acid | |
| 653 | a Transfection | |
| 700 | 1 | a Holmberg, S Ku Uppsala University4 aut |
| 700 | 1 | a Eriksson, Hu Uppsala University4 aut |
| 700 | 1 | a Beck-Sickinger, A Gu ETH Zürich4 aut |
| 700 | 1 | a Grundemar, Lu Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-lgd |
| 700 | 1 | a Larhammar, Du Uppsala University4 aut |
| 710 | 2 | a Uppsala Universityb ETH Zürich4 org |
| 773 | 0 | t Regulatory Peptidesd : Elsevier BVg 75-76, s. 23-28q 75-76<23-28x 0167-0115 |
| 856 | 4 | u http://dx.doi.org/10.1016/s0167-0115(98)00049-4y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/359471b0-6afa-428b-b61e-b387d146b9e5 |
| 856 | 4 8 | u https://doi.org/10.1016/s0167-0115(98)00049-4 |
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